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One of the major actions of insulin that becomes defective in type 2 diabetes is the regulated entry of nutrients into our muscle and fat cells. Our goal is to use our newly-developed molecular imaging methods to uncover the path that insulin takes   from when it binds to muscle and fat cells to when   it encounters its final target, and how it achieves   its ultimate goal: allowing glucose to gain entry   to a cell. Numerous proteins interact with insulin and glucose on this journey. We are also intrigued by the constant movement of proteins within  cells, the direction and rate of which is precisely  controlled and are investigating the mechanism   for the regulation of protein trafficking.

Go to the lab's web site.

 

 

Staff

Jacqueline StoeckliSenior Research Officer
Dr Jacqueline Stoeckli
James BurchfieldResearch Officer
Dr James Burchfield (50% with Hughes Group)
s_tan90.jpgResearch Officer
Dr Shixiong Tan
Matt PriorResearch Officer
Dr Matt Prior
Daniel FazakerleyResearch Officer
Dr Daniel Fazakerley
Yvonne NgResearch Officer
Dr Yvonne Ng
Xiu-Quan MaResearch Officer
Dr Xiuquan Ma
Guang YangResearch Officer
Dr Guang Yang
Himani JoshiResearch Assistant
Himani Joshi
Anagha KilledarResearch Assistant
Anagha Killedar
Christopher MeoliPhD Student
Christopher Meoli
Sophie TrefelyPhD Student
Sophie Trefely
Samantha HockingPhD Student
Samantha Hocking
Dr Katherine TonksPhD Student
Katherine Tonks
Sean HumphreyPhD Student
Sean Humphrey
Poh KhooPhD Student
Poh Sim Khoo
Visiting Scientist
Dr Adele Coster
Dr Jai Li
Visiting Students
Rob Lawrence
Pengyi Yang
Annabel MinardPhD Student
Annabel Minard

Honorary Researcher
Prof James Chin

 

 

 

News

 

Deconstructing diabetes – why one size does not fit all

MEDIA RELEASE: 30 Nov 2011
Professor David James, Head of the Diabetes and Obesity Program at Garvan, believes it’s time to draw attention to the many things we don’t yet know about the complex metabolic disease we call ‘Type 2 diabetes’, and to the oversimplifications that abound in discussion of future treatments.
 
 

Exploring the amazing little world of the fat cell

MEDIA RELEASE: 28 Sep 2011
For the first time, Australian scientists have detailed the proteins, or functional molecules, inside and around the ‘plasma membrane’ of a fat cell, the permeable barrier between the cell’s inner workings and the rest of the body. Understanding the way that proteins function at the surface of these cells will help us unravel some of the complexities underlying Type 2 diabetes.
 
 

Garvan Scientists acknowledged on World Diabetes Day

14 Nov 2010
Garvan diabetes research has been recognised by the Diabetes Australia Research Trust, which announced that several Garvan scientists would be receiving significant research support over the coming two years.
 
 

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