The role of the BAFF/APRIL system on T cell function
BAFF is a key factor controlling B cell survival and maturation and its over-expression promotes B cell-mediated autoimmune disorders and participates in the progression of B cell lymphomas. Yet, BAFF and a related ligand APRIL are expressed by T lymphocytes and modulate their functions. BAFF and APRIL promote T cell activation and survival. BAFF over-expression in transgenic (Tg) mice enhances T helper 1 (Thl)-driven delayed-type hypersensitivity (DTH), but inhibits T helper 2 (Th2) cell-mediated allergic airway inflammation in mice. Some of these effects are also dependent on BAFF-induced modification of the B cell compartment. Therefore, direct BAFF/APRIL signalling in T cells and/or T cell modulation in response to a BAFF-modified B cell compartment may play an important role in inflammation and immunomodulation.
|Authors||Mackay, F.;Leung, H. :|
|Publisher Name||SEMIN IMMUNOL|
|Published Date||2006-01-01 00:00:00|
|OpenAccess Link||https://publications.gimr.garvan.org.au/download.php?2088_10584/06 MackayF SemImm.pdf|