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Involvement of RB-1, p53, p16INK4 and telomerase in immortalisation of human cells

Abstract

Involvement of the retinoblastoma susceptibility (RB-1), p16INK4, p53 and telomerase genes in immortalisation was examined by determining their status in 15 human cell lines representing four immortalisation complementation groups. No abnormalities of RB-1, p53 and p16INK4 were detected in cell lines containing DNA tumour virus proteins known to bind to the protein products of the RB-1 and p53 genes. In contrast, in all other cell lines from each of the four groups either RB-1 was mutant or p16INK4 protein was undetectable and there were cell lines containing p53 mutations in three of the groups. Telomerase activity was detected in 12/15 lines, including some of the virally immortalised lines and in some lines from each group. Since none of these changes correlated with complementation group, other genetic changes must be required for immortalisation.

Type Journal
ISBN 0950-9232 (Print)
Authors Whitaker, N. J.;Bryan, T. M.;Bonnefin, P.;Chang, A. C.;Musgrove, E. A.;Braithwaite, A. W.;Reddel, R. R. :
Publisher Name ONCOGENE
Published Date 1995-01-01 00:00:00
Published Volume 11
Published Issue 5
Published Pages 971-6
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7675456
Status Published In-print