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Emerging drug target in pancreatic cancer: placing Sirtuin 1 on the sanvas

Abstract

Sirtuin 1 is a protein deacetylase that regulates a large number of proteins often functionally implicated in tumor development and progression. Its pleiotropic function has turned SIRT1 into an attractive chemotherapeutic target, underscored by very promising preclinical results with SIRT1 inhibitors in the treatment of chronic myeloid leukemia. Here, we revisit the studies on SIRT1 as an emerging target for therapy in pancreatic cancer, a tumor with dismal outcomes for which currently few therapeutic options are available. We highlight those potential SIRT1 target genes that are commonly affected in pancreatic cancer according to recent genomic analyses.

Type Journal
Authors Giry-Laterriere, M.; Pinho, A. V.; Eling, N.; Chantrill, L.; Rooman, I.
Garvan Authors Dr Andreia Pinho , Dr Lorraine Chantrill
Publisher Name CURR CANCER DRUG TAR
Published Date 2015-01-01 00:00:00
Published Volume 15
Published Issue 6
Published Pages 463-468
URL http://www.ncbi.nlm.nih.gov/pubmed/26282546
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?12905_13434/15_Giry-Laterriere_CCDT.pdf