Garvan Institute of Medical Research

54 items matching your search terms.

Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens: Burnett, D. L.; Schofield, P.; Langley, D. B.; Jackson, J.; Bourne, K.; Wilson, E.; Porebski, B. T.; Buckle, A. M.; Brink, R.; Goodnow, C. C.; Christ, D.; PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 117 (36) :22341-22350, 2020 10.1073/pnas.2005102117

Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody: Singh, M.; Jackson, K. J. L.; Wang, J. J.; Schofield, P.; Field, M. A.; Koppstein, D.; Peters, T. J.; Burnett, D. L.; Rizzetto, S.; Nevoltris, D.; Masle-Farquhar, E.; Faulks, M. L.; Russell, A.; Gokal, D.; Hanioka, A.; Horikawa, K.; Colella, A. D.; Chataway, T. K.; Blackburn, J.; Mercer, T. R.; Langley, D. B.; Goodall, D. M.; Jefferis, R.; Gangadharan Komala, M.; Kelleher, A. D.; Suan, D.; Rischmueller, M.; Christ, D.; Brink, R.; Luciani, F.; Gordon, T. P.; Goodnow, C. C.; Reed, J. H.; CELL 180 (5) :878-894 e19, 2020 10.1016/j.cell.2020.01.029

Activated PI3Kdelta breaches multiple B cell tolerance checkpoints and causes autoantibody production: Lau, A.; Avery, D. T.; Jackson, K.; Lenthall, H.; Volpi, S.; Brigden, H.; Russell, A. J.; Bier, J.; Reed, J. H.; Smart, J. M.; Cole, T.; Choo, S.; Gray, P. E.; Berglund, L. J.; Hsu, P.; Wong, M.; O'Sullivan, M.; Boztug, K.; Meyts, I.; Uzel, G.; Notarangelo, L. D.; Brink, R.; Goodnow, C. C.; Tangye, S. G.; Deenick, E. K.; JOURNAL OF EXPERIMENTAL MEDICINE 217 (2) :e20191336, 2020 10.1084/jem.20191336

Deletion of self-reactive CCR7- thymocytes in the absence of MHC expression on thymic epithelial cells: Wirasinha, R. C.; Chan, A.; Yap, J. Y.; Hu, D. Y.; Teh, C. E.; Gray, D. H. D.; Goodnow, C. C.; Daley, S. R.; CELL DEATH AND DIFFERENTIATION 26 (12) :2727-2739, 2019 10.1038/s41418-019-0331-8

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells: Koay, H. F.; Su, S.; Amann-Zalcenstein, D.; Daley, S. R.; Comerford, I.; Miosge, L.; Whyte, C. E.; Konstantinov, I. E.; d'Udekem, Y.; Baldwin, T.; Hickey, P. F.; Berzins, S. P.; Mak, J. Y. W.; Sontani, Y.; Roots, C. M.; Sidwell, T.; Kallies, A.; Chen, Z.; Nussing, S.; Kedzierska, K.; Mackay, L. K.; McColl, S. R.; Deenick, E. K.; Fairlie, D. P.; McCluskey, J.; Goodnow, C. C.; Ritchie, M. E.; Belz, G. T.; Naik, S. H.; Pellicci, D. G.; Godfrey, D. I.; Science Immunology 4 (41) :eaay6039, 2019 10.1126/sciimmunol.aay6039

CARD11 is dispensable for homeostatic responses and suppressive activity of peripherally induced FOXP3(+) regulatory T cells: Policheni, A.; Horikawa, K.; Milla, L.; Kofler, J.; Bouillet, P.; Belz, G. T.; O'Reilly, L. A.; Goodnow, C. C.; Strasser, A.; Gray, D. H.; IMMUNOLOGY AND CELL BIOLOGY 97 (8) :740-752, 2019 10.1111/imcb.12268

Clonal redemption and clonal anergy as mechanisms to balance B cell tolerance and immunity: Burnett, D. L.; Reed, J. H.; Christ, D.; Goodnow, C. C.; IMMUNOLOGICAL REVIEWS 292 (1) :61-75, 2019 10.1111/imr.12808

Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity: Zammit, N. W.; Siggs, O. M.; Gray, P. E.; Horikawa, K.; Langley, D. B.; Walters, S. N.; Daley, S. R.; Loetsch, C.; Warren, J.; Yap, J. Y.; Cultrone, D.; Russell, A.; Malle, E. K.; Villanueva, J. E.; Cowley, M. J.; Gayevskiy, V.; Dinger, M. E.; Brink, R.; Zahra, D.; Chaudhri, G.; Karupiah, G.; Whittle, B.; Roots, C.; Bertram, E.; Yamada, M.; Jeelall, Y.; Enders, A.; Clifton, B. E.; Mabbitt, P. D.; Jackson, C. J.; Watson, S. R.; Jenne, C. N.; Lanier, L. L.; Wiltshire, T.; Spitzer, M. H.; Nolan, G. P.; Schmitz, F.; Aderem, A.; Porebski, B. T.; Buckle, A. M.; Abbott, D. W.; Ziegler, J. B.; Craig, M. E.; Benitez-Aguirre, P.; Teo, J.; Tangye, S. G.; King, C.; Wong, M.; Cox, M. P.; Phung, W.; Tang, J.; Sandoval, W.; Wertz, I. E.; Christ, D.; Goodnow, C. C.; Grey, S. T.; NATURE IMMUNOLOGY 20 (10) :1299-1310, 2019 10.1038/s41590-019-0492-0

Preponderance of CTLA4 Variation Associated With Autosomal Dominant Immune Dysregulation in the MYPPPY Motif: Siggs, O. M.; Russell, A.; Singh-Grewal, D.; Wong, M.; Chan, P.; Craig, M. E.; O'Loughlin, T.; Stormon, M.; Goodnow, C. C.; Frontiers in Immunology 10 :1544, 2019 10.3389/fimmu.2019.01544

High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes: Singh, M.; Al-Eryani, G.; Carswell, S.; Ferguson, J. M.; Blackburn, J.; Barton, K.; Roden, D.; Luciani, F.; Giang Phan, T.; Junankar, S.; Jackson, K.; Goodnow, C. C.; Smith, M. A.; Swarbrick, A.; Nature Communications 10 (1) :3120, 2019 10.1038/s41467-019-11049-4

B cell-intrinsic requirement for STK4 in humoral immunity in mice and human subjects: Moran, I.; Avery, D. T.; Payne, K.; Lenthall, H.; Davies, E. G.; Burns, S.; Ip, W.; Oleastro, M. M.; Reisli, I.; Guner, S.; Keles, S.; Notarangelo, L.; Deenick, E. K.; Goodnow, C. C.; Zahra, D.; Brink, R.; Circa; Wong, M.; Tangye, S. G.; Ma, C. S.; Phan, T. G.; JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 143 (6) :2302-2305, 2019 10.1016/j.jaci.2019.02.010

B cell-intrinsic requirement for STK4 in humoral immunity in mice and humans: Moran, I.; Avery, D. T.; Payne, K.; Lenthall, H.; Davies, E. G.; Burns, S.; Ip, W.; Oleastro, M. M.; Reisli, I.; Guner, S.; Keles, S.; Notarangelo, L.; Deenick, E. K.; Goodnow, C. C.; Zahra, D.; Brink, R.; Circa; Wong, M.; Tangye, S. G.; Ma, C. S.; Phan, T. G.; JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 143 (6) :2302-2305, 2019 10.1016/j.jaci.2019.02.010

IRF2 Transcriptionally Induces GSDMD Expression for Pyroptosis: Kayagaki, N.; Lee, B. L.; Stowe, I. B.; Kornfeld, O. S.; O'Rourke, K.; Mirrashidi, K. M.; Haley, B.; Watanabe, C.; Roose-Girma, M.; Modrusan, Z.; Kummerfeld, S.; Reja, R.; Zhang, Y.; Cho, V.; Andrews, T. D.; Morris, L. X.; Goodnow, C. C.; Bertram, E. M.; Dixit, V. M.; Science Signaling 12 (582) :eaax4917, 2019 10.1126/scisignal.aax4917

DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns: Skvortsova, K.; Masle-Farquhar, E.; Luu, P. L.; Song, J. Z.; Qu, W.; Zotenko, E.; Gould, C. M.; Du, Q.; Peters, T. J.; Colino-Sanguino, Y.; Pidsley, R.; Nair, S. S.; Khoury, A.; Smith, G. C.; Miosge, L. A.; Reed, J. H.; Kench, J. G.; Rubin, M. A.; Horvath, L.; Bogdanovic, O.; Lim, S. M.; Polo, J. M.; Goodnow, C. C.; Stirzaker, C.; Clark, S. J.; CANCER CELL 35 (2) :297-314 e8, 2019 10.1016/j.ccell.2019.01.004