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Long Noncoding RNAs in Cardiac Development and Pathophysiology

Abstract

Heart function requires sophisticated regulatory networks to orchestrate organ development, physiological responses, and environmental adaptation. Until recently, it was thought that these regulatory networks are composed solely of protein-mediated transcriptional control and signaling systems; consequently, it was thought that cardiac disease involves perturbation of these systems. However, it is becoming evident that RNA, long considered to function primarily as the platform for protein production, may in fact play a major role in most, if not all, aspects of gene regulation, especially the epigenetic processes that underpin organogenesis. These include not only well-validated classes of regulatory RNAs, such as microRNAs, but also tens of thousands of long noncoding RNAs that are differentially expressed across the entire genome of humans and other animals. Here, we review this emerging landscape, summarizing what is known about their functions and their role in cardiac biology, and provide a toolkit to assist in exploring this previously hidden layer of gene regulation that may underpin heart adaptation and complex heart diseases. Circ Res. 2012 Oct 26;111(10):1349-62. doi: 10.1161/CIRCRESAHA.112.268953.

Type Journal
ISBN 1524-4571 (Electronic) 0009-7330 (Linking)
Authors Schonrock, N.; Harvey, R. P.; Mattick, J. S.;
Garvan Authors Prof John Mattick
Publisher Name CIRC RES
Published Date 2012-01-01 00:00:00
Published Volume 111
Published Issue 10
Published Pages 1349-62
URL http://www.ncbi.nlm.nih.gov/pubmed/23104877
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?11610_12078/12_Schonrock_CircRes.pdf