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A 5alpha-reductase (SRD5A2) polymorphism is associated with serum testosterone and sex hormone-binding globulin in men, while aromatase (CYP19A1) polymorphisms are associated with oestradiol and luteinizing hormone reciprocally
Yeap, B. B.; Knuiman, M. W.; Handelsman, D. J.; Ho, K. K. Y.; Hui, J.; Divitini, M. L.; Arscott, G. M.; McQuillan, B.; Hung, J.; Beilby, J. P.
CLINICAL ENDOCRINOLOGY 90 (2) :301-311, 2019 10.1111/cen.13885
Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance
Brandon, A. E.; Liao, B. M.; Diakanastasis, B.; Parker, B. L.; Raddatz, K.; McManus, S. A.; O'Reilly, L.; Kimber, E.; van der Kraan, A. G.; Hancock, D.; Henstridge, D. C.; Meikle, P. J.; Cooney, G. J.; James, D. E.; Reibe, S.; Febbraio, M. A.; Biden, T. J.; Schmitz-Peiffer, C.
Cell Metabolism 29 (1) :183-191 e7, 2019 10.1016/j.cmet.2018.09.013
How we approach: Severe congenital neutropenia and myelofibrosis due to mutations in VPS45
Shadur, B.; Asherie, N.; Newburger, P. E.; Stepensky, P.
PEDIATRIC BLOOD & CANCER 66 (1) :e27473, 2019 10.1002/pbc.27473
Redefining tissue cross-talk via shotgun proteomic analyses of plasma extracellular vesicles
Whitham, M.; Febbraio, M. A.
PROTEOMICS :e1800154, 2019 10.1002/pmic.201800154
Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass
Cantley, J.; Davenport, A.; Vetterli, L.; Nemes, N. J.; Whitworth, P. T.; Boslem, E.; Thai, L. M.; Mellett, N.; Meikle, P. J.; Hoehn, K. L.; James, D. E.; Biden, T. J.
DIABETOLOGIA 62 (1) :99-111, 2019 10.1007/s00125-018-4743-7
Activating PIK3CD mutations impair human cytotoxic lymphocyte differentiation and function, and EBV immunity
Edwards ESJ, Bier J, Cole TS, Wong M, Hsu P, Berglund LJ, Boztug K, Lau A, Gostick E, Price DA, O'Sullivan M, Meyts I, Choo S, Gray P, Holland SM, Deenick EK, Uzel G, Tangye SG
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 143 (1) :276-291, 2019 https://doi.org/10.1016/j.jaci.2018.04.030
The extracellular matrix as a key regulator of intracellular signalling networks
Hastings, J. F.; Skhinas, J. N.; Fey, D.; Croucher, D. R.; Cox, T. R.
BRITISH JOURNAL OF PHARMACOLOGY 176 (1) :82-92, 2019 10.1111/bph.14195
Parafibromin-deficient (HPT-JT type, CDC73 mutated) parathyroid tumors demonstrate distinctive morphologic features
Gill, A. J.; Lim, G.; Cheung, V. K. Y.; Andrici, J.; Perry-Keene, J. L.; Paik, J.; Sioson, L.; Clarkson, A.; Sheen, A.; Luxford, C.; Elston, M. S.; Meyer-Rochow, G. Y.; Nano, M. T.; Kruijff, S.; Engelsman, A. F.; Sywak, M.; Sidhu, S. B.; Delbridge, L. W.; Robinson, B. G.; Marsh, D. J.; Toon, C. W.; Chou, A.; Clifton-Bligh, R. J.
American Journal Of Surgical Pathology 43 (1) :35-46, 2019 10.1097/PAS.0000000000001017
Health status, emergency department visits, and oncologists' feedback: An analysis of secondary endpoints from a randomized phase II geriatric assessment trial
Sattar, S.; Alibhai, S. M. H.; Brennenstuhl, S.; Kulik, M.; MacDonald, M. E.; McWatters, K.; Lee, K.; Jang, R.; Amir, E.; Krzyzanowska, M. K.; Joshua, A. M.; Monette, J.; Wan-Chow-Wah, D.; Puts, M. T. E.
Journal of Geriatric Oncology 10 (1) :169-174, 2019 10.1016/j.jgo.2018.06.014
Transcriptomics and single-cell RNA-sequencing
Chambers, D. C.; Carew, A. M.; Lukowski, S. W.; Powell, J. E.
RESPIROLOGY 24 (1) :29-36, 2019 10.1111/resp.13412
Autism spectrum disorder: insights into convergent mechanisms from transcriptomics
Quesnel-Vallieres, M.; Weatheritt, R. J.; Cordes, S. P.; Blencowe, B. J.
NATURE REVIEWS GENETICS 20 (1) :51-63, 2019 10.1038/s41576-018-0066-2
Serum Free Methylated Glutathione S-transferase 1 DNA Levels, Survival, and Response to Docetaxel in Metastatic, Castration-resistant Prostate Cancer: Post Hoc Analyses of Data from a Phase 3 Trial
Mahon, K. L.; Qu, W.; Lin, H. M.; Spielman, C.; Cain, D.; Jacobs, C.; Stockler, M. R.; Higano, C. S.; de Bono, J. S.; Chi, K. N.; Clark, S. J.; Horvath, L. G.
EUROPEAN UROLOGY S0302-2838 (18) :30855-8, 2019 10.1016/j.eururo.2018.11.001
Myeloid cell leukemia 1 (MCL-1), an unexpected modulator of protein kinase signaling during invasion
Young, A. I.; Timpson, P.; Gallego-Ortega, D.; Ormandy, C. J.; Oakes, S. R.
Cell Adhesion & Migration 12 (6) :513-523, 2018 10.1080/19336918.2017.1393591
Tumor Cell Dormancy and Reactivation in Bone: Skeletal Biology and Therapeutic Opportunities
Byrne, N.M., Summers, M.A. and McDonald, M.M.
JOURNAL OF BONE AND MINERAL RESEARCH PLUS 2018 10.1002/jbm4.10125
Comparison of 4 commercial kits for the extraction of circulating DNA from plasma
Warton, K.; Graham, L. J.; Yuwono, N.; Samimi, G.
Cancer Genetics 228-229 :143-150, 2018 10.1016/j.cancergen.2018.02.004