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47 items matching your search terms.
Phosphatidylinositol 3-kinase signaling and immune regulation: insights into disease pathogenesis and clinical implications
Nguyen, T.; Deenick, E. K.; Tangye, S. G.
Expert Review of Clinical Immunology 17 (8) :905-914, 2021 10.1080/1744666X.2021.1945443
Genomic Spectrum and Phenotypic Heterogeneity of Human IL-21 Receptor Deficiency
Cagdas, D. Mayr, D. Baris, S. Worley, L. Langley, D. B. Metin, A. Aytekin, E. S. Atan, R. Kasap, N. Bal, S. K. Dmytrus, J. Heredia, R. J. Karasu, G. Torun, S. H. Toyran, M. Karakoc-Aydiner, E. Christ, D. Kuskonmaz, B. Uckan-Cetinkaya, D. Uner, A. Oberndorfer, F. Schiefer, A. I. Uzel, G. Deenick, E. K. Keller, B. Warnatz, K. Neven, B. Durandy, A. Sanal, O. Ma, C. S. Ozen, A. Stepensky, P. Tezcan, I. Boztug, K. Tangye, S. G.
JOURNAL OF CLINICAL IMMUNOLOGY 2021 10.1007/s10875-021-01031-5
B cells: we need them now more than ever.
Deenick, E.K
IMMUNOLOGY AND CELL BIOLOGY 98 (6) :437-438, 2020 https://doi.org/10.1111/imcb.12348
Molecular and cellular mechanisms underlying defective antibody responses.
Deenick, E.K.; Lau, A.; Bier, J.; Kane, A.
IMMUNOLOGY AND CELL BIOLOGY 98 (6) :467-479, 2020 https://doi.org/10.1111/imcb.12345
NK Cells Regulate CD8(+) T Cell Mediated Autoimmunity
Lang, P. A.; Crome, S. Q.; Xu, H. C.; Lang, K. S.; Chapatte, L.; Deenick, E. K.; Grusdat, M.; Pandyra, A. A.; Pozdeev, V. I.; Wang, R.; Holderried, T. A. W.; Cantor, H.; Diefenbach, A.; Elford, A. R.; McIlwain, D. R.; Recher, M.; Haussinger, D.; Mak, T. W.; Ohashi, P. S.
Frontiers in Cellular and Infection Microbiology 10 :36, 2020 10.3389/fcimb.2020.00036
OpenAccess publication Activated PI3Kdelta breaches multiple B cell tolerance checkpoints and causes autoantibody production
Lau, A.; Avery, D. T.; Jackson, K.; Lenthall, H.; Volpi, S.; Brigden, H.; Russell, A. J.; Bier, J.; Reed, J. H.; Smart, J. M.; Cole, T.; Choo, S.; Gray, P. E.; Berglund, L. J.; Hsu, P.; Wong, M.; O'Sullivan, M.; Boztug, K.; Meyts, I.; Uzel, G.; Notarangelo, L. D.; Brink, R.; Goodnow, C. C.; Tangye, S. G.; Deenick, E. K.
JOURNAL OF EXPERIMENTAL MEDICINE 217 (2) :e20191336, 2020 10.1084/jem.20191336
A divergent transcriptional landscape underpins the development and functional branching of MAIT cells
Koay, H. F.; Su, S.; Amann-Zalcenstein, D.; Daley, S. R.; Comerford, I.; Miosge, L.; Whyte, C. E.; Konstantinov, I. E.; d'Udekem, Y.; Baldwin, T.; Hickey, P. F.; Berzins, S. P.; Mak, J. Y. W.; Sontani, Y.; Roots, C. M.; Sidwell, T.; Kallies, A.; Chen, Z.; Nussing, S.; Kedzierska, K.; Mackay, L. K.; McColl, S. R.; Deenick, E. K.; Fairlie, D. P.; McCluskey, J.; Goodnow, C. C.; Ritchie, M. E.; Belz, G. T.; Naik, S. H.; Pellicci, D. G.; Godfrey, D. I.
Science Immunology 4 (41) :eaay6039, 2019 10.1126/sciimmunol.aay6039
Activating mutations in PIK3CD disrupt the differentiation and function of human and murine CD4(+) T cells
Bier, J.; Rao, G.; Payne, K.; Brigden, H.; French, E.; Pelham, S. J.; Lau, A.; Lenthall, H.; Edwards, E. S. J.; Smart, J. M.; Cole, T. S.; Choo, S.; Joshi, A. Y.; Abraham, R. S.; O'Sullivan, M.; Boztug, K.; Meyts, I.; Gray, P. E.; Berglund, L. J.; Hsu, P.; Wong, M.; Holland, S. M.; Notarangelo, L. D.; Uzel, G.; Ma, C. S.; Brink, R.; Tangye, S. G.; Deenick, E. K.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 144 (1) :236-253, 2019 10.1016/j.jaci.2019.01.033
B cell-intrinsic requirement for STK4 in humoral immunity in mice and human subjects
Moran, I.; Avery, D. T.; Payne, K.; Lenthall, H.; Davies, E. G.; Burns, S.; Ip, W.; Oleastro, M. M.; Reisli, I.; Guner, S.; Keles, S.; Notarangelo, L.; Deenick, E. K.; Goodnow, C. C.; Zahra, D.; Brink, R.; Circa; Wong, M.; Tangye, S. G.; Ma, C. S.; Phan, T. G.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 143 (6) :2302-2305, 2019 10.1016/j.jaci.2019.02.010
B cell-intrinsic requirement for STK4 in humoral immunity in mice and humans
Moran, I.; Avery, D. T.; Payne, K.; Lenthall, H.; Davies, E. G.; Burns, S.; Ip, W.; Oleastro, M. M.; Reisli, I.; Guner, S.; Keles, S.; Notarangelo, L.; Deenick, E. K.; Goodnow, C. C.; Zahra, D.; Brink, R.; Circa; Wong, M.; Tangye, S. G.; Ma, C. S.; Phan, T. G.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 143 (6) :2302-2305, 2019 10.1016/j.jaci.2019.02.010
Immune Dysregulation and Disease Pathogenesis due to Activating Mutations in PIK3CD-the Goldilocks' Effect
Tangye, S. G.; Bier, J.; Lau, A.; Nguyen, T.; Uzel, G.; Deenick, E. K.
JOURNAL OF CLINICAL IMMUNOLOGY 39 (2) :148-158, 2019 10.1007/s10875-019-00612-9
Activating PIK3CD mutations impair human cytotoxic lymphocyte differentiation and function and EBV immunity
Edwards, E. S. J.; Bier, J.; Cole, T. S.; Wong, M.; Hsu, P.; Berglund, L. J.; Boztug, K.; Lau, A.; Gostick, E.; Price, D. A.; O'Sullivan, M.; Meyts, I.; Choo, S.; Gray, P.; Holland, S. M.; Deenick, E. K.; Uzel, G.; Tangye, S. G.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 143 (1) :276-291 e6, 2019 10.1016/j.jaci.2018.04.030
Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency
Kong, X. F.; Martinez-Barricarte, R.; Kennedy, J.; Mele, F.; Lazarov, T.; Deenick, E. K.; Ma, C. S.; Breton, G.; Lucero, K. B.; Langlais, D.; Bousfiha, A.; Aytekin, C.; Markle, J.; Trouillet, C.; Jabot-Hanin, F.; Arlehamn, C. S. L.; Rao, G.; Picard, C.; Lasseau, T.; Latorre, D.; Hambleton, S.; Deswarte, C.; Itan, Y.; Abarca, K.; Moraes-Vasconcelos, D.; Ailal, F.; Ikinciogullari, A.; Dogu, F.; Benhsaien, I.; Sette, A.; Abel, L.; Boisson-Dupuis, S.; Schroder, B.; Nussenzweig, M. C.; Liu, K.; Geissmann, F.; Tangye, S. G.; Gros, P.; Sallusto, F.; Bustamante, J.; Casanova, J. L.
NATURE IMMUNOLOGY 19 (9) :973-985, 2018 10.1038/s41590-018-0178-z
Germline-activating mutations in PIK3CD compromise B cell development and function
Avery, D. T.; Kane, A.; Nguyen, T.; Lau, A.; Nguyen, A.; Lenthall, H.; Payne, K.; Shi, W.; Brigden, H.; French, E.; Bier, J.; Hermes, J. R.; Zahra, D.; Sewell, W. A.; Butt, D.; Elliott, M.; Boztug, K.; Meyts, I.; Choo, S.; Hsu, P.; Wong, M.; Berglund, L. J.; Gray, P.; O'Sullivan, M.; Cole, T.; Holland, S. M.; Ma, C. S.; Burkhart, C.; Corcoran, L. M.; Phan, T. G.; Brink, R.; Uzel, G.; Deenick, E. K.; Tangye, S. G.
JOURNAL OF EXPERIMENTAL MEDICINE 215 (8) :2073-2095, 2018 10.1084/jem.20180010
A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity
Beziat, V.; Li, J.; Lin, J. X.; Ma, C. S.; Li, P.; Bousfiha, A.; Pellier, I.; Zoghi, S.; Baris, S.; Keles, S.; Gray, P.; Du, N.; Wang, Y.; Zerbib, Y.; Levy, R.; Leclercq, T.; About, F.; Lim, A. I.; Rao, G.; Payne, K.; Pelham, S. J.; Avery, D. T.; Deenick, E. K.; Pillay, B.; Chou, J.; Guery, R.; Belkadi, A.; Guerin, A.; Migaud, M.; Rattina, V.; Ailal, F.; Benhsaien, I.; Bouaziz, M.; Habib, T.; Chaussabel, D.; Marr, N.; El-Benna, J.; Grimbacher, B.; Wargon, O.; Bustamante, J.; Boisson, B.; Muller-Fleckenstein, I.; Fleckenstein, B.; Chandesris, M. O.; Titeux, M.; Fraitag, S.; Alyanakian, M. A.; Leruez-Ville, M.; Picard, C.; Meyts, I.; Di Santo, J. P.; Hovnanian, A.; Somer, A.; Ozen, A.; Rezaei, N.; Chatila, T. A.; Abel, L.; Leonard, W. J.; Tangye, S. G.; Puel, A.; Casanova, J. L.
Science Immunology 3 (24) 2018 10.1126/sciimmunol.aat4956
Reversible Suppression of Lymphoproliferation and Thrombocytopenia with Rapamycin in a Patient with Common Variable Immunodeficiency
Deenick, E. K.; Morey, A.; Danta, M.; Emmett, L.; Fay, K.; Gracie, G.; Ma, C. S.; Macintosh, R.; Smith, Sabc; Sasson, S. C.; Sewell, W. A.; Cowley, M.; Tangye, S. G.; Kelleher, A. D.; Circa; Phan, T. G.
JOURNAL OF CLINICAL IMMUNOLOGY 38 (2) :159-162, 2018 10.1007/s10875-018-0477-z