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34 items matching your search terms.
A zebrafish functional genomics model to investigate the role of human A20 variants in vivo
Cultrone, D.; Zammit, N. W.; Self, E.; Postert, B.; Han, J. Z. R.; Bailey, J.; Warren, J.; Croucher, D. R.; Kikuchi, K.; Bogdanovic, O.; Chtanova, T.; Hesselson, D.; Grey, S. T.
Scientific Reports 10 (1) :19085, 2020 10.1038/s41598-020-75917-6.
Histone deacetylases and histone deacetylase inhibitors in neuroblastoma
Phimmachanh, M.; Han, J. Z. R.; O'Donnell, Y. E. I.; Latham, S. L.; Croucher, D. R.
Front Cell Dev Biol 8 :578770, 2020 10.3389/fcell.2020.578770
A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers
Filipcik, P.; Latham, S. L.; Cadell, A. L.; Day, C. L.; Croucher, D. R.; Mace, P. D.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 117 (35) :21308-21318, 2020 10.1073/pnas.2006429117
Myosin-18B regulates higher-order organization of the cardiac sarcomere through thin filament cross-linking and thick filament dynamics
Latham, S. L.; Weiss, N.; Schwanke, K.; Thiel, C.; Croucher, D. R.; Zweigerdt, R.; Manstein, D. J.; Taft, M. H.
Cell Reports 32 (9) :108090, 2020 10.1016/j.celrep.2020.108090
Applications of personalised signalling network models in precision oncology
Hastings, J. F.; O'Donnell, Y. E. I.; Fey, D.; Croucher, D. R.
PHARMACOLOGY & THERAPEUTICS 212 :107555, 2020 10.1016/j.pharmthera.2020.107555
OpenAccess publication Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma
Hastings, J. F.; Gonzalez Rajal, A.; Latham, S. L.; Han, J. Z.; McCloy, R. A.; O'Donnell, Y. E.; Phimmachanh, M.; Murphy, A. D.; Nagrial, A.; Daneshvar, D.; Chin, V.; Watkins, D. N.; Burgess, A.; Croucher, D. R.
eLife 9 :e53367, 2020 10.7554/eLife.53367
MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer
Cipponi, A.; Goode, D. L.; Bedo, J.; McCabe, M. J.; Pajic, M.; Croucher, D. R.; Rajal, A. G.; Junankar, S. R.; Saunders, D. N.; Lobachevsky, P.; Papenfuss, A. T.; Nessem, D.; Nobis, M.; Warren, S. C.; Timpson, P.; Cowley, M.; Vargas, A. C.; Qiu, M. R.; Generali, D. G.; Keerthikumar, S.; Nguyen, U.; Corcoran, N. M.; Long, G. V.; Blay, J. Y.; Thomas, D. M.
SCIENCE 368 (6495) :1127-1131, 2020 10.1126/science.aau8768
Breathing New Life into the Mechanisms of Platinum Resistance in Lung Adenocarcinoma
Gonzalez-Rajal, A.; Hastings, J. F.; Watkins, D. N.; Croucher, D. R.; Burgess, A.
Frontiers in Cell and Developmental Biology 8 :305, 2020 10.3389/fcell.2020.00305
Structure-based mechanism of preferential complex formation by apoptosis signal-regulating kinases
Trevelyan, S. J.; Brewster, J. L.; Burgess, A. E.; Crowther, J. M.; Cadell, A. L.; Parker, B. L.; Croucher, D. R.; Dobson, R. C. J.; Murphy, J. M.; Mace, P. D.
Science Signaling 13 (622) 2020 10.1126/scisignal.aay6318
OpenAccess publication CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan
Vennin, C.; Melenec, P.; Rouet, R.; Nobis, M.; Cazet, A. S.; Murphy, K. J.; Herrmann, D.; Reed, D. A.; Lucas, M. C.; Warren, S. C.; Elgundi, Z.; Pinese, M.; Kalna, G.; Roden, D.; Samuel, M.; Zaratzian, A.; Grey, S. T.; Da Silva, A.; Leung, W.; Mathivanan, S.; Wang, Y.; Braithwaite, A. W.; Christ, D.; Benda, A.; Parkin, A.; Phillips, P. A.; Whitelock, J. M.; Gill, A. J.; Sansom, O. J.; Croucher, D. R.; Parker, B. L.; Pajic, M.; Morton, J. P.; Cox, T. R.; Timpson, P.
Nature Communications 10 (1) :3637, 2019 10.1038/s41467-019-10968-6
OpenAccess publication Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer
Kennedy, S. P.; Han, J. Z. R.; Portman, N.; Nobis, M.; Hastings, J. F.; Murphy, K. J.; Latham, S. L.; Cadell, A. L.; Miladinovic, D.; Marriott, G. R.; O'Donnell, Y. E. I.; Shearer, R. F.; Williams, J. T.; Munoz, A. G.; Cox, T. R.; Watkins, D. N.; Saunders, D. N.; Timpson, P.; Lim, E.; Kolch, W.; Croucher, D. R.
BREAST CANCER RESEARCH 21 (1) :43, 2019 10.1186/s13058-019-1127-y
The extracellular matrix as a key regulator of intracellular signalling networks
Hastings, J. F.; Skhinas, J. N.; Fey, D.; Croucher, D. R.; Cox, T. R.
BRITISH JOURNAL OF PHARMACOLOGY 176 (1) :82-92, 2019 10.1111/bph.14195
MASTL overexpression promotes chromosome instability and metastasis in breast cancer
Rogers, S.; McCloy, R. A.; Parker, B. L.; Gallego-Ortega, D.; Law, A. M. K.; Chin, V. T.; Conway, J. R. W.; Fey, D.; Millar, E. K. A.; O'Toole, S.; Deng, N.; Swarbrick, A.; Chastain, P. D.; Cesare, A. J.; Timpson, P.; Caldon, C. E.; Croucher, D. R.; James, D. E.; Watkins, D. N.; Burgess, A.
ONCOGENE 37 (33) :4518-4533, 2018 10.1038/s41388-018-0295-z
Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy
Marini, K. D.; Croucher, D. R.; McCloy, R. A.; Vaghjiani, V.; Gonzalez-Rajal, A.; Hastings, J. F.; Chin, V.; Szczepny, A.; Kostyrko, K.; Marquez, C.; Jayasekara, W. S. N.; Alamgeer, M.; Boolell, V.; Han, J. Z. R.; Waugh, T.; Lee, H. C.; Oakes, S. R.; Kumar, B.; Harrison, C. A.; Hedger, M. P.; Lorensuhewa, N.; Kita, B.; Barrow, R.; Robinson, B. W.; de Kretser, D. M.; Wu, J.; Ganju, V.; Sweet-Cordero, E. A.; Burgess, A.; Martelotto, L. G.; Rossello, F. J.; Cain, J. E.; Watkins, D. N.
Science Translational Medicine 10 (451) :eaat3504, 2018 10.1126/scitranslmed.aat3504
OpenAccess publication Dissecting multi-protein signaling complexes by Bimolecular Complementation Affinity Purification (BiCAP)
Hastings, J. F.; Han, J. Z. R.; Shearer, R. F.; Kennedy, S. P.; Iconomou, M.; Saunders, D. N.; Croucher, D. R.
Jove-Journal of Visualized Experiments (136) :e57109, 2018 10.3791/57109
OpenAccess publication Intravital imaging to monitor therapeutic response in moving hypoxic regions resistant to PI3K pathway targeting in pancreatic cancer
Conway, J. R. W.; Warren, S. C.; Herrmann, D.; Murphy, K. J.; Cazet, A. S.; Vennin, C.; Shearer, R. F.; Killen, M. J.; Magenau, A.; Melenec, P.; Pinese, M.; Nobis, M.; Zaratzian, A.; Boulghourjian, A.; Da Silva, A. M.; Del Monte-Nieto, G.; Adam, A. S. A.; Harvey, R. P.; Haigh, J. J.; Wang, Y.; Croucher, D. R.; Sansom, O. J.; Pajic, M.; Caldon, C. E.; Morton, J. P.; Timpson, P.
Cell Reports 23 (11) :3312-3326, 2018 10.1016/j.celrep.2018.05.038