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Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal and obesogenic diets

Abstract

Food intake and body weight are controlled by a variety of central and peripheral factors, but the exact mechanisms behind these processes are still not fully understood. Here we show that that macrophage inhibitory cytokine-1 (MIC-1/GDF15), known to have anorexigenic effects particularly in cancer, provides protection against the development of obesity. Both under a normal chow diet and an obesogenic diet, the transgenic overexpression of MIC-1/GDF15 in mice leads to decreased body weight and fat mass. This lean phenotype was associated with decreased spontaneous but not fasting-induced food intake, on a background of unaltered energy expenditure and reduced physical activity. Importantly, the overexpression of MIC-1/GDF15 improved glucose tolerance, both under normal and high fat-fed conditions. Altogether, this work shows that the molecule MIC-1/GDF15 might be beneficial for the treatment of obesity as well as perturbations in glucose homeostasis.

Type Journal
Authors Macia, L.; Tsai, V, W-W.; Nguyen, A.D.; Johnen, H.; Kuffner, T.; Shi, Y-C.; Lin, S.; Herzog, H.; Brown, D.A.; Breit, S.N.; Sainsbury, A.
Publisher Name PLoS ONE
Published Date 2012-04-20 00:00:00
Published Volume 7
Published Issue 4
Published Pages e34868
URL http://www.ncbi.nlm.nih.gov/pubmed/22514681
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?11375_11819/PONE-D-11-25693.pdf