James
One of the major actions of insulin that becomes defective in type 2 diabetes is the regulated entry of nutrients into our muscle and fat cells. Our goal is to use our newly-developed molecular imaging methods to uncover the path that insulin takes from when it binds to muscle and fat cells to when it encounters its final target, and how it achieves its ultimate goal: allowing glucose to gain entry to a cell. Numerous proteins interact with insulin and glucose on this journey. We are also intrigued by the constant movement of proteins within cells, the direction and rate of which is precisely controlled and are investigating the mechanism for the regulation of protein trafficking.
Staff
 Senior Research OfficerDr Jacqueline Stoeckli |
 Research OfficerDr James Burchfield (50% with Hughes Group) |
 Research OfficerDr Shixiong Tan |
 Research OfficerDr Matt Prior |
 Research OfficerDr Daniel Fazakerley |
 Research OfficerDr Yvonne Ng |
 Research OfficerDr Xiuquan Ma |
 Research OfficerDr Guang Yang |
 Research AssistantHimani Joshi |
 Research AssistantAnagha Killedar |
 PhD StudentChristopher Meoli |
 PhD StudentSophie Trefely |
 PhD StudentSamantha Hocking |
 PhD StudentKatherine Tonks |
 PhD StudentSean Humphrey |
 PhD StudentPoh Sim Khoo |
| Visiting Scientist Dr Adele Coster Dr Jai Li Visiting Students Rob Lawrence Pengyi Yang |
 PhD StudentAnnabel Minard |
| Honorary Researcher Prof James Chin |
News
Deconstructing diabetes – why one size does not fit all
MEDIA RELEASE:
30 Nov 2011
Professor David James, Head of the Diabetes and Obesity Program at Garvan, believes it’s time to draw attention to the many things we don’t yet know about the complex metabolic disease we call ‘Type 2 diabetes’, and to the oversimplifications that abound in discussion of future treatments.
Exploring the amazing little world of the fat cell
MEDIA RELEASE:
28 Sep 2011
For the first time, Australian scientists have detailed the proteins, or functional molecules, inside and around the ‘plasma membrane’ of a fat cell, the permeable barrier between the cell’s inner workings and the rest of the body. Understanding the way that proteins function at the surface of these cells will help us unravel some of the complexities underlying Type 2 diabetes.
Garvan Scientists acknowledged on World Diabetes Day
14 Nov 2010
Garvan diabetes research has been recognised by the Diabetes Australia Research Trust, which announced that several Garvan scientists would be receiving significant research support over the coming two years.
