Publications

Publication Search

Search for publications by

Lipotoxic endoplasmic reticulum stress, beta cell failure, and type 2 diabetes mellitus

Abstract

Failure of the unfolded protein response (UPR) to maintain optimal folding of pro-insulin in the endoplasmic reticulum (ER) leads to unresolved ER stress and beta cell death. This contributes not only to some rare forms of diabetes, but also to type 2 diabetes mellitus (T2DM). Many key findings, elaborated over the past decade, are based on the lipotoxicity model, entailing chronic exposure of beta cells to elevated levels of fatty acids (FAs). Here, we update recent progress on how FAs initiate ER stress, particularly via disruption of protein trafficking, and how this leads to apoptosis. We also highlight differences in how beta cells are impacted by the classic UPR, versus the more selective UPR that arises as part of a broader response to lipotoxicity.

Type Journal
ISBN 1879-3061 (Electronic) 1043-2760 (Linking)
Authors Biden, T. J.; Boslem, E.; Chu, K. Y.; Sue, N.;
Garvan Authors Dr Kwan Yi Chu , Dr Nancy Sue , Prof Trevor Biden
Publisher Name TRENDS ENDOCRINOL MET
Published Date 2014-01-01 00:00:00
Published Volume 25
Published Issue 8
Published Pages 389-98
URL http://www.ncbi.nlm.nih.gov/pubmed/24656915
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?12310_12894/14_Biden_TEM_.pdf