Publications

Publication Search

Search for publications by

Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}

Abstract

IL-15 is normally presented in vivo as a cell-associated cytokine bound to IL-15Ralpha. We show here that the biological activity of soluble IL-15 is much improved after interaction with recombinant soluble IL-15Ralpha; after injection, soluble IL-15/IL-15Ralpha complexes rapidly induce strong and selective expansion of memory-phenotype CD8(+) cells and natural killer cells. These findings imply that binding of IL-15Ralpha to IL-15 may create a conformational change that potentiates IL-15 recognition by the betagamma(c) receptor on T cells. The enhancing effect of IL-15Ralpha binding may explain why IL-15 normally functions as a cell-associated cytokine. Significantly, the results with IL-2, a soluble cytokine, are quite different; thus, IL-2 function is markedly inhibited by binding to soluble IL-2Ralpha.

Type Journal
ISBN 0027-8424 (Print)
Authors Rubinstein, M. P.;Kovar, M.;Purton, J. F.;Cho, J. H.;Boyman, O.;Surh, C. D.;Sprent, J. :
Garvan Authors Prof Jonathan Sprent
Publisher Name PNAS
Published Date 2006-01-01 00:00:00
Published Volume 103
Published Issue 24
Published Pages 9166-71
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16757567
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?2123_10604/06 Rubinstein PNAS.pdf