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Follicular B helper T cells in antibody responses and autoimmunity

Abstract

T-cell help for B cells is essential for high-affinity antibody responses and B-cell memory. Recently, the identity of a discrete follicular population of T cells that has a crucial role in this process has become clearer. Similar to primed CD4(+) T cells in the tonsils and memory CD4(+) T cells in the peripheral blood, this follicular population of T cells expresses CXC-chemokine receptor 5 (CXCR5). Owing to their distinct homing preferences and helper function, these T cells differ from T helper 1 and T helper 2 cells and have been denoted follicular B helper T cells. Here, we outline the central role of this subset in normal and pathological immune responses.

Type Journal
ISBN 1474-1733 (Print)
Authors Vinuesa, C. G.;Tangye, S. G.;Moser, B.;Mackay, C. R. :
Publisher Name NAT REV IMMUNOL
Published Date 2005-01-01 00:00:00
Published Volume 5
Published Issue 11
Published Pages 853-65
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16261173
Status Published In-print