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Self/non-self discrimination and the problem of keeping T cells alive

Abstract

Burnet appreciated the requirement for self/non-self discrimination and presciently postulated elimination of auto-aggressive cells during early life. He could not have known that, for T cells, a limited degree of autoreactivity is beneficial for the immune system. Here, we review evidence that recognition of self-components keeps T cells alive and regulates self-tolerance.Immunology and Cell Biology (2008) 86, 54-56; doi:10.1038/sj.icb.7100139; published online 11 December 2007.

Type Journal
ISBN 0818-9641 (Print)
Authors Sprent, J.;Cho, J. H. :
Publisher Name IMMUNOL CELL BIOL
Published Date 2008-01-01 00:00:00
Published Volume 86
Published Issue 1
Published Pages 54-6
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18071359
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?2388_10023/08 sprent ICB 86 54.pdf