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B cell-directed therapies in type 1 diabetes

Abstract

B cells play a pathogenic role as antigen-presenting cells and autoantibody secretors in the lead up to T cell-mediated autoimmune destruction of insulin-producing beta cells in type 1 diabetes (T1D). This has led to significant interest in the use of B cell depletion therapies as a treatment for T1D. In this review, we compare results from five recent studies that used distinct B cell-depleting agents and protocols to successfully prevent and even reverse T1D in the non-obese diabetic (NOD) mouse model. We discuss how information gained from animal studies could be used to improve on the positive outcomes of a completed phase II clinical trial of the B cell-depleting drug rituximab in humans with recent-onset T1D.

ISBN 1471-4906 (Linking)
Authors Marino, E.; Silveira, P.A.; Stolp, J.; Grey, S. T.:
Garvan Authors Dr Jessica Stolp , A/Prof Shane Grey
Publisher Name TRENDS IMMUNOL
Published Date 2011-06-03 00:00:00
Published Volume 32
Published Issue 6
Published Pages 287-94
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21531625
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?11000_11443/Marino et al. TII 2011.pdf