Cell Cycle
Female steroid hormones like oestrogen and progesterone strongly influence cell reproduction in the breast. We are particularly interested in how these hormones act on the cell cycle machinery and how control over the cell cycle is lost in breast cancer cells. In collaboration with the Steroid Hormone Action and Breast Cancer Translational Groups, we are also searching for new genes that might link oestrogen action with the cell cycle and so could be involved in resistance to the anti-oestrogen, tamoxifen, in the clinic. To do this we are using functional genetic screens where we assay the effects of individually altering many genes, and large-scale studies of changes in gene expression after oestrogen treatment.
Staff
 Research OfficerDr Liz Caldon |
 Research AssistantMarcelo Sergio |
 Research AssistantChristine Lee |
News
Calculating how breast cancers will respond to tamoxifen
MEDIA RELEASE:
08 Sep 2008
A discovery by Garvan scientists should help clinicians decide which women with breast cancer will make good candidates for anti-oestrogen therapies, such as tamoxifen, and which will not.
