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Cell cycle control by steroid hormones

Abstract

Steroid hormones have well documented stimulatory and inhibitory effects on target cell proliferation. These effects are steroid- and target cell-specific and are mediated by cell cycle phase-specific actions. The molecular mechanisms by which steroids control rates of cell cycle progression are, however, not well defined. Recent advances in our understanding of cell cycle control by proto-oncogenes, tumor suppressor genes and cyclin dependent kinases provide models for further delineating the molecular basis of proliferation control by steroids. Transcriptional activation of c-fos, c-myc and cyclin D1 by estrogens and progestins in breast cancer cells and inhibition of expression of these genes by antiestrogens provide a paradigm for further understanding cell cycle control by steroids.

Type Journal
ISBN 1044-579X (Print)
Authors Musgrove, E. A.;Sutherland, R. L. :
Publisher Name SEMIN CANCER BIOL
Published Date 1994-01-01 00:00:00
Published Volume 5
Published Issue 5
Published Pages 381-9
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7849266
Status Published In-print