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Regulation of growth hormone action by gonadal steroids

Abstract

Sex steroids modulate growth hormone (GH) secretion and action. Estrogen attenuates GH action in a dose- and route-dependent manner by inhibiting GH-regulated endocrine function of the liver. Testosterone amplifies the metabolic action of GH while exhibiting similar but independent effects of its own. The strong modulatory effect of gonadal steroids on GH responsiveness provides insights into the biologic basis of sexual dimorphism in growth, development, and body composition and practical information for the clinical endocrinologist in the treatment of hypopituitary patients.

Type Journal
ISBN 0889-8529 (Print)
Authors Meinhardt, U. J.;Ho, K. K. :
Garvan Authors Prof Ken Ho
Publisher Name ENDOCRIN METAB CLIN
Published Date 2007-01-01 00:00:00
Published Volume 36
Published Issue 1
Published Pages 57-73
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17336734
Status Published In-print