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Development of a closed-loop artificial pancreas

Abstract

A closed-loop glucose controlled insulin infusion system was developed, consisting of elements for continuous blood glucose analysis, a computer control system, and infusion systems. Improvements include decreased size, cost reduction and better performance. The algorithm used was a piecewise linear representation of the sigmoidal curve commonly employed. The apparatus has been applied to simulation of the healthy beta cell and glucose clamp studies.

Type Journal
ISBN 0170-5903 (Print)
Authors Kraegen, E. W.;Whiteside, R.;Bell, D.;Chia, Y. O.;Lazarus, L. :
Garvan Authors Prof Ted Kraegen
Publisher Name Horm Metab Res Suppl
Published Date 1979-01-01 00:00:00
Published Issue 8
Published Pages 38-42
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=395087
Status Published In-print