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Regional activation of the cancer genome by long-range epigenetic remodeling

Abstract

Epigenetic gene deregulation in cancer commonly occurs through chromatin repression and promoter hypermethylation of tumor-associated genes. However, the mechanism underpinning epigenetic-based gene activation in carcinogenesis is still poorly understood. Here, we identify a mechanism of domain gene deregulation through coordinated long-range epigenetic activation (LREA) of regions that typically span 1 Mb and harbor key oncogenes, microRNAs, and cancer biomarker genes. Gene promoters within LREA domains are characterized by a gain of active chromatin marks and a loss of repressive marks. Notably, although promoter hypomethylation is uncommon, we show that extensive DNA hypermethylation of CpG islands or "CpG-island borders" is strongly related to cancer-specific gene activation or differential promoter usage. These findings have wide ramifications for cancer diagnosis, progression, and epigenetic-based gene therapies.

Type Journal
Authors Bert, S.A.; Robinson, M.D.; Strbenac, D.; Statham, A.L.; Song, J.Z.; Hulf, T.; Sutherland, R.L.; Coolen, M.W.; Stirzaker, C.; Clark, S.J.
Garvan Authors Aaron Statham , Dr Clare Stirzaker , Dr Jenny Song , Saul Bert , Prof Susan Clark
Publisher Name CANCER CELL
Published Date 2013-01-01 00:00:00
Published Volume 23
Published Issue 1
Published Pages 9-22
URL http://www.ncbi.nlm.nih.gov/pubmed/23245995
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?11174_12199/13_Bert_CancerCell_.pdf