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Mouse models of inflammatory bowel disease - insights into the mechanisms of inflammation-associated colorectal cancer.

Abstract

The association between chronic inflammation and cancer has been noted for at least a century but the exact molecular mechanisms of cancer initiation and promotion by such inflammation are still poorly understood. The gastrointestinal tract is a unique organ where maintaining a balance between the colonic epithelial cells, the immune system and a fine-tuned response to the resident microflora is crucial for preserving the gut homeostasis. A breakdown of the tight interdependent regulation of the epithelium?immunity?microbiota triangle leads to inflammatory bowel disorders and may promote cancer. This review focuses on inflammation-associated colorectal cancer in mouse models of the disease and highlights emerging research trends.

Type Journal
Authors Mladenova, D.; Kohonen-Corish, M.R.J.
Garvan Authors Dr Dessislava Mladenova , A/Prof Maija Kohonen-Corish
Publisher Name IN VIVO
Published Date 2012-07-10 00:00:00
Published Volume 26
Published Issue 4
Published Pages 627-46
URL http://www.ncbi.nlm.nih.gov/pubmed/22773577
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?11470_11934/12_Mladenova_InVivo copy.pdf