Apoptosis
Oestrogen not only causes breast cancer cells to proliferate, but it also protects them from apoptosis (cell death). We are investigating how this occurs and identifying the genes that regulate this process. This will enable us to understand how these genes may influence the way anti-oestrogens such as tamoxifen can effectively kill breast tumour cells. Other projects include examining how novel compounds derived from plants induce apoptosis in breast cancer cells. This could lead to their development as new therapies for the treatment of breast and other cancers.
Current projects include defining the molecular mechanisms of estrogen- and antiestrogen-mediated survival/apoptosis in breast cancer models, and characterising the apoptotic effects of novel therapeutics for breast cancer.
Staff
 Research AssistantCaroline Roberts |
 Postgraduate StudentLuke Anderson |
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