Lung and Colorectal Cancer
We examine the gene profiles of cancer specimens obtained from
patients whose clinical outcomes are already known. The challenge is to
work out which key gene alterations are the most useful for determining
prognosis and treatment outcomes. We have identified new genes that are
inactivated through methylation, a poorly understood molecular
mechanism promoting cancer development. Methylation can be identified
from surgically resected cancers or tumour biopsies in the research
laboratory but this is not routinely carried out in clinical practice.
Our aim is to develop genetic tests that can be applied at the hospital
laboratories. We also want to understand the biological significance of
the gene defects, which will enable development of new treatment
strategies.
Staff
| Research Officer Dr Laurent Pangon |
Nicola Currey |
Tina Selinger |
Dessislava Mladenova |
Nicholas Sigglekow |
PhD Student Yun Si Lim |
| PhD Student Sam Al-Sohaily |
Visiting Scientists Wendy Cooper Joseph Daniel Patricia Kho Jason Tseung |
