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45 items matching your search terms.
B cells: we need them now more than ever.
Deenick, E.K
IMMUNOLOGY AND CELL BIOLOGY 98 (6) :437-438, 2020 https://doi.org/10.1111/imcb.12348
Molecular and cellular mechanisms underlying defective antibody responses.
Deenick, E.K.; Lau, A.; Bier, J.; Kane, A.
IMMUNOLOGY AND CELL BIOLOGY 98 (6) :467-479, 2020 https://doi.org/10.1111/imcb.12345
NK Cells Regulate CD8(+) T Cell Mediated Autoimmunity
Lang, P. A.; Crome, S. Q.; Xu, H. C.; Lang, K. S.; Chapatte, L.; Deenick, E. K.; Grusdat, M.; Pandyra, A. A.; Pozdeev, V. I.; Wang, R.; Holderried, T. A. W.; Cantor, H.; Diefenbach, A.; Elford, A. R.; McIlwain, D. R.; Recher, M.; Haussinger, D.; Mak, T. W.; Ohashi, P. S.
Frontiers in Cellular and Infection Microbiology 10 :36, 2020 10.3389/fcimb.2020.00036
OpenAccess publication Activated PI3Kdelta breaches multiple B cell tolerance checkpoints and causes autoantibody production
Lau, A.; Avery, D. T.; Jackson, K.; Lenthall, H.; Volpi, S.; Brigden, H.; Russell, A. J.; Bier, J.; Reed, J. H.; Smart, J. M.; Cole, T.; Choo, S.; Gray, P. E.; Berglund, L. J.; Hsu, P.; Wong, M.; O'Sullivan, M.; Boztug, K.; Meyts, I.; Uzel, G.; Notarangelo, L. D.; Brink, R.; Goodnow, C. C.; Tangye, S. G.; Deenick, E. K.
JOURNAL OF EXPERIMENTAL MEDICINE 217 (2) :e20191336, 2020 10.1084/jem.20191336
A divergent transcriptional landscape underpins the development and functional branching of MAIT cells
Koay, H. F.; Su, S.; Amann-Zalcenstein, D.; Daley, S. R.; Comerford, I.; Miosge, L.; Whyte, C. E.; Konstantinov, I. E.; d'Udekem, Y.; Baldwin, T.; Hickey, P. F.; Berzins, S. P.; Mak, J. Y. W.; Sontani, Y.; Roots, C. M.; Sidwell, T.; Kallies, A.; Chen, Z.; Nussing, S.; Kedzierska, K.; Mackay, L. K.; McColl, S. R.; Deenick, E. K.; Fairlie, D. P.; McCluskey, J.; Goodnow, C. C.; Ritchie, M. E.; Belz, G. T.; Naik, S. H.; Pellicci, D. G.; Godfrey, D. I.
Science Immunology 4 (41) :eaay6039, 2019 10.1126/sciimmunol.aay6039
Activating mutations in PIK3CD disrupt the differentiation and function of human and murine CD4(+) T cells
Bier, J.; Rao, G.; Payne, K.; Brigden, H.; French, E.; Pelham, S. J.; Lau, A.; Lenthall, H.; Edwards, E. S. J.; Smart, J. M.; Cole, T. S.; Choo, S.; Joshi, A. Y.; Abraham, R. S.; O'Sullivan, M.; Boztug, K.; Meyts, I.; Gray, P. E.; Berglund, L. J.; Hsu, P.; Wong, M.; Holland, S. M.; Notarangelo, L. D.; Uzel, G.; Ma, C. S.; Brink, R.; Tangye, S. G.; Deenick, E. K.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 144 (1) :236-253, 2019 10.1016/j.jaci.2019.01.033
B cell-intrinsic requirement for STK4 in humoral immunity in mice and human subjects
Moran, I.; Avery, D. T.; Payne, K.; Lenthall, H.; Davies, E. G.; Burns, S.; Ip, W.; Oleastro, M. M.; Reisli, I.; Guner, S.; Keles, S.; Notarangelo, L.; Deenick, E. K.; Goodnow, C. C.; Zahra, D.; Brink, R.; Circa; Wong, M.; Tangye, S. G.; Ma, C. S.; Phan, T. G.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 143 (6) :2302-2305, 2019 10.1016/j.jaci.2019.02.010
B cell-intrinsic requirement for STK4 in humoral immunity in mice and humans
Moran, I.; Avery, D. T.; Payne, K.; Lenthall, H.; Davies, E. G.; Burns, S.; Ip, W.; Oleastro, M. M.; Reisli, I.; Guner, S.; Keles, S.; Notarangelo, L.; Deenick, E. K.; Goodnow, C. C.; Zahra, D.; Brink, R.; Circa; Wong, M.; Tangye, S. G.; Ma, C. S.; Phan, T. G.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 143 (6) :2302-2305, 2019 10.1016/j.jaci.2019.02.010
Immune Dysregulation and Disease Pathogenesis due to Activating Mutations in PIK3CD-the Goldilocks' Effect
Tangye, S. G.; Bier, J.; Lau, A.; Nguyen, T.; Uzel, G.; Deenick, E. K.
JOURNAL OF CLINICAL IMMUNOLOGY 39 (2) :148-158, 2019 10.1007/s10875-019-00612-9
Activating PIK3CD mutations impair human cytotoxic lymphocyte differentiation and function and EBV immunity
Edwards, E. S. J.; Bier, J.; Cole, T. S.; Wong, M.; Hsu, P.; Berglund, L. J.; Boztug, K.; Lau, A.; Gostick, E.; Price, D. A.; O'Sullivan, M.; Meyts, I.; Choo, S.; Gray, P.; Holland, S. M.; Deenick, E. K.; Uzel, G.; Tangye, S. G.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 143 (1) :276-291 e6, 2019 10.1016/j.jaci.2018.04.030
Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency
Kong, X. F.; Martinez-Barricarte, R.; Kennedy, J.; Mele, F.; Lazarov, T.; Deenick, E. K.; Ma, C. S.; Breton, G.; Lucero, K. B.; Langlais, D.; Bousfiha, A.; Aytekin, C.; Markle, J.; Trouillet, C.; Jabot-Hanin, F.; Arlehamn, C. S. L.; Rao, G.; Picard, C.; Lasseau, T.; Latorre, D.; Hambleton, S.; Deswarte, C.; Itan, Y.; Abarca, K.; Moraes-Vasconcelos, D.; Ailal, F.; Ikinciogullari, A.; Dogu, F.; Benhsaien, I.; Sette, A.; Abel, L.; Boisson-Dupuis, S.; Schroder, B.; Nussenzweig, M. C.; Liu, K.; Geissmann, F.; Tangye, S. G.; Gros, P.; Sallusto, F.; Bustamante, J.; Casanova, J. L.
NATURE IMMUNOLOGY 19 (9) :973-985, 2018 10.1038/s41590-018-0178-z
Germline-activating mutations in PIK3CD compromise B cell development and function
Avery, D. T.; Kane, A.; Nguyen, T.; Lau, A.; Nguyen, A.; Lenthall, H.; Payne, K.; Shi, W.; Brigden, H.; French, E.; Bier, J.; Hermes, J. R.; Zahra, D.; Sewell, W. A.; Butt, D.; Elliott, M.; Boztug, K.; Meyts, I.; Choo, S.; Hsu, P.; Wong, M.; Berglund, L. J.; Gray, P.; O'Sullivan, M.; Cole, T.; Holland, S. M.; Ma, C. S.; Burkhart, C.; Corcoran, L. M.; Phan, T. G.; Brink, R.; Uzel, G.; Deenick, E. K.; Tangye, S. G.
JOURNAL OF EXPERIMENTAL MEDICINE 215 (8) :2073-2095, 2018 10.1084/jem.20180010
A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity
Beziat, V.; Li, J.; Lin, J. X.; Ma, C. S.; Li, P.; Bousfiha, A.; Pellier, I.; Zoghi, S.; Baris, S.; Keles, S.; Gray, P.; Du, N.; Wang, Y.; Zerbib, Y.; Levy, R.; Leclercq, T.; About, F.; Lim, A. I.; Rao, G.; Payne, K.; Pelham, S. J.; Avery, D. T.; Deenick, E. K.; Pillay, B.; Chou, J.; Guery, R.; Belkadi, A.; Guerin, A.; Migaud, M.; Rattina, V.; Ailal, F.; Benhsaien, I.; Bouaziz, M.; Habib, T.; Chaussabel, D.; Marr, N.; El-Benna, J.; Grimbacher, B.; Wargon, O.; Bustamante, J.; Boisson, B.; Muller-Fleckenstein, I.; Fleckenstein, B.; Chandesris, M. O.; Titeux, M.; Fraitag, S.; Alyanakian, M. A.; Leruez-Ville, M.; Picard, C.; Meyts, I.; Di Santo, J. P.; Hovnanian, A.; Somer, A.; Ozen, A.; Rezaei, N.; Chatila, T. A.; Abel, L.; Leonard, W. J.; Tangye, S. G.; Puel, A.; Casanova, J. L.
Science Immunology 3 (24) 2018 10.1126/sciimmunol.aat4956
Reversible Suppression of Lymphoproliferation and Thrombocytopenia with Rapamycin in a Patient with Common Variable Immunodeficiency
Deenick, E. K.; Morey, A.; Danta, M.; Emmett, L.; Fay, K.; Gracie, G.; Ma, C. S.; Macintosh, R.; Smith, Sabc; Sasson, S. C.; Sewell, W. A.; Cowley, M.; Tangye, S. G.; Kelleher, A. D.; Circa; Phan, T. G.
JOURNAL OF CLINICAL IMMUNOLOGY 38 (2) :159-162, 2018 10.1007/s10875-018-0477-z
Signal Transducer and Activator of Transcription 3 Control of Human T and B Cell Responses
Deenick, E. K.; Pelham, S. J.; Kane, A.; Ma, C. S.
Frontiers in Immunology 9 :168, 2018 10.3389/fimmu.2018.00168
Cytokine-Mediated Regulation of Human Lymphocyte Development and Function: Insights from Primary Immunodeficiencies
Tangye, S. G.; Pelham, S. J.; Deenick, E. K.; Ma, C. S.
JOURNAL OF IMMUNOLOGY 199 (6) :1949-1958, 2017 10.4049/jimmunol.1700842