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Neuropeptide Y in the recurrent mossy fiber pathway

Abstract

In the epileptic brain, hippocampal dentate granule cells become synaptically interconnected through the sprouting of mossy fibers. This new circuitry is expected to facilitate epileptiform discharge. Prolonged seizures induce the long-lasting neoexpression of neuropeptide Y (NPY) in mossy fibers. NPY is released spontaneously from recurrent mossy fiber terminals, reduces glutamate release from those terminals by activating presynaptic Y2 receptors, and depresses granule cell epileptiform activity dependent on the recurrent pathway. These effects are much greater in rats than in C57BL/6 mice, despite apparently equivalent mossy fiber sprouting and neoexpression of NPY. This species difference can be explained by contrasting changes in the expression of mossy fiber Y2 receptors; seizures upregulate Y2 receptors in rats but downregulate them in mice. The recurrent mossy fiber pathway may synchronize granule cell discharge more effectively in humans and mice than in rats, due to its lower expression of either NPY (humans) or Y2 receptors (mice).

Type Journal
ISBN 0196-9781 (Print)
Authors Nadler, J. V.;Tu, B.;Timofeeva, O.;Jiao, Y.;Herzog, H. :
Garvan Authors Prof Herbert Herzog
Publisher Name PEPTIDES
Published Date 2007-01-01 00:00:00
Published Volume 28
Published Issue 2
Published Pages 357-64
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17204350
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?2252_11078/07 Nadler Peptides.pdf