Publications

68 items matching your search terms.

Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability

Burnett, D. L.; Jackson, K. J. L.; Langley, D. B.; Aggrawal, A.; Stella, A. O.; Johansen, M. D.; Balachandran, H.; Lenthall, H.; Rouet, R.; Walker, G.; Saunders, B. M.; Singh, M.; Li, H.; Henry, J. Y.; Jackson, J.; Stewart, A. G.; Witthauer, F.; Spence, M. A.; Hansbro, N. G.; Jackson, C.; Schofield, P.; Milthorpe, C.; Martinello, M.; Schulz, S. R.; Roth, E.; Kelleher, A.; Emery, S.; Britton, W. J.; Rawlinson, W. D.; Karl, R.; Schafer, S.; Winkler, T. H.; Brink, R.; Bull, R. A.; Hansbro, P. M.; Jack, H. M.; Turville, S.; Christ, D.; Goodnow, C. C.

IMMUNITY 54 (12) :2908-2921 e6, 2021 10.1016/j.immuni.2021.10.019

Calling differentially methylated regions from whole genome bisulphite sequencing with DMRcate

Peters, T. J.; Buckley, M. J.; Chen, Y.; Smyth, G. K.; Goodnow, C. C.; Clark, S. J.

NUCLEIC ACIDS RESEARCH 49 (19) :e109, 2021 10.1093/nar/gkab637

Human transitional and IgM(low) mature naive B cells preserve permissive B-cell receptors

Zhang, Z., Jara, C. J., Singh, M., Xu, H., Goodnow, C. C., Jackson, K. J.,Reed, J. H.

IMMUNOLOGY AND CELL BIOLOGY 2021 10.1111/imcb.12478

SAMD9L autoinflammatory or ataxia pancytopenia disease mutations activate cell-autonomous translational repression

Russell, A. J.; Gray, P. E.; Ziegler, J. B.; Kim, Y. J.; Smith, S.; Sewell, W. A.; Goodnow, C. C.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 118 (34) 2021 10.1073/pnas.2110190118

Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies

Rouet, R.; Mazigi, O.; Walker, G. J.; Langley, D. B.; Sobti, M.; Schofield, P.; Lenthall, H.; Jackson, J.; Ubiparipovic, S.; Henry, J. Y.; Abayasingam, A.; Burnett, D.; Kelleher, A.; Brink, R.; Bull, R. A.; Turville, S.; Stewart, A. G.; Goodnow, C. C.; Rawlinson, W. D.; Christ, D.

mAbs 13 (1) :1922134, 2021 10.1080/19420862.2021.1922134

Antigen-driven EGR2 expression is required for exhausted CD8(+) T cell stability and maintenance

Wagle, M. V.; Vervoort, S. J.; Kelly, M. J.; Van Der Byl, W.; Peters, T. J.; Martin, B. P.; Martelotto, L. G.; Nussing, S.; Ramsbottom, K. M.; Torpy, J. R.; Knight, D.; Reading, S.; Thia, K.; Miosge, L. A.; Howard, D. R.; Gloury, R.; Gabriel, S. S.; Utzschneider, D. T.; Oliaro, J.; Powell, J. D.; Luciani, F.; Trapani, J. A.; Johnstone, R. W.; Kallies, A.; Goodnow, C. C.; Parish, I. A.

Nature Communications 12 (1) :2782, 2021 10.1038/s41467-021-23044-9

Loss of hnRNPLL-dependent splicing of Ptprc has no impact on B-cell development, activation and terminal differentiation into antibody-secreting cells

Yabas, M.; Yazicioglu, Y. F.; Hoyne, G. F.; Goodnow, C. C.; Enders, A.

IMMUNOLOGY AND CELL BIOLOGY 99 (5) :532-541, 2021 10.1111/imcb.12433

A Point Mutation in IKAROS ZF1 Causes a B Cell Deficiency in Mice

Boast, B.; Miosge, L. A.; Kuehn, H. S.; Cho, V.; Athanasopoulos, V.; McNamara, H. A.; Sontani, Y.; Mei, Y.; Howard, D.; Sutton, H. J.; Omari, S. A.; Yu, Z.; Nasreen, M.; Andrews, T. D.; Cockburn, I. A.; Goodnow, C. C.; Rosenzweig, S. D.; Enders, A.

JOURNAL OF IMMUNOLOGY 206 (7) :1505-1514, 2021 10.4049/jimmunol.1901464

Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice

Masle-Farquhar, E.; Russell, A.; Li, Y.; Zhu, F.; Rui, L.; Brink, R.; Goodnow, C. C.

PLoS One 16 (4) :e0237830, 2021 10.1371/journal.pone.0237830

NINJ1 mediates plasma membrane rupture during lytic cell death

Kayagaki, N.; Kornfeld, O. S.; Lee, B. L.; Stowe, I. B.; O'Rourke, K.; Li, Q.; Sandoval, W.; Yan, D.; Kang, J.; Xu, M.; Zhang, J.; Lee, W. P.; McKenzie, B. S.; Ulas, G.; Payandeh, J.; Roose-Girma, M.; Modrusan, Z.; Reja, R.; Sagolla, M.; Webster, J. D.; Cho, V.; Andrews, T. D.; Morris, L. X.; Miosge, L. A.; Goodnow, C. C.; Bertram, E. M.; Dixit, V. M.

NATURE 591 (7848) :131-136, 2021 10.1038/s41586-021-03218-7

COVID-19, varying genetic resistance to viral disease and immune tolerance checkpoints

Goodnow, C. C.

IMMUNOLOGY AND CELL BIOLOGY 99 (2) :177-191, 2021 10.1111/imcb.12419

Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility

Wirasinha, R. C.; Davies, A. R.; Srivastava, M.; Sheridan, J. M.; Sng, X. Y. X.; Delmonte, O. M.; Dobbs, K.; Loh, K. L.; Miosge, L. A.; Lee, C. E.; Chand, R.; Chan, A.; Yap, J. Y.; Keller, M. D.; Chen, K.; Rossjohn, J.; La Gruta, N. L.; Vinuesa, C. G.; Reid, H. H.; Lionakis, M. S.; Notarangelo, L. D.; Gray, D. H. D.; Goodnow, C. C.; Cook, M. C.; Daley, S. R.

JOURNAL OF EXPERIMENTAL MEDICINE 218 (2) :e20200476, 2021 10.1084/jem.20200476

DOCK8 deficiency diminishes thymic T-regulatory cell development but not thymic deletion

Randall, K. L.; Law, H. D.; Ziolkowski, A. F.; Wirasinha, R. C.; Goodnow, C. C.; Daley, S. R.

Clinical & Translational Immunology 10 (1) :e1236, 2021 10.1002/cti2.1236

Loss of hnRNPLL-dependent splicing of Ptprc has no impact on B-cell development, activation and terminal differentiation into antibody-secreting cells

Yabas, M.; Yazicioglu, Y. F.; Hoyne, G. F.; Goodnow, C. C.; Enders, A.

IMMUNOLOGY AND CELL BIOLOGY 2020 10.1111/imcb.12433

Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens

Burnett, D. L.; Schofield, P.; Langley, D. B.; Jackson, J.; Bourne, K.; Wilson, E.; Porebski, B. T.; Buckle, A. M.; Brink, R.; Goodnow, C. C.; Christ, D.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 117 (36) :22341-22350, 2020 10.1073/pnas.2005102117

Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody

Singh, M.; Jackson, K. J. L.; Wang, J. J.; Schofield, P.; Field, M. A.; Koppstein, D.; Peters, T. J.; Burnett, D. L.; Rizzetto, S.; Nevoltris, D.; Masle-Farquhar, E.; Faulks, M. L.; Russell, A.; Gokal, D.; Hanioka, A.; Horikawa, K.; Colella, A. D.; Chataway, T. K.; Blackburn, J.; Mercer, T. R.; Langley, D. B.; Goodall, D. M.; Jefferis, R.; Gangadharan Komala, M.; Kelleher, A. D.; Suan, D.; Rischmueller, M.; Christ, D.; Brink, R.; Luciani, F.; Gordon, T. P.; Goodnow, C. C.; Reed, J. H.

CELL 180 (5) :878-894 e19, 2020 10.1016/j.cell.2020.01.029