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A major histocompatibility complex class I-dependent subset of memory phenotype CD8+ cells

Abstract

Most memory phenotype (MP) CD44(hi) CD8(+) cells are resting interleukin (IL)-15-dependent cells characterized by high expression of the IL-2/IL-15 receptor beta (CD122). However, some MP CD8(+) cells have a CD122(lo) phenotype and are IL-15 independent. Here, evidence is presented that the CD122(lo) subset of MP CD8(+) cells is controlled largely by major histocompatibility complex (MHC) class I molecules. Many of these cells display surface markers typical of recently activated T cells (CD62L(lo), CD69(hi), CD43(hi), and CD127(lo)) and show a high rate of background proliferation. Cells with this phenotype are highly enriched in common gamma chain-deficient mice and absent from MHC-I(-/-) mice. Unlike CD122(hi) CD8(+) cells, CD122(lo) MP CD8(+) cells survive poorly after transfer to MHC-I(-/-) hosts and cease to proliferate. Although distinctly different from typical antigen-specific memory cells, CD122(lo) MP CD8(+) cells closely resemble the antigen-dependent memory CD8(+) cells found in chronic viral infections.

Type Journal
ISBN 0022-1007 (Print)
Authors Boyman, O.;Cho, J. H.;Tan, J. T.;Surh, C. D.;Sprent, J. :
Garvan Authors Prof Jonathan Sprent
Publisher Name J EXP MED
Published Date 2006-01-01 00:00:00
Published Volume 203
Published Issue 7
Published Pages 1817-25
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16818671
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?2020_10541/06 Boyman JEM 1817.pdf