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BAFF AND APRIL: a tutorial on B cell survival

Abstract

BAFF, a member of the TNF family, is a fundamental survival factor for transitional and mature B cells. BAFF overexpression leads to an expanded B cell compartment and autoimmunity in mice, and elevated amounts of BAFF can be found in the serum of autoimmune patients. APRIL is a related factor that shares receptors with BAFF yet appears to play a different biological role. The BAFF system provides not only potential insight into the development of autoreactive B cells but a relatively simple paradigm to begin considering the balancing act between survival, growth, and death that affects all cells.

Type Journal
ISBN 0732-0582 (Print)
Authors Mackay, F.;Schneider, P.;Rennert, P.;Browning, J. :
Publisher Name ANNU REV IMMUNOL
Published Date 2003-01-01 00:00:00
Published Volume 21
Published Pages 231-64
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12427767
Status Published In-print