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Hypercalcaemia as a prodromal feature of indolent Pneumocystis jivorecii after renal transplantation

Abstract

Following renal transplantation, hypercalcaemia is frequently caused by persisting hyperparathyroidism. Unregulated extrarenal 1,25-dihydroxyvitamin D (1,25(OH)(2)D) synthesis, which is well recognized as a cause of hypercalcaemia in granulomatous diseases, may also occur after kidney transplantation. This mechanism is also likely to be responsible for hypercalcaemia reported during treatment of cytomegalovirus and associated with acute symptomatic pneumocystis jivorecii pneumonia (PCP). Hypercalcaemia as a prodromal feature of indolent PCP has not been described. We report a renal transplant recipient who developed hypercalcaemia 30 months post-transplant due to extrarenal production of 1,25(OH)(2)D. Two months later, PCP was diagnosed and hypercalcaemia resolved after initiation of treatment.

Type Journal
ISBN 1460-2385 (Electronic) 0931-0509 (Linking)
Authors Bency, R.; Roger, S. D.; Elder, G. J.;
Garvan Authors A/Prof Grahame Elder
Publisher Name NEPHROL DIAL TRANSPL
Published Date 2011-01-01 00:00:00
Published Volume 26
Published Issue 5
Published Pages 1740-2
URL http://www.ncbi.nlm.nih.gov/pubmed/21378150
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?11012_11400/11 Bency Nephrol DT_.pdf