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Novel links between HIFs, type 2 diabetes, and metabolic syndrome

Abstract

Hypoxia inducible factors (HIFs) are master-regulators of cellular responses to hypoxia, and thus are crucial for survival. HIFs also play a role in regulating cellular processes in beta-cells, liver, muscle, and adipose tissue, have effects on the regulation of weight, and play a role in type 2 diabetes (T2D). Indeed, in people with T2D the HIF pathway is dyregulated in major metabolic tissues involved in the pathogenesis of diabetes. This review covers the contrasting, complementary and conflicting effects of decreasing and increasing HIFs in various tissues, and shows that a delicate balance exists between HIF levels and optimal metabolic function. We propose that increasing the activity of HIFs might be a potential therapeutic strategy for treating T2D.

Type Journal
Authors Girgis, C. M.; Cheng, K.; Scott, C. H.; Gunton, J. E.
Garvan Authors Christian Girgis , Prof Jenny Gunton
Publisher Name TRENDS ENDOCRINOL MET
Published Date 2012-07-07 00:00:00
Published Volume 23
Published Issue 8
Published Pages 372-80
URL http://www.ncbi.nlm.nih.gov/pubmed/22766319
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?11402_12028/12 Girgis Trends Endo Met_.pdf