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Wnt signalling via the epidermal growth factor receptor: a role in breast cancer?

Abstract

Recent data have suggested the epidermal-growth-factor receptor (EGFR) as a point of convergence for several different classes of receptor. Civenni and colleagues have now demonstrated crosstalk between Wnt signalling and the EGFR, showing that in breast epithelial cells Wnts activate downstream targets of the EGFR, including cyclin D1. Given the role of members of these pathways in the aetiology of breast cancer and as markers of outcome and potential therapeutic targets in breast cancer, this observation has a number of potential implications important for both the basic biology of breast cancer and the clinical management of the disease.

Type Journal
ISBN 1465-542X (Electronic)
Authors Musgrove, E. A. :
Publisher Name BREAST CANCER RES
Published Date 2004-01-01 00:00:00
Published Volume 6
Published Issue 2
Published Pages 65-8
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14979908
Status Published In-print