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Regulation of naive T cell function by the NF-kappaB2 pathway

Abstract

T cell activation involves the orchestration of several signaling pathways, including that of the 'classical' transcription factor NF-kappaB components NF-kappaB1-RelA. The function of the 'nonclassical' NF-kappaB2-RelB pathway is less clear, although T cells lacking components of this pathway have activation defects. Here we show that mice deficient in NF-kappaB-inducing kinase have a complex phenotype consisting of immunosuppression mediated by CD25(-)Foxp3(-) memory CD4(+) cells and, in the absence of those cells, hyper-responsive naive CD4(+) T cells, which caused autoimmune lesions after adoptive transfer into hosts deficient in recombination-activating genes. Biochemical studies indicated involvement of a cell-intrinsic mechanism in which NF-kappaB2 (p100) limits nuclear translocation of NF-kappaB1-RelA and thereby functions as a regulatory 'brake' for the activation of naive T cells.

Type Journal
ISBN 1529-2908 (Print)
Authors Ishimaru, N.;Kishimoto, H.;Hayashi, Y.;Sprent, J. :
Garvan Authors Prof Jonathan Sprent
Publisher Name NAT IMMUNOL
Published Date 2006-01-01 00:00:00
Published Volume 7
Published Issue 7
Published Pages 763-72
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16732290
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?2067_10573/06 Ishimaru Nat Imm 763.pdf