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The genetics and pathophysiology of diabetes mellitus type II

Abstract

Type II diabetes is a common, complex and heterogeneous group of disorders of growing public health concern. Paradoxically, rare monogenic forms of diabetes mellitus have been the most informative regarding diabetes pathophysiology to date. We discuss disappointing results of genetic approaches thus far, emphasizing the genetic heterogeneity underlying the common phenotypic endpoint of elevated blood glucose level and the phenotypic misclassification in large studies resulting from this admixture and from the obligatory use of epidemiological or clinical surrogate measures. We suggest that novel approaches that take explicit account of the phenotypic, environmental and genetic complexities of type II diabetes are needed and discuss some principles that might underlie such approaches.

Type Journal
ISBN 0141-8955 (Print)
Authors Jenkins, A. B.;Campbell, L. V. :
Publisher Name J INHERIT METAB DIS
Published Date 2004-01-01 00:00:00
Published Volume 27
Published Issue 3
Published Pages 331-47
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15190192
Status Published In-print