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59 items matching your search terms.
Fats and Mets, KRAS-Driven Lipid Dysregulation Affects Metastatic Potential in Pancreatic Cancer
Man, J.; Pajic, M.; Joshua, A. M.
CANCER RESEARCH 80 (22) :4886-4887, 2020 10.1158/0008-5472.CAN-20-3082
Precision oncology in surgery: Patient selection for operable pancreatic cancer
Dreyer, S. B.; Pinese, M.; Jamieson, N. B.; Scarlett, C. J.; Colvin, E. K.; Pajic, M.; Johns, A. L.; Humphris, J. L.; Wu, J.; Cowley, M. J.; Chou, A.; Nagrial, A. M.; Chantrill, L.; Chin, V. T.; Jones, M. D.; Moran-Jones, K.; Carter, C. R.; Dickson, E. J.; Samra, J. S.; Merrett, N. D.; Gill, A. J.; Kench, J. G.; Duthie, F.; Miller, D. K.; Cooke, S.; Aust, D.; Knosel, T.; Rummele, P.; Grutzmann, R.; Pilarsky, C.; Nguyen, N. Q.; Musgrove, E. A.; Bailey, P. J.; McKay, C. J.; Biankin, A. V.; Chang, D. K.; Australian Pancreatic Cancer Genome, Initiative; Glasgow Precision Oncology, Laboratory
ANNALS OF SURGERY 272 (2) :366-376, 2020 10.1097/SLA.0000000000003143
MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer
Cipponi, A.; Goode, D. L.; Bedo, J.; McCabe, M. J.; Pajic, M.; Croucher, D. R.; Rajal, A. G.; Junankar, S. R.; Saunders, D. N.; Lobachevsky, P.; Papenfuss, A. T.; Nessem, D.; Nobis, M.; Warren, S. C.; Timpson, P.; Cowley, M.; Vargas, A. C.; Qiu, M. R.; Generali, D. G.; Keerthikumar, S.; Nguyen, U.; Corcoran, N. M.; Long, G. V.; Blay, J. Y.; Thomas, D. M.
SCIENCE 368 (6495) :1127-1131, 2020 10.1126/science.aau8768
OpenAccess publication HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer
Brunton, H.; Caligiuri, G.; Cunningham, R.; Upstill-Goddard, R.; Bailey, U. M.; Garner, I. M.; Nourse, C.; Dreyer, S.; Jones, M.; Moran-Jones, K.; Wright, D. W.; Paulus-Hock, V.; Nixon, C.; Thomson, G.; Jamieson, N. B.; McGregor, G. A.; Evers, L.; McKay, C. J.; Gulati, A.; Brough, R.; Bajrami, I.; Pettitt, S. J.; Dziubinski, M. L.; Barry, S. T.; Grutzmann, R.; Brown, R.; Curry, E.; Glasgow Precision Oncology, Laboratory; Australian Pancreatic Cancer Genome, Initiative; Pajic, M.; Musgrove, E. A.; Petersen, G. M.; Shanks, E.; Ashworth, A.; Crawford, H. C.; Simeone, D. M.; Froeling, F. E. M.; Lord, C. J.; Mukhopadhyay, D.; Pilarsky, C.; Grimmond, S. E.; Morton, J. P.; Sansom, O. J.; Chang, D. K.; Bailey, P. J.; Biankin, A. V.
Cell Reports 31 (6) :107625, 2020 10.1016/j.celrep.2020.107625
RET gene rearrangements occur in a subset of pancreatic acinar cell carcinomas
Chou, A.; Brown, I. S.; Kumarasinghe, M. P.; Perren, A.; Riley, D.; Kim, Y.; Pajic, M.; Steinmann, A.; Rathi, V.; Jamieson, N. B.; Verheij, J.; van Roessel, S.; Nahm, C. B.; Mittal, A.; Samra, J.; Gill, A. J.
MODERN PATHOLOGY 33 (4) :657-664, 2020 10.1038/s41379-019-0373-y
Effective targeting of intact and proteolysed CDCP1 for imaging and treatment of pancreatic ductal adenocarcinoma
Kryza, T.; Khan, T.; Puttick, S.; Li, C.; Sokolowski, K. A.; Tse, B. W.; Cuda, T.; Lyons, N.; Gough, M.; Yin, J.; Parkin, A.; Deryugina, E. I.; Quigley, J. P.; Law, R. H. P.; Whisstock, J. C.; Riddell, A. D.; Barbour, A. P.; Wyld, D. K.; Thomas, P. A.; Rose, S.; Snell, C. E.; Pajic, M.; He, Y.; Hooper, J. D.
Theranostics 10 (9) :4116-4133, 2020 10.7150/thno.43589
OpenAccess publication Systematic functional identification of cancer multi-drug resistance genes
Lau MT., Ghazanfar S., Parkin A., Chou A., Rouaen JR., Littleboy JB., Nessem D., Khuong TM., Nevoltris D., Schofield P., Langley D., Christ D., Yang J., Pajic M., Neely GG.
GENOME BIOLOGY 21 (1) :27, 2020
MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma
Castillo, L.; Young, A. I. J.; Mawson, A.; Schafranek, P.; Steinmann, A. M.; Nessem, D.; Parkin, A.; Johns, A.; Chou, A.; Law, A. M. K.; Lucas, M. C.; Murphy, K. J.; Deng, N.; Gallego-Ortega, D.; Caldon, C. E.; Australian Pancreatic Cancer Genome, Initiative; Timpson, P.; Pajic, M.; Ormandy, C. J.; Oakes, S. R.
ONCOGENE 39 (8) :1821-1829, 2020 10.1038/s41388-019-1091-0
Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy
Vennin, C.; Rath, N.; Pajic, M.; Olson, M. F.; Timpson, P.
Small GTPases 11 (1) :45-52, 2020 10.1080/21541248.2017.1345712
Targeting the complexity of Src signalling in the tumour microenvironment of pancreatic cancer: from mechanism to therapy
Parkin, A.; Man, J.; Timpson, P.; Pajic, M.
FEBS Journal 286 (18) :3510-3539, 2019 10.1111/febs.15011
OpenAccess publication CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan
Vennin, C.; Melenec, P.; Rouet, R.; Nobis, M.; Cazet, A. S.; Murphy, K. J.; Herrmann, D.; Reed, D. A.; Lucas, M. C.; Warren, S. C.; Elgundi, Z.; Pinese, M.; Kalna, G.; Roden, D.; Samuel, M.; Zaratzian, A.; Grey, S. T.; Da Silva, A.; Leung, W.; Mathivanan, S.; Wang, Y.; Braithwaite, A. W.; Christ, D.; Benda, A.; Parkin, A.; Phillips, P. A.; Whitelock, J. M.; Gill, A. J.; Sansom, O. J.; Croucher, D. R.; Parker, B. L.; Pajic, M.; Morton, J. P.; Cox, T. R.; Timpson, P.
Nature Communications 10 (1) :3637, 2019 10.1038/s41467-019-10968-6
PAK inhibition by PF-3758309 enhanced the sensitivity of multiple chemotherapeutic reagents in patient-derived pancreatic cancer cell lines
Wang, K.; Huynh, N.; Wang, X.; Pajic, M.; Parkin, A.; Man, J.; Baldwin, G. S.; Nikfarjam, M.; He, H.
American Journal of Translational Research 11 (6) :3353-3364, 2019
OpenAccess publication ATRX loss is an independent predictor of poor survival in pancreatic neuroendocrine tumours
Chou, A.; Itchins, M.; de Reuver, P.R.; Arena, J.; Clarkson, A.; Sheen, A.; Sioson, L.; Cheung, V.; Perren, A.; Nahm, C.; Mittal, A.; Samra, J. S.; Pajic, M.; Gill, A. J.
HUMAN PATHOLOGY 82 :249-257, 2018 10.1016/j.humpath.2018.07.032
OpenAccess publication Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer
Chou, A.; Froio, D.; Nagrial, A. M.; Parkin, A.; Murphy, K. J.; Chin, V. T.; Wohl, D.; Steinmann, A.; Stark, R.; Drury, A.; Walters, S. N.; Vennin, C.; Burgess, A.; Pinese, M.; Chantrill, L. A.; Cowley, M. J.; Molloy, T. J.; Waddell, N.; Johns, A.; Grimmond, S. M.; Chang, D. K.; Biankin, A. V.; Sansom, O. J.; Morton, J. P.; Grey, S. T.; Cox, T. R.; Turchini, J.; Samra, J.; Clarke, S. J.; Timpson, P.; Gill, A. J.; Pajic, M.
GUT 67 (12) :2142-2155, 2018 10.1136/gutjnl-2017-315144
The Evolving Understanding of the Molecular and Therapeutic Landscape of Pancreatic Ductal Adenocarcinoma
Parkin, A.; Man, J.; Chou, A.; Nagrial, A. M.; Samra, J.; Gill, A. J.; Timpson, P.; Pajic, M.
Diseases 6 (4) :103, 2018 10.3390/diseases6040103
Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors
Hoque, M.; Abbassi, R. H.; Froio, D.; Man, J.; Johns, T. G.; Stringer, B. W.; Day, B. W.; Pajic, M.; Kassiou, M.; Munoz, L.
PHARMACOLOGICAL RESEARCH 134 :166-178, 2018 10.1016/j.phrs.2018.06.023