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Prostate cancer epigenetic biomarkers: next-generation technologies

Abstract

Cancer is caused by a combination of genetic alterations and gross changes to the epigenetic landscape that together result in aberrant cancer gene regulation. Therefore, we need to fully sequence both the cancer genome and the matching cancer epigenomes before we can fully integrate the suite of molecular mechanisms involved in initiation and progression of cancer. A further understanding of epigenetic aberrations has a great potential in the next era of molecular genomic pathology in cancer detection and treatment in all types of cancer, including prostate cancer. In this review, we discuss the most common epigenetic aberrations identified in prostate cancer with the biomarker potential. We also describe the innovative and current epigenomic technologies used for the identification of epigenetic-associated changes in prostate cancer and future translational applications in molecular pathology for cancer detection and prognosis.Oncogene advance online publication, 19 May 2014; doi:10.1038/onc.2014.111.

Type Journal
ISBN 1476-5594 (Electronic) 0950-9232 (Linking)
Authors Valdes-Mora, F.; Clark, S. J.;
Garvan Authors Dr Fatima Valdes Mora , Prof Susan Clark
Publisher Name ONCOGENE
Published Date 2015-01-01 00:00:00
Published Volume 34
Published Issue 13
Published Pages 1609-1618
URL http://www.ncbi.nlm.nih.gov/pubmed/24837368
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?12470_12801/onc2014111a.pdf