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Synthesis and in vitro evaluation of analogues of avocado-produced toxin (+)-(R)-persin in human breast cancer cells

Abstract

A structure-activity study of several new synthetic analogues of the avocado-produced toxin persin has been conducted, with compounds being evaluated for their cytostatic and pro-apoptotic effects in human breast cancer cells. A 4-pyridinyl derivative demonstrated activity comparable to that of the natural product, suggesting future directions for exploration of structure-activity relationships.

Type Journal
Authors Brooke, D.G.; Shelley, E.J.; Roberts, C.G.; Denny, W.A.; Sutherland, R.L.; Butt, A.J.
Publisher Name BIOORGAN MED CHEM
Published Date 2011-11-03 00:00:00
Published Volume 19
Published Issue 23
Published Pages 7033-43
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22044656
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?11118_11681/11 Brooke BMC_.pdf