Integrin and Cell Biology
The signaling pathways that control normal development are often disrupted during cancer. Our research aims to understanding the mechanisms behind the regulation of cell fate decisions during these processes and the progression to metastatic disease. Cell-matrix adhesion mediated by integrins, provides cells with both a positional identity and coordinates growth factor and hormone signaling to control cell function. The initiation and progression of cancer is dependent on the ability of a cell to acquire the means to circumvent this regulation and as such modulation of integrin function can alter tumour phenotype. We are currently investigating integrin function during mammary and prostate gland development and in experimental models of carcinogenesis and metastasis. In addition we are also investigating the role of several cell fate transcriptional regulators also during mammary gland development, cancer and metastasis.
Staff
 Research OfficerDr Renee Rogers |
 Research OfficerDr Kim Moran-Jones |
 Research
AssistantAnita Ledger |
 Undergraduate StudentSarah Scheuer |
