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Grb7-based molecular therapeutics in cancer

Abstract

Traditional anti-cancer drugs preferentially kill rapidly growing tumour cells rather than normal cells. However, most of these drugs have no preferential selection towards cancer cells and are taken up by the whole body, resulting in significant adverse side effects. Therapeutic molecules that could specifically inhibit undesirable phenotypes are an attractive way of eliminating cancer cells. There is a widespread effort to develop inhibitors against signal transduction molecules that play a key role in the proliferative, migratory and invasive properties of a cancer cell. Grb7 is an adaptor-type signalling protein that is recruited via its Src-homology 2 (SH2) domain to a variety of tyrosine kinases. Grb7 is overexpressed in breast, oesophageal and gastric cancers, and may contribute to the invasive potential of cancer cells. Molecular interactions involving Grb7 therefore provide attractive targets for therapeutic intervention.

Type Journal
ISBN 1462-3994 (Electronic)
Authors Pero, S. C.;Daly, R. J.;Krag, D. N. :
Publisher Name EXPERT REVIEWS IN MOLECULAR MEDICINE
Published Date 2003-01-01 00:00:00
Published Volume 5
Published Issue 14
Published Pages 1-11
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14585167
Status Published In-print