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28 items matching your search terms.
Quantifying and visualising the nuances of cellular dynamics in vivo using intravital imaging
Murphy, K. J.; Reed, D. A.; Trpceski, M.; Herrmann, D.; Timpson, P.
CURRENT OPINION IN CELL BIOLOGY 72 :41-53, 2021 10.1016/j.ceb.2021.04.007
Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status
Murphy, K. J.; Reed, D. A.; Vennin, C.; Conway, J. R. W.; Nobis, M.; Yin, J. X.; Chambers, C. R.; Pereira, B. A.; Lee, V.; Filipe, E. C.; Trpceski, M.; Ritchie, S.; Lucas, M. C.; Warren, S. C.; Skhinas, J. N.; Magenau, A.; Metcalf, X. L.; Stoehr, J.; Major, G.; Parkin, A.; Bidanel, R.; Lyons, R. J.; Zaratzian, A.; Tayao, M.; Da Silva, A.; Abdulkhalek, L.; Australian Pancreatic Genome, Initiative; Australian Pancreatic Cancer Matrix, Atlas; Gill, A. J.; Johns, A. L.; Biankin, A. V.; Samra, J.; Grimmond, S. M.; Chou, A.; Goetz, J. G.; Samuel, M. S.; Lyons, J. G.; Burgess, A.; Caldon, C. E.; Horvath, L. G.; Daly, R. J.; Gadegaard, N.; Wang, Y.; Sansom, O. J.; Morton, J. P.; Cox, T. R.; Pajic, M.; Herrmann, D.; Timpson, P.
Science Advances 7 (40) :eabh0363, 2021 10.1126/sciadv.abh0363
Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging
Floerchinger, A.; Murphy, K. J.; Latham, S. L.; Warren, S. C.; McCulloch, A. T.; Lee, Y. K.; Stoehr, J.; Melenec, P.; Guaman, C. S.; Metcalf, X. L.; Lee, V.; Zaratzian, A.; Da Silva, A.; Tayao, M.; Rolo, S.; Phimmachanh, M.; Sultani, G.; McDonald, L.; Mason, S. M.; Ferrari, N.; Ooms, L. M.; Johnsson, A. E.; Spence, H. J.; Olson, M. F.; Machesky, L. M.; Sansom, O. J.; Morton, J. P.; Mitchell, C. A.; Samuel, M. S.; Croucher, D. R.; Welch, H. C. E.; Blyth, K.; Caldon, C. E.; Herrmann, D.; Anderson, K. I.; Timpson, P.; Nobis, M.
Cell Reports 36 (11) :109689, 2021 10.1016/j.celrep.2021.109689
Dynamic Stromal Alterations Influence Tumor-Stroma Crosstalk to Promote Pancreatic Cancer and Treatment Resistance
Murphy, K. J.; Chambers, C. R.; Herrmann, D.; Timpson, P.; Pereira, B. A.
Cancers 13 (14) 2021 10.3390/cancers13143481
Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis
Samuel, M.; Fonseka, P.; Sanwlani, R.; Gangoda, L.; Chee, S. H.; Keerthikumar, S.; Spurling, A.; Chitti, S. V.; Zanker, D.; Ang, C. S.; Atukorala, I.; Kang, T.; Shahi, S.; Marzan, A. L.; Nedeva, C.; Vennin, C.; Lucas, M. C.; Cheng, L.; Herrmann, D.; Pathan, M.; Chisanga, D.; Warren, S. C.; Zhao, K.; Abraham, N.; Anand, S.; Boukouris, S.; Adda, C. G.; Jiang, L.; Shekhar, T. M.; Baschuk, N.; Hawkins, C. J.; Johnston, A. J.; Orian, J. M.; Hoogenraad, N. J.; Poon, I. K.; Hill, A. F.; Jois, M.; Timpson, P.; Parker, B. S.; Mathivanan, S.
Nature Communications 12 (1) :3950, 2021 10.1038/s41467-021-24273-8
Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse
Nobis, M.; Herrmann, D.; Warren, S. C.; Strathdee, D.; Cox, T. R.; Anderson, K. I.; Timpson, P.
Small GTPases 11 (4) :240-247, 2020 10.1080/21541248.2018.1438024
OpenAccess publication Inhibition of PAK1 suppresses pancreatic cancer by stimulation of anti-tumour immunity through down-regulation of PD-L1
Wang, K.; Zhan, Y.; Huynh, N.; Dumesny, C.; Wang, X.; Asadi, K.; Herrmann, D.; Timpson, P.; Yang, Y.; Walsh, K.; Baldwin, G. S.; Nikfarjam, M.; He, H.
CANCER LETTERS 472 :8-18, 2020 10.1016/j.canlet.2019.12.020
OpenAccess publication Fluids and their mechanics in tumour transit: shaping metastasis
Follain, G.; Herrmann, D.; Harlepp, S.; Hyenne, V.; Osmani, N.; Warren, S. C.; Timpson, P.; Goetz, J. G.
NATURE REVIEWS CANCER 20 (2) :107-124, 2020 10.1038/s41568-019-0221-x
CAF subpopulations: A new reservoir of stromal targets in pancreatic cancer
Pereira, B. A.; Vennin, C.; Papanicolaou, M.; Chambers, C. R.; Herrmann, D.; Morton, J. P.; Cox, T. R.; Timpson, P.
Trends in Cancer 5 (11) :724-741, 2019 10.1016/j.trecan.2019.09.010
OpenAccess publication CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan
Vennin, C.; Melenec, P.; Rouet, R.; Nobis, M.; Cazet, A. S.; Murphy, K. J.; Herrmann, D.; Reed, D. A.; Lucas, M. C.; Warren, S. C.; Elgundi, Z.; Pinese, M.; Kalna, G.; Roden, D.; Samuel, M.; Zaratzian, A.; Grey, S. T.; Da Silva, A.; Leung, W.; Mathivanan, S.; Wang, Y.; Braithwaite, A. W.; Christ, D.; Benda, A.; Parkin, A.; Phillips, P. A.; Whitelock, J. M.; Gill, A. J.; Sansom, O. J.; Croucher, D. R.; Parker, B. L.; Pajic, M.; Morton, J. P.; Cox, T. R.; Timpson, P.
Nature Communications 10 (1) :3637, 2019 10.1038/s41467-019-10968-6
Combating pancreatic cancer with PI3K pathway inhibitors in the era of personalised medicine
Conway, J. R.; Herrmann, D.; Evans, T. J.; Morton, J. P.; Timpson, P.
GUT 68 (4) :742-758, 2019 10.1136/gutjnl-2018-316822
OpenAccess publication ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-beta signalling
Pinho, A. V.; Van Bulck, M.; Chantrill, L.; Arshi, M.; Sklyarova, T.; Herrmann, D.; Vennin, C.; Gallego-Ortega, D.; Mawson, A.; Giry-Laterriere, M.; Magenau, A.; Leuckx, G.; Baeyens, L.; Gill, A. J.; Phillips, P.; Timpson, P.; Biankin, A. V.; Wu, J.; Rooman, I.
Nature Communications 9 (1) :5083, 2018 10.1038/s41467-018-07497-z
Recent advances in understanding the complexities of metastasis
Chitty, J. L.; Filipe, E. C.; Lucas, M. C.; Herrmann, D.; Cox, T. R.; Timpson, P.
Methods in Molecular Biology 7 2018 10.12688/f1000research.15064.2
OpenAccess publication Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer
Cazet, A. S.; Hui, M. N.; Elsworth, B. L.; Wu, S. Z.; Roden, D.; Chan, C. L.; Skhinas, J. N.; Collot, R.; Yang, J.; Harvey, K.; Johan, M. Z.; Cooper, C.; Nair, R.; Herrmann, D.; McFarland, A.; Deng, N.; Ruiz-Borrego, M.; Rojo, F.; Trigo, J. M.; Bezares, S.; Caballero, R.; Lim, E.; Timpson, P.; O'Toole, S.; Watkins, D. N.; Cox, T. R.; Samuel, M. S.; Martin, M.; Swarbrick, A.
Nature Communications 9 (1) :2897, 2018 10.1038/s41467-018-05220-6
OpenAccess publication Removing physiological motion from intravital and clinical functional imaging data
Warren, S. C.; Nobis, M.; Magenau, A.; Mohammed, Y. H.; Herrmann, D.; Moran, I.; Vennin, C.; Conway, J. R.; Melenec, P.; Cox, T. R.; Wang, Y.; Morton, J. P.; Welch, H. C.; Strathdee, D.; Anderson, K. I.; Phan, T. G.; Roberts, M. S.; Timpson, P.
eLife 7 :e35800, 2018 10.7554/eLife.35800
OpenAccess publication Intravital imaging to monitor therapeutic response in moving hypoxic regions resistant to PI3K pathway targeting in pancreatic cancer
Conway, J. R. W.; Warren, S. C.; Herrmann, D.; Murphy, K. J.; Cazet, A. S.; Vennin, C.; Shearer, R. F.; Killen, M. J.; Magenau, A.; Melenec, P.; Pinese, M.; Nobis, M.; Zaratzian, A.; Boulghourjian, A.; Da Silva, A. M.; Del Monte-Nieto, G.; Adam, A. S. A.; Harvey, R. P.; Haigh, J. J.; Wang, Y.; Croucher, D. R.; Sansom, O. J.; Pajic, M.; Caldon, C. E.; Morton, J. P.; Timpson, P.
Cell Reports 23 (11) :3312-3326, 2018 10.1016/j.celrep.2018.05.038