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37 items matching your search terms.
Activating mutations in PIK3CD disrupt the differentiation and function of human and murine CD4(+) T cells
Bier, J.; Rao, G.; Payne, K.; Brigden, H.; French, E.; Pelham, S. J.; Lau, A.; Lenthall, H.; Edwards, E. S. J.; Smart, J. M.; Cole, T. S.; Choo, S.; Joshi, A. Y.; Abraham, R. S.; O'Sullivan, M.; Boztug, K.; Meyts, I.; Gray, P. E.; Berglund, L. J.; Hsu, P.; Wong, M.; Holland, S. M.; Notarangelo, L. D.; Uzel, G.; Ma, C. S.; Brink, R.; Tangye, S. G.; Deenick, E. K.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 144 (1) :236-253, 2019 10.1016/j.jaci.2019.01.033
B cell-intrinsic requirement for STK4 in humoral immunity in mice and human subjects
Moran, I.; Avery, D. T.; Payne, K.; Lenthall, H.; Davies, E. G.; Burns, S.; Ip, W.; Oleastro, M. M.; Reisli, I.; Guner, S.; Keles, S.; Notarangelo, L.; Deenick, E. K.; Goodnow, C. C.; Zahra, D.; Brink, R.; Circa; Wong, M.; Tangye, S. G.; Ma, C. S.; Phan, T. G.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 143 (6) :2302-2305, 2019 10.1016/j.jaci.2019.02.010
B cell-intrinsic requirement for STK4 in humoral immunity in mice and humans
Moran, I.; Avery, D. T.; Payne, K.; Lenthall, H.; Davies, E. G.; Burns, S.; Ip, W.; Oleastro, M. M.; Reisli, I.; Guner, S.; Keles, S.; Notarangelo, L.; Deenick, E. K.; Goodnow, C. C.; Zahra, D.; Brink, R.; Circa; Wong, M.; Tangye, S. G.; Ma, C. S.; Phan, T. G.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 143 (6) :2302-2305, 2019 10.1016/j.jaci.2019.02.010
Activating PIK3CD mutations impair human cytotoxic lymphocyte differentiation and function and EBV immunity
Edwards, E. S. J.; Bier, J.; Cole, T. S.; Wong, M.; Hsu, P.; Berglund, L. J.; Boztug, K.; Lau, A.; Gostick, E.; Price, D. A.; O'Sullivan, M.; Meyts, I.; Choo, S.; Gray, P.; Holland, S. M.; Deenick, E. K.; Uzel, G.; Tangye, S. G.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 143 (1) :276-291 e6, 2019 10.1016/j.jaci.2018.04.030
Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency
Kong, X. F.; Martinez-Barricarte, R.; Kennedy, J.; Mele, F.; Lazarov, T.; Deenick, E. K.; Ma, C. S.; Breton, G.; Lucero, K. B.; Langlais, D.; Bousfiha, A.; Aytekin, C.; Markle, J.; Trouillet, C.; Jabot-Hanin, F.; Arlehamn, C. S. L.; Rao, G.; Picard, C.; Lasseau, T.; Latorre, D.; Hambleton, S.; Deswarte, C.; Itan, Y.; Abarca, K.; Moraes-Vasconcelos, D.; Ailal, F.; Ikinciogullari, A.; Dogu, F.; Benhsaien, I.; Sette, A.; Abel, L.; Boisson-Dupuis, S.; Schroder, B.; Nussenzweig, M. C.; Liu, K.; Geissmann, F.; Tangye, S. G.; Gros, P.; Sallusto, F.; Bustamante, J.; Casanova, J. L.
NATURE IMMUNOLOGY 19 (9) :973-985, 2018 10.1038/s41590-018-0178-z
Germline-activating mutations in PIK3CD compromise B cell development and function
Avery, D. T.; Kane, A.; Nguyen, T.; Lau, A.; Nguyen, A.; Lenthall, H.; Payne, K.; Shi, W.; Brigden, H.; French, E.; Bier, J.; Hermes, J. R.; Zahra, D.; Sewell, W. A.; Butt, D.; Elliott, M.; Boztug, K.; Meyts, I.; Choo, S.; Hsu, P.; Wong, M.; Berglund, L. J.; Gray, P.; O'Sullivan, M.; Cole, T.; Holland, S. M.; Ma, C. S.; Burkhart, C.; Corcoran, L. M.; Phan, T. G.; Brink, R.; Uzel, G.; Deenick, E. K.; Tangye, S. G.
JOURNAL OF EXPERIMENTAL MEDICINE 215 (8) :2073-2095, 2018 10.1084/jem.20180010
Reversible Suppression of Lymphoproliferation and Thrombocytopenia with Rapamycin in a Patient with Common Variable Immunodeficiency
Deenick, E. K.; Morey, A.; Danta, M.; Emmett, L.; Fay, K.; Gracie, G.; Ma, C. S.; Macintosh, R.; Smith, Sabc; Sasson, S. C.; Sewell, W. A.; Cowley, M.; Tangye, S. G.; Kelleher, A. D.; Circa; Phan, T. G.
JOURNAL OF CLINICAL IMMUNOLOGY 38 (2) :159-162, 2018 10.1007/s10875-018-0477-z
Cytokine-Mediated Regulation of Human Lymphocyte Development and Function: Insights from Primary Immunodeficiencies
Tangye, S. G.; Pelham, S. J.; Deenick, E. K.; Ma, C. S.
JOURNAL OF IMMUNOLOGY 199 (6) :1949-1958, 2017 10.4049/jimmunol.1700842
The circulating life of a memory T-follicular helper cell
Ma, C. S.; Deenick, E. K.
Clinical & Translational Immunology 6 (5) :e145, 2017 10.1038/cti.2017.26
OpenAccess publication Mutations underlying autosomal dominant hyper-IgE syndrome impair distinct stages of STAT3 signaling
Pelham, S. J.; Lenthall, H.; Deenick, E. K.; Tangye, S. G.
EUROPEAN JOURNAL OF IMMUNOLOGY 46 :139-140, 2016
OpenAccess publication Unique and shared signaling pathways co-operate to regulate the differentiation of human CD4+ T cells into distinct effector subsets.
Ma, C. S.; Wong, N.; Rao, G.; Nguyen, A.; Avery, D. T.; Payne, K.; Torpy, J.; O'Young, P.; Deenick, E.; Bustamante, J.; Puel, A.; Okada, S.; Kobayashi, M.; Martinez-Barricarte, R.; Elliott, M.; Sebnem Kilic, S.; El Baghdadi, J.; Minegishi, Y.; Bousfiha, A.; Robertson, N.; Hambleton, S.; Arkwright, P. D.; French, M.; Blincoe, A. K.; Hsu, P.; Campbell, D. E.; Stormon, M. O.; Wong, M.; Adelstein, S.; Fulcher, D. A.; Cook, M. C.; Stepensky, P.; Boztug, K.; Beier, R.; Ikinciogullari, A.; Ziegler, J.
JOURNAL OF EXPERIMENTAL MEDICINE 213 (8) :1589-603, 2016
Elucidating the effects of disease-causing mutations on STAT3 function in autosomal-dominant hyper-IgE syndrome
Pelham, S. J.; Lenthall, H. C.; Deenick, E. K.; Tangye, S. G.;
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 138 (4) :1210-1213 e5, 2016
OpenAccess publication Monogenic mutations differentially impact the quantity and quality of T follicular helper cells in human primary immunodeficiencies
Ma, C. S.; Wong, N.; Rao, G.; Avery, D. T.; Torpy, J.; Hambridge, T.; Bustamante, J.; Okada, S.; Stoddard, J. L.; Deenick, E. K.; Pelham, S. J.; Payne, K.; Boisson-Dupuis, S.; Puel, A.; Kobayashi, M.; Arkwright, P. D.; Kilic, S. S.; El Baghdadi, J.; Nonoyama, S.; Minegishi, Y.; Mahdaviani, S. A.; Mansouri, D.; Bousfiha, A.; Blincoe, A. K.; French, M. A.; Hsu, P.; Campbell, D. E.; Stormon, M. O.; Wong, M.; Adelstein, S.; Smart, J. M.; Fulcher, D. A.; Cook, M. C.; Phan, T. G.; Stepensky, P.; Boztug, K.; Kansu, A.; Ikinciogullari, A.; Baumann, U.; Beier, R.; Roscioli, T.; Ziegler, J. B.; Gray, P.; Picard, C.; Grimbacher, B.; Warnatz, K.; Holland, S. M.; Casanova, J. L.; Uzel, G.; Tangye, S. G.;
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 136 (4) :993-1006 e1, 2015
OpenAccess publication STAT3 is a critical cell intrinsic regulator of human unconventional T cell numbers and function
Wilson RP, Ives ML, Rao G, Lau A, Payne K, Kobayashi M, Arkwright PD, Peake J, Wong M, Adelstein S, Smart JM, French MA, Fulcher DA, Picard C, Bustamante J, Boisson-Dupuis S, Gray P, Stepensky P, Warnatz K, Freeman AF, Rossjohn J, McCluskey J, Holland SM, Casanova JL, Uze G, Ma C, Tangye SG and Deenick E.
JOURNAL OF EXPERIMENTAL MEDICINE 212 :855-864, 2015
OpenAccess publication T follicular helper cells have distinct modes of migration and molecular signatures in naive and memory immune responses
Suan, D.; Nguyen, A.; Moran, I.; Bourne, K.; Hermes, J. R.; Arshi, M.; Hampton, H. R.; Tomura, M.; Miwa, Y.; Kelleher, A. D.; Kaplan, W.; Deenick, E. K.; Tangye, S. G.; Brink, R.; Chtanova, T.; Phan, T. G.;
IMMUNITY 42 (4) :704-18, 2015