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Three-dimensional cancer models mimic cell-matrix interactions in the tumour microenvironment

Abstract

Basic in vitro systems can be used to model and assess complex diseases, such as cancer. Recent advances in this field include the incorporation of multiple cell types and extracellular matrix proteins into three-dimensional (3D) models to recapitulate the structure, organization and functionality of live tissue in situ. Cells within such a 3D environment behave very differently from cells on two-dimensional (2D) substrates, as cell-matrix interactions trigger signalling pathways and cellular responses in 3D, which may not be observed in 2D. Thus, the use of 3D systems can be advantageous for the assessment of disease progression over 2D set-ups alone. Here, we highlight the current advantages and challenges of employing 3D systems in the study of cancer and provide an overview to guide the appropriate use of distinct models in cancer research.

Type Journal
ISBN 1460-2180 (Electronic) 0143-3334 (Linking)
Authors Herrmann, D.; Conway, J. R.; Vennin, C.; Magenau, A.; Hughes, W. E.; Morton, J. P.; Timpson, P.;
Garvan Authors Dr Astrid Magenau , Claire Vennin , Dr David Herrmann , James Conway , Dr Paul Timpson , Dr William Hughes
Publisher Name CARCINOGENESIS
Published Date 2014-06-01 00:00:00
Published Volume 35
Published Issue 8
Published Pages 1671-1679
URL http://www.ncbi.nlm.nih.gov/pubmed/24903340
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?12255_12639/14_Hermann_Carcinogen_.pdf