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Diimidazo[1,2-c:4',5'-e]pyrimidines: adenosine agonist activity demonstrated by microphysiometry

Abstract

Silicon-based microphysiometry, measuring extracellular acidification rate of cells in culture, demonstrated that a series of diimidazo[1,2-c:4',5'-e]pyrimidines were agonists at the human adenosine A1 receptor. 5-amino-7,8-dihydro-3-ribofuranose-8-(R)-(phenyl)-3H-diimidazo [1,2-c:4',5'-e]pyrimidine (2a) had an EC50 of 100 microM and reached 90% of the Emax produced by R-PIA.

Type Journal
ISBN 0960-894X (Print)
Authors Camp, D.;Green, J. M.;Kaiser, S. M.;Moni, R. W.;Townsend-Nicholson, A.;Schofield, P. R.;Quinn, R. J. :
Publisher Name BIOORG MED CHEM LETT
Published Date 1998-01-01 00:00:00
Published Volume 8
Published Issue 6
Published Pages 691-4
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9871584
Status Published In-print