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20 items matching your search terms.
Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies
Rouet, R.; Mazigi, O.; Walker, G. J.; Langley, D. B.; Sobti, M.; Schofield, P.; Lenthall, H.; Jackson, J.; Ubiparipovic, S.; Henry, J. Y.; Abayasingam, A.; Burnett, D.; Kelleher, A.; Brink, R.; Bull, R. A.; Turville, S.; Stewart, A. G.; Goodnow, C. C.; Rawlinson, W. D.; Christ, D.
mAbs 13 (1) :1922134, 2021 10.1080/19420862.2021.1922134
Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens
Burnett, D. L.; Schofield, P.; Langley, D. B.; Jackson, J.; Bourne, K.; Wilson, E.; Porebski, B. T.; Buckle, A. M.; Brink, R.; Goodnow, C. C.; Christ, D.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 117 (36) :22341-22350, 2020 10.1073/pnas.2005102117
OpenAccess publication Systematic functional identification of cancer multi-drug resistance genes
Lau MT., Ghazanfar S., Parkin A., Chou A., Rouaen JR., Littleboy JB., Nessem D., Khuong TM., Nevoltris D., Schofield P., Langley D., Christ D., Yang J., Pajic M., Neely GG.
GENOME BIOLOGY 21 (1) :27, 2020 https://doi.org/10.1186/s13059-020-1940-8
Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody
Singh, M.; Jackson, K. J. L.; Wang, J. J.; Schofield, P.; Field, M. A.; Koppstein, D.; Peters, T. J.; Burnett, D. L.; Rizzetto, S.; Nevoltris, D.; Masle-Farquhar, E.; Faulks, M. L.; Russell, A.; Gokal, D.; Hanioka, A.; Horikawa, K.; Colella, A. D.; Chataway, T. K.; Blackburn, J.; Mercer, T. R.; Langley, D. B.; Goodall, D. M.; Jefferis, R.; Gangadharan Komala, M.; Kelleher, A. D.; Suan, D.; Rischmueller, M.; Christ, D.; Brink, R.; Luciani, F.; Gordon, T. P.; Goodnow, C. C.; Reed, J. H.
CELL 180 (5) :878-894 e19, 2020 10.1016/j.cell.2020.01.029
Protein A superantigen: structure, engineering and molecular basis of antibody recognition
Mazigi, O.; Schofield, P.; Langley, D. B.; Christ, D.
Protein Eng 32 (8) :359-366, 2019 10.1093/protein/gzz026
Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity
Zammit, N. W.; Siggs, O. M.; Gray, P. E.; Horikawa, K.; Langley, D. B.; Walters, S. N.; Daley, S. R.; Loetsch, C.; Warren, J.; Yap, J. Y.; Cultrone, D.; Russell, A.; Malle, E. K.; Villanueva, J. E.; Cowley, M. J.; Gayevskiy, V.; Dinger, M. E.; Brink, R.; Zahra, D.; Chaudhri, G.; Karupiah, G.; Whittle, B.; Roots, C.; Bertram, E.; Yamada, M.; Jeelall, Y.; Enders, A.; Clifton, B. E.; Mabbitt, P. D.; Jackson, C. J.; Watson, S. R.; Jenne, C. N.; Lanier, L. L.; Wiltshire, T.; Spitzer, M. H.; Nolan, G. P.; Schmitz, F.; Aderem, A.; Porebski, B. T.; Buckle, A. M.; Abbott, D. W.; Ziegler, J. B.; Craig, M. E.; Benitez-Aguirre, P.; Teo, J.; Tangye, S. G.; King, C.; Wong, M.; Cox, M. P.; Phung, W.; Tang, J.; Sandoval, W.; Wertz, I. E.; Christ, D.; Goodnow, C. C.; Grey, S. T.
NATURE IMMUNOLOGY 20 (10) :1299-1310, 2019 10.1038/s41590-019-0492-0
Human Antibody Bispecifics through Phage Display Selection
Luthra, A.; Langley, D. B.; Schofield, P.; Jackson, J.; Abdelatti, M.; Rouet, R.; Nevoltris, D.; Mazigi, O.; Crossett, B.; Christie, M.; Christ, D.
Biochemistry 58 (13) :1701-1704, 2019 10.1021/acs.biochem.9b00037
Crystal structure of duck egg lysozyme isoform II (DEL-II)
Langley, D. B.; Christ, D.
BMC STRUCTURAL BIOLOGY 18 (1) :10, 2018 10.1186/s12900-018-0090-7
OpenAccess publication I-motif DNA structures are formed in the nuclei of human cells
Zeraati, M.; Langley, D. B.; Schofield, P.; Moye, A. L.; Rouet, R.; Hughes, W. E.; Bryan, T. M.; Dinger, M. E.; Christ, D.
Nature Chemistry 10 (6) :631-637, 2018 10.1038/s41557-018-0046-3
Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination
Burnett, D. L.; Langley, D. B.; Schofield, P.; Hermes, J. R.; Chan, T. D.; Jackson, J.; Bourne, K.; Reed, J. H.; Patterson, K.; Porebski, B. T.; Brink, R.; Christ, D.; Goodnow, C. C.
SCIENCE 360 (6385) :223-226, 2018 10.1126/science.aao3859
Next-Generation Sequencing of Antibody Display Repertoires
Rouet, R.; Jackson, K. J. L.; Langley, D. B.; Christ, D.
Frontiers in Immunology 9 :118, 2018 10.3389/fimmu.2018.00118
Structural basis of antigen recognition: crystal structure of duck egg lysozyme
Langley, D. B.; Crossett, B.; Schofield, P.; Jackson, J.; Zeraati, M.; Maltby, D.; Christie, M.; Burnett, D.; Brink, R.; Goodnow, C.; Christ, D.
Acta Crystallographica Section D-Structural Biology 73 (Pt 11) :910-920, 2017 10.1107/S2059798317013730
OpenAccess publication Preparing monodisperse macromolecular samples for successful biological small-angle X-ray and neutron-scattering experiments
Jeffries, C. M. ; Graewert, M. A. ; Blanchet, C. E. ; Langley, D. B. ; Whitten, A. E. ; Svergun, D. I.;
Nature Protocols 11 (11) :2122-2153, 2016
OpenAccess publication Fully human VH single domains that rival the stability and cleft recognition of camelid antibodies
Rouet R.; Dudgeon K.; Christie M.; Langley D.; Christ D.
JOURNAL OF BIOLOGICAL CHEMISTRY 290 (19) :11905-17, 2015
Structure of GUN4 from Chlamydomonas reinhardtii
Tarahi Tabrizi, S. ; Langley, D. B. ; Harrop, S. J. ; Duff, A. P. ; Willows, R. D.;
Acta Crystallogr F Struct Biol Commun 71 (Pt 8) :1094-9, 2015
Redemption of autoantibodies on anergic B cells by V-region glycosylation and mutation away from self-reactivity
Sabouri Z, Schofield PR, Horikawa K, Spierings E, Kipling E, Randall K, Langley D, Roome B, Vazquez-Lombardi R, Rouet R, Hermes J, Chan T, Brink R, Dunn-Walters DK, Christ D and Goodnow CC
P NATL ACAD SCI USA 2014