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90 items matching your search terms.
Activating mutations in PIK3CD disrupt the differentiation and function of human and murine CD4(+) T cells
Bier, J.; Rao, G.; Payne, K.; Brigden, H.; French, E.; Pelham, S. J.; Lau, A.; Lenthall, H.; Edwards, E. S. J.; Smart, J. M.; Cole, T. S.; Choo, S.; Joshi, A. Y.; Abraham, R. S.; O'Sullivan, M.; Boztug, K.; Meyts, I.; Gray, P. E.; Berglund, L. J.; Hsu, P.; Wong, M.; Holland, S. M.; Notarangelo, L. D.; Uzel, G.; Ma, C. S.; Brink, R.; Tangye, S. G.; Deenick, E. K.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 144 (1) :236-253, 2019 10.1016/j.jaci.2019.01.033
Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes
Moran, I.; Nguyen, A.; Khoo, W. H.; Butt, D.; Bourne, K.; Young, C.; Hermes, J. R.; Biro, M.; Gracie, G.; Ma, C. S.; Munier, C. M. L.; Luciani, F.; Zaunders, J.; Parker, A.; Kelleher, A. D.; Tangye, S. G.; Croucher, P. I.; Brink, R.; Read, M. N.; Phan, T. G.
Nature Communications 9 (1) :3372, 2018 10.1038/s41467-018-05772-7
Germline-activating mutations in PIK3CD compromise B cell development and function
Avery, D. T.; Kane, A.; Nguyen, T.; Lau, A.; Nguyen, A.; Lenthall, H.; Payne, K.; Shi, W.; Brigden, H.; French, E.; Bier, J.; Hermes, J. R.; Zahra, D.; Sewell, W. A.; Butt, D.; Elliott, M.; Boztug, K.; Meyts, I.; Choo, S.; Hsu, P.; Wong, M.; Berglund, L. J.; Gray, P.; O'Sullivan, M.; Cole, T.; Holland, S. M.; Ma, C. S.; Burkhart, C.; Corcoran, L. M.; Phan, T. G.; Brink, R.; Uzel, G.; Deenick, E. K.; Tangye, S. G.
JOURNAL OF EXPERIMENTAL MEDICINE 215 (8) :2073-2095, 2018 10.1084/jem.20180010
SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation
Thientosapol, E. S.; Bosnjak, D.; Durack, T.; Stevanovski, I.; van Geldermalsen, M.; Holst, J.; Jahan, Z.; Shepard, C.; Weninger, W.; Kim, B.; Brink, R.; Jolly, C. J.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 115 (19) :4921-4926, 2018 10.1073/pnas.1719771115
Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination
Burnett, D. L.; Langley, D. B.; Schofield, P.; Hermes, J. R.; Chan, T. D.; Jackson, J.; Bourne, K.; Reed, J. H.; Patterson, K.; Porebski, B. T.; Brink, R.; Christ, D.; Goodnow, C. C.
SCIENCE 360 (6385) :223-226, 2018 10.1126/science.aao3859
Self-Reactive B Cells in the Germinal Center Reaction
Brink, R.; Phan, T. G.
Annual Review of Immunology 36 :339-357, 2018 10.1146/annurev-immunol-051116-052510
Atypical chemokine receptor 4 shapes activated B cell fate
Kara, E. E.; Bastow, C. R.; McKenzie, D. R.; Gregor, C. E.; Fenix, K. A.; Babb, R.; Norton, T. S.; Zotos, D.; Rodda, L. B.; Hermes, J. R.; Bourne, K.; Gilchrist, D. S.; Nibbs, R. J.; Alsharifi, M.; Vinuesa, C. G.; Tarlinton, D. M.; Brink, R.; Hill, G. R.; Cyster, J. G.; Comerford, I.; McColl, S. R.
JOURNAL OF EXPERIMENTAL MEDICINE 215 (3) :801-813, 2018 10.1084/jem.20171067
GPR65 inhibits experimental autoimmune encephalomyelitis through CD4(+) T cell independent mechanisms that include effects on iNKT cells
Wirasinha, R. C.; Vijayan, D.; Smith, N. J.; Parnell, G. P.; Swarbrick, A.; Brink, R.; King, C.; Stewart, G.; Booth, D. R.; Batten, M.
IMMUNOLOGY AND CELL BIOLOGY 96 (2) :128-136, 2018 10.1111/imcb.1031
CCR6 defines memory B cell precursors in mouse and human germinal centers revealing light zone location and predominant low antigen affinity.
Suan, D.; Krautler, N.J.; Maag, J.L.V.; Butt, D.; Bourne, K.; Hermes, J.R.; Avery, D.T.; Young, C.; Statham, A.; Elliott, M.; Dinger, M.E.; Basten, A.; Tangye, S.G.; Brink, R.
IMMUNITY 47 (6) :1142-1153, 2017 10.1016/j.immuni.2017.11.022
Structural basis of antigen recognition: crystal structure of duck egg lysozyme
Langley, D. B.; Crossett, B.; Schofield, P.; Jackson, J.; Zeraati, M.; Maltby, D.; Christie, M.; Burnett, D.; Brink, R.; Goodnow, C.; Christ, D.
Acta Crystallographica Section D-Structural Biology 73 (Pt 11) :910-920, 2017 10.1107/S2059798317013730
OpenAccess publication Murine LRBA-deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation
Burnett, D.; Parish, I.; Masle-Farquhar, E.; Brink, R.; Goodnow, C.
IMMUNOLOGY AND CELL BIOLOGY 95 (9) :755-788, 2017 10.1038/icb.2017.50
IL-2 Shapes the Survival and Plasticity of IL-17-Producing gammadelta T Cells
Corpuz, T. M.; Vazquez-Lombardi, R.; Luong, J. K.; Warren, J.; Stolp, J.; Christ, D.; King, C.; Brink, R.; Sprent, J.; Webster, K. E.
JOURNAL OF IMMUNOLOGY 199 (7) :2366-2376, 2017 10.4049/jimmunol.1700335
OpenAccess publication In vivo photolabeling of tumor-infiltrating cells reveals highly regulated egress of T-cell subsets from tumors.
Torcellan, T.; Hampton, HR.; Bailey, J.; Tomura, M.; Brink, R.; Chtanova, T.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 144 (22) :5677-5682, 2017 10.1073/pnas.1618446114
OpenAccess publication Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells
KrA$?utler, NJ.; Suan, D.; Butt, D.; Bourne, K.; Hermes, JR.; Chan, TD.; Sundling, C.; Kaplan, W.; Schofield, P.; Jackson, J.; Basten, A.; Christ, D.; Brink, R.
JOURNAL OF EXPERIMENTAL MEDICINE 214 (5) :1259-1267, 2017 10.1084/jem.20161533
OpenAccess publication Plasma cell and memory B cell differentiation from the germinal center.
Suan, D.; Sundling, C.; Brink, R.
CURRENT OPINION IN IMMUNOLOGY 45 :97-102, 2017 10.1016/j.coi.2017.03.006