Publications

24 items matching your search terms.

Genetic and structural basis of the human anti-alpha-galactosyl antibody response

Langley, D. B.; Schofield, P.; Nevoltris, D.; Jackson, J.; Jackson, K. J. L.; Peters, T. J.; Burk, M.; Matthews, J. M.; Basten, A.; Goodnow, C. C.; van Nunen, S.; Reed, J. H.; Christ, D.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 119 (28) :e2123212119, 2022 10.1073/pnas.2123212119

Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability

Burnett, D. L.; Jackson, K. J. L.; Langley, D. B.; Aggrawal, A.; Stella, A. O.; Johansen, M. D.; Balachandran, H.; Lenthall, H.; Rouet, R.; Walker, G.; Saunders, B. M.; Singh, M.; Li, H.; Henry, J. Y.; Jackson, J.; Stewart, A. G.; Witthauer, F.; Spence, M. A.; Hansbro, N. G.; Jackson, C.; Schofield, P.; Milthorpe, C.; Martinello, M.; Schulz, S. R.; Roth, E.; Kelleher, A.; Emery, S.; Britton, W. J.; Rawlinson, W. D.; Karl, R.; Schafer, S.; Winkler, T. H.; Brink, R.; Bull, R. A.; Hansbro, P. M.; Jack, H. M.; Turville, S.; Christ, D.; Goodnow, C. C.

IMMUNITY 54 (12) :2908-2921 e6, 2021 10.1016/j.immuni.2021.10.019

Surface-associated antigen induces permeabilization of primary mouse B-cells and lysosome exocytosis facilitating antigen uptake and presentation to T-cells

Maeda, F. Y.; van Haaren, J. J.; Langley, D. B.; Christ, D.; Andrews, N. W.; Song, W.

eLife 10 :e66984, 2021 10.7554/eLife.66984

Genomic Spectrum and Phenotypic Heterogeneity of Human IL-21 Receptor Deficiency

Cagdas, D. Mayr, D. Baris, S. Worley, L. Langley, D. B. Metin, A. Aytekin, E. S. Atan, R. Kasap, N. Bal, S. K. Dmytrus, J. Heredia, R. J. Karasu, G. Torun, S. H. Toyran, M. Karakoc-Aydiner, E. Christ, D. Kuskonmaz, B. Uckan-Cetinkaya, D. Uner, A. Oberndorfer, F. Schiefer, A. I. Uzel, G. Deenick, E. K. Keller, B. Warnatz, K. Neven, B. Durandy, A. Sanal, O. Ma, C. S. Ozen, A. Stepensky, P. Tezcan, I. Boztug, K. Tangye, S. G.

JOURNAL OF CLINICAL IMMUNOLOGY 2021 10.1007/s10875-021-01031-5

Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies

Rouet, R.; Mazigi, O.; Walker, G. J.; Langley, D. B.; Sobti, M.; Schofield, P.; Lenthall, H.; Jackson, J.; Ubiparipovic, S.; Henry, J. Y.; Abayasingam, A.; Burnett, D.; Kelleher, A.; Brink, R.; Bull, R. A.; Turville, S.; Stewart, A. G.; Goodnow, C. C.; Rawlinson, W. D.; Christ, D.

mAbs 13 (1) :1922134, 2021 10.1080/19420862.2021.1922134

Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens

Burnett, D. L.; Schofield, P.; Langley, D. B.; Jackson, J.; Bourne, K.; Wilson, E.; Porebski, B. T.; Buckle, A. M.; Brink, R.; Goodnow, C. C.; Christ, D.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 117 (36) :22341-22350, 2020 10.1073/pnas.2005102117

Systematic functional identification of cancer multi-drug resistance genes

Lau MT., Ghazanfar S., Parkin A., Chou A., Rouaen JR., Littleboy JB., Nessem D., Khuong TM., Nevoltris D., Schofield P., Langley D., Christ D., Yang J., Pajic M., Neely GG.

GENOME BIOLOGY 21 (1) :27, 2020 https://doi.org/10.1186/s13059-020-1940-8

Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody

Singh, M.; Jackson, K. J. L.; Wang, J. J.; Schofield, P.; Field, M. A.; Koppstein, D.; Peters, T. J.; Burnett, D. L.; Rizzetto, S.; Nevoltris, D.; Masle-Farquhar, E.; Faulks, M. L.; Russell, A.; Gokal, D.; Hanioka, A.; Horikawa, K.; Colella, A. D.; Chataway, T. K.; Blackburn, J.; Mercer, T. R.; Langley, D. B.; Goodall, D. M.; Jefferis, R.; Gangadharan Komala, M.; Kelleher, A. D.; Suan, D.; Rischmueller, M.; Christ, D.; Brink, R.; Luciani, F.; Gordon, T. P.; Goodnow, C. C.; Reed, J. H.

CELL 180 (5) :878-894 e19, 2020 10.1016/j.cell.2020.01.029

Protein A superantigen: structure, engineering and molecular basis of antibody recognition

Mazigi, O.; Schofield, P.; Langley, D. B.; Christ, D.

Protein Eng 32 (8) :359-366, 2019 10.1093/protein/gzz026

Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity

Zammit, N. W.; Siggs, O. M.; Gray, P. E.; Horikawa, K.; Langley, D. B.; Walters, S. N.; Daley, S. R.; Loetsch, C.; Warren, J.; Yap, J. Y.; Cultrone, D.; Russell, A.; Malle, E. K.; Villanueva, J. E.; Cowley, M. J.; Gayevskiy, V.; Dinger, M. E.; Brink, R.; Zahra, D.; Chaudhri, G.; Karupiah, G.; Whittle, B.; Roots, C.; Bertram, E.; Yamada, M.; Jeelall, Y.; Enders, A.; Clifton, B. E.; Mabbitt, P. D.; Jackson, C. J.; Watson, S. R.; Jenne, C. N.; Lanier, L. L.; Wiltshire, T.; Spitzer, M. H.; Nolan, G. P.; Schmitz, F.; Aderem, A.; Porebski, B. T.; Buckle, A. M.; Abbott, D. W.; Ziegler, J. B.; Craig, M. E.; Benitez-Aguirre, P.; Teo, J.; Tangye, S. G.; King, C.; Wong, M.; Cox, M. P.; Phung, W.; Tang, J.; Sandoval, W.; Wertz, I. E.; Christ, D.; Goodnow, C. C.; Grey, S. T.

NATURE IMMUNOLOGY 20 (10) :1299-1310, 2019 10.1038/s41590-019-0492-0

Human Antibody Bispecifics through Phage Display Selection

Luthra, A.; Langley, D. B.; Schofield, P.; Jackson, J.; Abdelatti, M.; Rouet, R.; Nevoltris, D.; Mazigi, O.; Crossett, B.; Christie, M.; Christ, D.

Biochemistry 58 (13) :1701-1704, 2019 10.1021/acs.biochem.9b00037

Crystal structure of duck egg lysozyme isoform II (DEL-II)

Langley, D. B.; Christ, D.

BMC STRUCTURAL BIOLOGY 18 (1) :10, 2018 10.1186/s12900-018-0090-7

I-motif DNA structures are formed in the nuclei of human cells

Zeraati, M.; Langley, D. B.; Schofield, P.; Moye, A. L.; Rouet, R.; Hughes, W. E.; Bryan, T. M.; Dinger, M. E.; Christ, D.

Nature Chemistry 10 (6) :631-637, 2018 10.1038/s41557-018-0046-3

Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination

Burnett, D. L.; Langley, D. B.; Schofield, P.; Hermes, J. R.; Chan, T. D.; Jackson, J.; Bourne, K.; Reed, J. H.; Patterson, K.; Porebski, B. T.; Brink, R.; Christ, D.; Goodnow, C. C.

SCIENCE 360 (6385) :223-226, 2018 10.1126/science.aao3859

Next-Generation Sequencing of Antibody Display Repertoires

Rouet, R.; Jackson, K. J. L.; Langley, D. B.; Christ, D.

Frontiers in Immunology 9 :118, 2018 10.3389/fimmu.2018.00118

Structural basis of antigen recognition: crystal structure of duck egg lysozyme

Langley, D. B.; Crossett, B.; Schofield, P.; Jackson, J.; Zeraati, M.; Maltby, D.; Christie, M.; Burnett, D.; Brink, R.; Goodnow, C.; Christ, D.

Acta Crystallographica Section D-Structural Biology 73 (Pt 11) :910-920, 2017 10.1107/S2059798317013730