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T cell homeostasis

Abstract

The pool of mature T cells comprises a heterogeneous mixture of naive and memory CD4(+) and CD8(+) cells. These cells are long lived at a population level but differ markedly in their relative rates of turnover and survival. Here, we review how contact with exogenous stimuli, notably self MHC ligands and various gamma(c) cytokines, plays a decisive role in controlling normal T cell homeostasis.Immunology and Cell Biology (2008) 86, 312-319; doi:10.1038/icb.2008.12; published online 25 March 2008.

Type Journal
ISBN 0818-9641 (Print)
Authors Sprent, J.;Cho, J. H.;Boyman, O.;Surh, C. D. :
Publisher Name IMMUNOL CELL BIOL
Published Date 2008-01-01 00:00:00
Published Volume 86
Published Issue 4
Published Pages 312-9
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18362947
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?2389_10022/08 Sprent IBC 86 312.pdf