Garvan Institute of Medical Research

CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1(+) ICOS(high) activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells

Masle-Farquhar, E.; Jeelall, Y.; White, J.; Bier, J.; Deenick, E. K.; Brink, R.; Horikawa, K.; Goodnow, C. C.

Frontiers in Immunology 14 :1095257, 2023 10.3389/fimmu.2023.1095257

Phosphatidylinositol 3-kinase signaling and immune regulation: insights into disease pathogenesis and clinical implications

Nguyen, T.; Deenick, E. K.; Tangye, S. G.

Expert Review of Clinical Immunology 17 (8) :905-914, 2021 10.1080/1744666X.2021.1945443

Genomic Spectrum and Phenotypic Heterogeneity of Human IL-21 Receptor Deficiency

Cagdas, D. Mayr, D. Baris, S. Worley, L. Langley, D. B. Metin, A. Aytekin, E. S. Atan, R. Kasap, N. Bal, S. K. Dmytrus, J. Heredia, R. J. Karasu, G. Torun, S. H. Toyran, M. Karakoc-Aydiner, E. Christ, D. Kuskonmaz, B. Uckan-Cetinkaya, D. Uner, A. Oberndorfer, F. Schiefer, A. I. Uzel, G. Deenick, E. K. Keller, B. Warnatz, K. Neven, B. Durandy, A. Sanal, O. Ma, C. S. Ozen, A. Stepensky, P. Tezcan, I. Boztug, K. Tangye, S. G.

JOURNAL OF CLINICAL IMMUNOLOGY 2021 10.1007/s10875-021-01031-5

B cells: we need them now more than ever.

Deenick, E.K

IMMUNOLOGY AND CELL BIOLOGY 98 (6) :437-438, 2020 https://doi.org/10.1111/imcb.12348

Molecular and cellular mechanisms underlying defective antibody responses.

Deenick, E.K.; Lau, A.; Bier, J.; Kane, A.

IMMUNOLOGY AND CELL BIOLOGY 98 (6) :467-479, 2020 https://doi.org/10.1111/imcb.12345

NK Cells Regulate CD8(+) T Cell Mediated Autoimmunity

Lang, P. A.; Crome, S. Q.; Xu, H. C.; Lang, K. S.; Chapatte, L.; Deenick, E. K.; Grusdat, M.; Pandyra, A. A.; Pozdeev, V. I.; Wang, R.; Holderried, T. A. W.; Cantor, H.; Diefenbach, A.; Elford, A. R.; McIlwain, D. R.; Recher, M.; Haussinger, D.; Mak, T. W.; Ohashi, P. S.

Frontiers in Cellular and Infection Microbiology 10 :36, 2020 10.3389/fcimb.2020.00036

Activated PI3Kdelta breaches multiple B cell tolerance checkpoints and causes autoantibody production

Lau, A.; Avery, D. T.; Jackson, K.; Lenthall, H.; Volpi, S.; Brigden, H.; Russell, A. J.; Bier, J.; Reed, J. H.; Smart, J. M.; Cole, T.; Choo, S.; Gray, P. E.; Berglund, L. J.; Hsu, P.; Wong, M.; O'Sullivan, M.; Boztug, K.; Meyts, I.; Uzel, G.; Notarangelo, L. D.; Brink, R.; Goodnow, C. C.; Tangye, S. G.; Deenick, E. K.

JOURNAL OF EXPERIMENTAL MEDICINE 217 (2) :e20191336, 2020 10.1084/jem.20191336

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

Koay, H. F.; Su, S.; Amann-Zalcenstein, D.; Daley, S. R.; Comerford, I.; Miosge, L.; Whyte, C. E.; Konstantinov, I. E.; d'Udekem, Y.; Baldwin, T.; Hickey, P. F.; Berzins, S. P.; Mak, J. Y. W.; Sontani, Y.; Roots, C. M.; Sidwell, T.; Kallies, A.; Chen, Z.; Nussing, S.; Kedzierska, K.; Mackay, L. K.; McColl, S. R.; Deenick, E. K.; Fairlie, D. P.; McCluskey, J.; Goodnow, C. C.; Ritchie, M. E.; Belz, G. T.; Naik, S. H.; Pellicci, D. G.; Godfrey, D. I.

Science Immunology 4 (41) :eaay6039, 2019 10.1126/sciimmunol.aay6039

Activating mutations in PIK3CD disrupt the differentiation and function of human and murine CD4(+) T cells

Bier, J.; Rao, G.; Payne, K.; Brigden, H.; French, E.; Pelham, S. J.; Lau, A.; Lenthall, H.; Edwards, E. S. J.; Smart, J. M.; Cole, T. S.; Choo, S.; Joshi, A. Y.; Abraham, R. S.; O'Sullivan, M.; Boztug, K.; Meyts, I.; Gray, P. E.; Berglund, L. J.; Hsu, P.; Wong, M.; Holland, S. M.; Notarangelo, L. D.; Uzel, G.; Ma, C. S.; Brink, R.; Tangye, S. G.; Deenick, E. K.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 144 (1) :236-253, 2019 10.1016/j.jaci.2019.01.033

B cell-intrinsic requirement for STK4 in humoral immunity in mice and human subjects

Moran, I.; Avery, D. T.; Payne, K.; Lenthall, H.; Davies, E. G.; Burns, S.; Ip, W.; Oleastro, M. M.; Reisli, I.; Guner, S.; Keles, S.; Notarangelo, L.; Deenick, E. K.; Goodnow, C. C.; Zahra, D.; Brink, R.; Circa; Wong, M.; Tangye, S. G.; Ma, C. S.; Phan, T. G.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 143 (6) :2302-2305, 2019 10.1016/j.jaci.2019.02.010

B cell-intrinsic requirement for STK4 in humoral immunity in mice and humans

Moran, I.; Avery, D. T.; Payne, K.; Lenthall, H.; Davies, E. G.; Burns, S.; Ip, W.; Oleastro, M. M.; Reisli, I.; Guner, S.; Keles, S.; Notarangelo, L.; Deenick, E. K.; Goodnow, C. C.; Zahra, D.; Brink, R.; Circa; Wong, M.; Tangye, S. G.; Ma, C. S.; Phan, T. G.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 143 (6) :2302-2305, 2019 10.1016/j.jaci.2019.02.010

Immune Dysregulation and Disease Pathogenesis due to Activating Mutations in PIK3CD-the Goldilocks' Effect

Tangye, S. G.; Bier, J.; Lau, A.; Nguyen, T.; Uzel, G.; Deenick, E. K.

JOURNAL OF CLINICAL IMMUNOLOGY 39 (2) :148-158, 2019 10.1007/s10875-019-00612-9

Activating PIK3CD mutations impair human cytotoxic lymphocyte differentiation and function and EBV immunity

Edwards, E. S. J.; Bier, J.; Cole, T. S.; Wong, M.; Hsu, P.; Berglund, L. J.; Boztug, K.; Lau, A.; Gostick, E.; Price, D. A.; O'Sullivan, M.; Meyts, I.; Choo, S.; Gray, P.; Holland, S. M.; Deenick, E. K.; Uzel, G.; Tangye, S. G.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 143 (1) :276-291 e6, 2019 10.1016/j.jaci.2018.04.030

Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency

Kong, X. F.; Martinez-Barricarte, R.; Kennedy, J.; Mele, F.; Lazarov, T.; Deenick, E. K.; Ma, C. S.; Breton, G.; Lucero, K. B.; Langlais, D.; Bousfiha, A.; Aytekin, C.; Markle, J.; Trouillet, C.; Jabot-Hanin, F.; Arlehamn, C. S. L.; Rao, G.; Picard, C.; Lasseau, T.; Latorre, D.; Hambleton, S.; Deswarte, C.; Itan, Y.; Abarca, K.; Moraes-Vasconcelos, D.; Ailal, F.; Ikinciogullari, A.; Dogu, F.; Benhsaien, I.; Sette, A.; Abel, L.; Boisson-Dupuis, S.; Schroder, B.; Nussenzweig, M. C.; Liu, K.; Geissmann, F.; Tangye, S. G.; Gros, P.; Sallusto, F.; Bustamante, J.; Casanova, J. L.

NATURE IMMUNOLOGY 19 (9) :973-985, 2018 10.1038/s41590-018-0178-z

Germline-activating mutations in PIK3CD compromise B cell development and function

Avery, D. T.; Kane, A.; Nguyen, T.; Lau, A.; Nguyen, A.; Lenthall, H.; Payne, K.; Shi, W.; Brigden, H.; French, E.; Bier, J.; Hermes, J. R.; Zahra, D.; Sewell, W. A.; Butt, D.; Elliott, M.; Boztug, K.; Meyts, I.; Choo, S.; Hsu, P.; Wong, M.; Berglund, L. J.; Gray, P.; O'Sullivan, M.; Cole, T.; Holland, S. M.; Ma, C. S.; Burkhart, C.; Corcoran, L. M.; Phan, T. G.; Brink, R.; Uzel, G.; Deenick, E. K.; Tangye, S. G.

JOURNAL OF EXPERIMENTAL MEDICINE 215 (8) :2073-2095, 2018 10.1084/jem.20180010

A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity

Beziat, V.; Li, J.; Lin, J. X.; Ma, C. S.; Li, P.; Bousfiha, A.; Pellier, I.; Zoghi, S.; Baris, S.; Keles, S.; Gray, P.; Du, N.; Wang, Y.; Zerbib, Y.; Levy, R.; Leclercq, T.; About, F.; Lim, A. I.; Rao, G.; Payne, K.; Pelham, S. J.; Avery, D. T.; Deenick, E. K.; Pillay, B.; Chou, J.; Guery, R.; Belkadi, A.; Guerin, A.; Migaud, M.; Rattina, V.; Ailal, F.; Benhsaien, I.; Bouaziz, M.; Habib, T.; Chaussabel, D.; Marr, N.; El-Benna, J.; Grimbacher, B.; Wargon, O.; Bustamante, J.; Boisson, B.; Muller-Fleckenstein, I.; Fleckenstein, B.; Chandesris, M. O.; Titeux, M.; Fraitag, S.; Alyanakian, M. A.; Leruez-Ville, M.; Picard, C.; Meyts, I.; Di Santo, J. P.; Hovnanian, A.; Somer, A.; Ozen, A.; Rezaei, N.; Chatila, T. A.; Abel, L.; Leonard, W. J.; Tangye, S. G.; Puel, A.; Casanova, J. L.

Science Immunology 3 (24) 2018 10.1126/sciimmunol.aat4956