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The rise of regulatory RNA

Abstract

Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence suggests that RNA is not only functional as a messenger between DNA and protein but also involved in the regulation of genome organization and gene expression, which is increasingly elaborate in complex organisms. Regulatory RNA seems to operate at many levels; in particular, it plays an important part in the epigenetic processes that control differentiation and development. These discoveries suggest a central role for RNA in human evolution and ontogeny. Here, we review the emergence of the previously unsuspected world of regulatory RNA from a historical perspective.

Type Journal
ISBN 1471-0064 (Electronic) 1471-0056 (Linking)
Authors Morris, K. V.; Mattick, J. S.;
Garvan Authors Prof John Mattick
Publisher Name NAT REV GENET
Published Date 2014-01-01 00:00:00
Published Volume 15
Published Issue 6
Published Pages 423-37
URL http://www.ncbi.nlm.nih.gov/pubmed/24776770
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?12400_12765/nrg3722.pdf