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Effects of human, rat and porcine galanins on cardiac vagal action and blood pressure in the anaesthetised cat

Abstract

Galanin (GAL) is distributed in sympathetic nerves in the cat, and exogenous GAL inhibits cardiac vagal action and lowers blood pressure in this species. This study on anaesthetised cats compares the effects on cardiac vagal action and blood pressure of human, rat and porcine GAL. Human GAL has only recently been sequenced. It is of particular interest as it is not C-terminally amidated, unlike porcine and rat GAL. Many regulatory peptides require a C-terminal amide group for their action. However, human GAL showed similar biological activity to the other (amidated) GALs here. Omission of a single amino acid (Ser6) from rat GAL significantly attenuated both cardiovascular actions studied here.

Type Journal
ISBN 0304-3940 (Print)
Authors Ulman, L. G.;Evans, H. F.;Iismaa, T. P.;Potter, E. K.;McCloskey, D. I.;Shine, J. :
Garvan Authors Prof John Shine
Publisher Name NEUROSCI LETT
Published Date 1992-01-01 00:00:00
Published Volume 136
Published Issue 1
Published Pages 105-8
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1378950
Status Published In-print