Campbell
People at high risk for the development of type 2 diabetes (i.e. normal glucose tolerant, healthy, first degree relatives of patients with type 2 diabetes) exhibit features of insulin resistance, whereas subjects without any family history of diabetes do not. Type 2 diabetes is a complex disease that is polygenic and subject to multiple environmental influences. By studying a carefully characterised population well before diabetes develops, it may be possible to unravel the complex array of factors that contribute to the condition.
Much of our work makes use of tissue biopsies to study the early changes in fat cells and in muscle that precede type 2 diabetes.
Staff
Dr Dorit Samocha Bonet |
Dr Leonie Heilbronn |
Dr Alex Viardot |
Research Officer Dr Haiyan Li (Jane) |
Lynne Schofield |
Visiting Research Fellow Dr Lisa Sze |
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News
Low levels of PYY hormone a very early indicator of Type 2 diabetes
MEDIA RELEASE:
10 Mar 2008
Garvan scientists have published findings showing that low levels of the hormone PYY could be used as a predictor for the development of Type 2 diabetes. Clinical studies have shown that people with a family history of Type 2 diabetes, but not yet showing signs of insulin resistance themselves, produce lower levels of PYY after eating, a very early sign of pre-diabetes.
