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Therapeutic implications of germline genetic findings in cancer
Thavaneswaran, S.; Rath, E.; Tucker, K.; Joshua, A. M.; Hess, D.; Pinese, M.; Ballinger, M. L.; Thomas, D. M.
Nature Reviews Clinical Oncology 16 (6) :386-396, 2019 10.1038/s41571-019-0179-3
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
Coll, R. C.; Hill, J. R.; Day, C. J.; Zamoshnikova, A.; Boucher, D.; Massey, N. L.; Chitty, J. L.; Fraser, J. A.; Jennings, M. P.; Robertson, A. A. B.; Schroder, K.
Nature Chemical Biology 15 (6) :556-559, 2019 10.1038/s41589-019-0277-7
beta Cell Hypoxia-Inducible Factor-1alpha Is Required for the Prevention of Type 1 Diabetes
Lalwani, A.; Warren, J.; Liuwantara, D.; Hawthorne, W. J.; O'Connell, P. J.; Gonzalez, F. J.; Stokes, R. A.; Chen, J.; Laybutt, D. R.; Craig, M. E.; Swarbrick, M. M.; King, C.; Gunton, J. E.
Cell Reports 27 (8) :2370-2384 e6, 2019 10.1016/j.celrep.2019.04.086
Longitudinal Changes in Insulin Resistance in Normal Weight, Overweight and Obese Individuals
Tang, A.; Coster, A. C. F.; Tonks, K. T.; Heilbronn, L. K.; Pocock, N.; Purtell, L.; Govendir, M.; Blythe, J.; Zhang, J.; Xu, A.; Chisholm, D. J.; Johnson, N. A.; Greenfield, J. R.; Samocha-Bonet, D.
Journal of Clinical Medicine 8 (5) :pii: E623, 2019 10.3390/jcm8050623
GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures
Styrkarsdottir, U.; Stefansson, O. A.; Gunnarsdottir, K.; Thorleifsson, G.; Lund, S. H.; Stefansdottir, L.; Juliusson, K.; Agustsdottir, A. B.; Zink, F.; Halldorsson, G. H.; Ivarsdottir, E. V.; Benonisdottir, S.; Jonsson, H.; Gylfason, A.; Norland, K.; Trajanoska, K.; Boer, C. G.; Southam, L.; Leung, J. C. S.; Tang, N. L. S.; Kwok, T. C. Y.; Lee, J. S. W.; Ho, S. C.; Byrjalsen, I.; Center, J. R.; Lee, S. H.; Koh, J. M.; Lohmander, L. S.; Ho-Pham, L. T.; Nguyen, T. V.; Eisman, J. A.; Woo, J.; Leung, P. C.; Loughlin, J.; Zeggini, E.; Christiansen, C.; Rivadeneira, F.; van Meurs, J.; Uitterlinden, A. G.; Mogensen, B.; Jonsson, H.; Ingvarsson, T.; Sigurdsson, G.; Benediktsson, R.; Sulem, P.; Jonsdottir, I.; Masson, G.; Holm, H.; Norddahl, G. L.; Thorsteinsdottir, U.; Gudbjartsson, D. F.; Stefansson, K.
Nature Communications 10 (1) :2054, 2019 10.1038/s41467-019-09860-0
Dietary intake of people with severe mental illness: systematic review and meta-analysis
Teasdale, S. B.; Ward, P. B.; Samaras, K.; Firth, J.; Stubbs, B.; Tripodi, E.; Burrows, T. L.
Br J Psychiatry 214 (5) :251-259, 2019 10.1192/bjp.2019.20
Single-cell transcriptional profiling of aortic endothelium identifies a hierarchy from endovascular progenitors to differentiated cells
Lukowski, S. W.; Patel, J.; Andersen, S. B.; Sim, S. L.; Wong, H. Y.; Tay, J.; Winkler, I.; Powell, J. E.; Khosrotehrani, K.
Cell Reports 27 (9) :2748-2758.e3, 2019 10.1016/j.celrep.2019.04.102
Cyclin Dependent Kinase 2 inhibitors in cancer therapy: an update
Tadesse, S.; Caldon, E. C.; Tilley, W.; Wang, S.
JOURNAL OF MEDICINAL CHEMISTRY 62 (9) :4233-4251, 2019 10.1021/acs.jmedchem.8b01469
Human inborn errors of the actin cytoskeleton affecting immunity: way beyond WAS and WIP
Tangye, S. G.; Bucciol, G.; de Las Casas, J. M.; Pillay, B.; Ma, C. S.; Moens, L.; Meyts, I.
IMMUNOLOGY AND CELL BIOLOGY 97 (4) :389-402, 2019 10.1111/imcb.12243
Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote
Lau, M. T.; Manion, J.; Littleboy, J. B.; Oyston, L.; Khuong, T. M.; Wang, Q. P.; Nguyen, D. T.; Hesselson, D.; Seymour, J. E.; Neely, G. G.
Nature Communications 10 (1) :1655, 2019 10.1038/s41467-019-09681-1
Visualization and Analysis of Epiproteome Dynamics
Kaur, S.; Baldi, B.; Vuong, J.; O'Donoghue, S. I.
JOURNAL OF MOLECULAR BIOLOGY 431 (8) :1519-1539, 2019 10.1016/j.jmb.2019.01.044
The effectiveness of the Keeping the Body in Mind Xtend pilot lifestyle program on dietary intake in first-episode psychosis: Two-year outcomes
Teasdale, S. B.; Curtis, J.; Ward, P. B.; Watkins, A.; Lederman, O.; Rosenbaum, S.; Kalucy, M.; Lappin, J.; Samaras, K.
Obesity Research & Clinical Practice 13 (2) :214-216, 2019 10.1016/j.orcp.2019.02.003
Height and body mass index as modifiers of breast cancer risk in BRCA1/2 mutation carriers: A mendelian randomization study
Qian, F.; Wang, S.; Mitchell, J.; McGuffog, L.; Barrowdale, D.; Leslie, G.; Oosterwijk, J. C.; Chung, W. K.; Evans, D. G.; Engel, C.; Kast, K.; Aalfs, C. M.; Adank, M. A.; Adlard, J.; Agnarsson, B. A.; Aittomaki, K.; Alducci, E.; Andrulis, I. L.; Arun, B. K.; Ausems, Mgem; Azzollini, J.; Barouk-Simonet, E.; Barwell, J.; Belotti, M.; Benitez, J.; Berger, A.; Borg, A.; Bradbury, A. R.; Brunet, J.; Buys, S. S.; Caldes, T.; Caligo, M. A.; Campbell, I.; Caputo, S. M.; Chiquette, J.; Claes, K. B. M.; Margriet Collee, J.; Couch, F. J.; Coupier, I.; Daly, M. B.; Davidson, R.; Diez, O.; Domchek, S. M.; Donaldson, A.; Dorfling, C. M.; Eeles, R.; Feliubadalo, L.; Foretova, L.; Fowler, J.; Friedman, E.; Frost, D.; Ganz, P. A.; Garber, J.; Garcia-Barberan, V.; Glendon, G.; Godwin, A. K.; Gomez Garcia, E. B.; Gronwald, J.; Hahnen, E.; Hamann, U.; Henderson, A.; Hendricks, C. B.; Hopper, J. L.; Hulick, P. J.; Imyanitov, E. N.; Isaacs, C.; Izatt, L.; Izquierdo, A.; Jakubowska, A.; Kaczmarek, K.; Kang, E.; Karlan, B. Y.; Kets, C. M.; Kim, S. W.; Kim, Z.; Kwong, A.; Laitman, Y.; Lasset, C.; Hyuk Lee, M.; Won Lee, J.; Lee, J.; Lester, J.; Lesueur, F.; Loud, J. T.; Lubinski, J.; Mebirouk, N.; Meijers-Heijboer, H. E. J.; Meindl, A.; Miller, A.; Montagna, M.; Mooij, T. M.; Morrison, P. J.; Mouret-Fourme, E.; Nathanson, K. L.; Neuhausen, S. L.; Nevanlinna, H.; Niederacher, D.; Nielsen, F. C.; Nussbaum, R. L.; Offit, K., et al.
JNCI-Journal of the National Cancer Institute 111 (4) :350-364, 2019 10.1093/jnci/djy132
Characterization of the ERG-regulated kinome in prostate cancer identifies TNIK as a potential therapeutic target
Lee, R. S.; Zhang, L.; Berger, A.; Lawrence, M. G.; Song, J.; Niranjan, B.; Davies, R. G.; Lister, N. L.; Sandhu, S. K.; Rubin, M. A.; Risbridger, G. P.; Taylor, R. A.; Rickman, D. S.; Horvath, L. G.; Daly, R. J.
NEOPLASIA 21 (4) :389-400, 2019 10.1016/j.neo.2019.02.005
Combating pancreatic cancer with PI3K pathway inhibitors in the era of personalised medicine
Conway, J. R.; Herrmann, D.; Evans, T. J.; Morton, J. P.; Timpson, P.
GUT 68 (4) :742-758, 2019 10.1136/gutjnl-2018-316822