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COMPARTMENTS: unification and visualization of protein subcellular localization evidence

Abstract

Information on protein subcellular localization is important to understand the cellular functions of proteins. Currently, such information is manually curated from the literature, obtained from high-throughput microscopy-based screens and predicted from primary sequence. To get a comprehensive view of the localization of a protein, it is thus necessary to consult multiple databases and prediction tools. To address this, we present the COMPARTMENTS resource, which integrates all sources listed above as well as the results of automatic text mining. The resource is automatically kept up to date with source databases, and all localization evidence is mapped onto common protein identifiers and Gene Ontology terms. We further assign confidence scores to the localization evidence to facilitate comparison of different types and sources of evidence. To further improve the comparability, we assign confidence scores based on the type and source of the localization evidence. Finally, we visualize the unified localization evidence for a protein on a schematic cell to provide a simple overview. Database URL: http://compartments.jensenlab.org.

Type Journal
ISBN 1758-0463 (Electronic)
Authors Binder, J. X.; Pletscher-Frankild, S.; Tsafou, K.; Stolte, C.; O'Donoghue, S. I.; Schneider, R.; Jensen, L. J.;
Garvan Authors
Publisher Name Database: The Journal of Biological Databases and Curation
Published Date 2014-01-01 00:00:00
Published Volume 2014
Published Pages bau012
URL http://www.ncbi.nlm.nih.gov/pubmed/24573882
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?12312_12895/14_Binder_Database_.pdf