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66 items matching your search terms.
Oral Squamous Cell Carcinoma in Young Patients Show Higher Rates of EGFR Amplification: Implications for Novel Personalized Therapy
Satgunaseelan, L.; Porazinski, S.; Strbenac, D.; Istadi, A.; Willet, C.; Chew, T.; Sadsad, R.; Palme, C. E.; Lee, J. H.; Boyer, M.; Yang, J. Y. H.; Clark, J. R.; Pajic, M.; Gupta, R.
Frontiers in Oncology 11 :750852, 2021 10.3389/fonc.2021.750852
TLR2 activation promotes tumour growth and associates with patient survival and chemotherapy response in pancreatic ductal adenocarcinoma
Lundy, J.; Gearing, L. J.; Gao, H.; West, A. C.; McLeod, L.; Deswaerte, V.; Yu, L.; Porazinski, S.; Pajic, M.; Hertzog, P. J.; Croagh, D.; Jenkins, B. J.
ONCOGENE 2021 10.1038/s41388-021-01992-2
Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status
Murphy, K. J.; Reed, D. A.; Vennin, C.; Conway, J. R. W.; Nobis, M.; Yin, J. X.; Chambers, C. R.; Pereira, B. A.; Lee, V.; Filipe, E. C.; Trpceski, M.; Ritchie, S.; Lucas, M. C.; Warren, S. C.; Skhinas, J. N.; Magenau, A.; Metcalf, X. L.; Stoehr, J.; Major, G.; Parkin, A.; Bidanel, R.; Lyons, R. J.; Zaratzian, A.; Tayao, M.; Da Silva, A.; Abdulkhalek, L.; Australian Pancreatic Genome, Initiative; Australian Pancreatic Cancer Matrix, Atlas; Gill, A. J.; Johns, A. L.; Biankin, A. V.; Samra, J.; Grimmond, S. M.; Chou, A.; Goetz, J. G.; Samuel, M. S.; Lyons, J. G.; Burgess, A.; Caldon, C. E.; Horvath, L. G.; Daly, R. J.; Gadegaard, N.; Wang, Y.; Sansom, O. J.; Morton, J. P.; Cox, T. R.; Pajic, M.; Herrmann, D.; Timpson, P.
Science Advances 7 (40) :eabh0363, 2021 10.1126/sciadv.abh0363
Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition
Sharbeen, G.; McCarroll, J. A.; Akerman, A.; Kopecky, C.; Youkhana, J.; Kokkinos, J.; Holst, J.; Boyer, C.; Erkan, M.; Goldstein, D.; Timpson, P.; Cox, T. R.; Pereira, B. A.; Chitty, J. L.; Fey, S. K.; Najumudeen, A. K.; Campbell, A. D.; Sansom, O. J.; Ignacio, R. M. C.; Naim, S.; Liu, J.; Russia, N.; Lee, J.; Chou, A.; Johns, A.; Gill, A. J.; Gonzales-Aloy, E.; Gebski, V.; Guan, Y. F.; Pajic, M.; Turner, N.; Apte, M. V.; Davis, T. P.; Morton, J. P.; Haghighi, K. S.; Kasparian, J.; McLean, B. J.; Setargew, Y. F.; Phillips, P. A.; Australian Pancreatic Cancer Genome, Initiative
CANCER RESEARCH 81 (13) :3461-3479, 2021 10.1158/0008-5472.CAN-20-2496
Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1
Kryza, T.; Khan, T.; Lovell, S.; Harrington, B. S.; Yin, J.; Porazinski, S.; Pajic, M.; Koistinen, H.; Rantala, J. K.; Dreyer, T.; Magdolen, V.; Reuning, U.; He, Y.; Tate, E. W.; Hooper, J. D.
Nature Chemical Biology 17 (7) :776-783, 2021 10.1038/s41589-021-00783-w
Breaking the cycle: Targeting of NDRG1 to inhibit bi-directional oncogenic cross-talk between pancreatic cancer and stroma
Geleta, B.; Park, K. C.; Jansson, P. J.; Sahni, S.; Maleki, S.; Xu, Z.; Murakami, T.; Pajic, M.; Apte, M. V.; Richardson, D. R.; Kovacevic, Z.
FASEB JOURNAL 35 (2) :e21347, 2021 10.1096/fj.202002279R
Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer
Dreyer, S. B.; Upstill-Goddard, R.; Paulus-Hock, V.; Paris, C.; Lampraki, E. M.; Dray, E.; Serrels, B.; Caligiuri, G.; Rebus, S.; Plenker, D.; Galluzzo, Z.; Brunton, H.; Cunningham, R.; Tesson, M.; Nourse, C.; Bailey, U. M.; Jones, M.; Moran-Jones, K.; Wright, D. W.; Duthie, F.; Oien, K.; Evers, L.; McKay, C. J.; McGregor, G. A.; Gulati, A.; Brough, R.; Bajrami, I.; Pettitt, S.; Dziubinski, M. L.; Candido, J.; Balkwill, F.; Barry, S. T.; Grutzmann, R.; Rahib, L.; Glasgow Precision Oncology, Laboratory; Australian Pancreatic Cancer Genome, Initiative; Johns, A.; Pajic, M.; Froeling, F. E. M.; Beer, P.; Musgrove, E. A.; Petersen, G. M.; Ashworth, A.; Frame, M. C.; Crawford, H. C.; Simeone, D. M.; Lord, C.; Mukhopadhyay, D.; Pilarsky, C.; Tuveson, D. A.; Cooke, S. L.; Jamieson, N. B.; Morton, J. P.; Sansom, O. J.; Bailey, P. J.; Biankin, A. V.; Chang, D. K.
GASTROENTEROLOGY 160 (1) :362-377 e13, 2021 10.1053/j.gastro.2020.09.043
Fats and Mets, KRAS-Driven Lipid Dysregulation Affects Metastatic Potential in Pancreatic Cancer
Man, J.; Pajic, M.; Joshua, A. M.
CANCER RESEARCH 80 (22) :4886-4887, 2020 10.1158/0008-5472.CAN-20-3082
Precision oncology in surgery: Patient selection for operable pancreatic cancer
Dreyer, S. B.; Pinese, M.; Jamieson, N. B.; Scarlett, C. J.; Colvin, E. K.; Pajic, M.; Johns, A. L.; Humphris, J. L.; Wu, J.; Cowley, M. J.; Chou, A.; Nagrial, A. M.; Chantrill, L.; Chin, V. T.; Jones, M. D.; Moran-Jones, K.; Carter, C. R.; Dickson, E. J.; Samra, J. S.; Merrett, N. D.; Gill, A. J.; Kench, J. G.; Duthie, F.; Miller, D. K.; Cooke, S.; Aust, D.; Knosel, T.; Rummele, P.; Grutzmann, R.; Pilarsky, C.; Nguyen, N. Q.; Musgrove, E. A.; Bailey, P. J.; McKay, C. J.; Biankin, A. V.; Chang, D. K.; Australian Pancreatic Cancer Genome, Initiative; Glasgow Precision Oncology, Laboratory
ANNALS OF SURGERY 272 (2) :366-376, 2020 10.1097/SLA.0000000000003143
MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer
Cipponi, A.; Goode, D. L.; Bedo, J.; McCabe, M. J.; Pajic, M.; Croucher, D. R.; Rajal, A. G.; Junankar, S. R.; Saunders, D. N.; Lobachevsky, P.; Papenfuss, A. T.; Nessem, D.; Nobis, M.; Warren, S. C.; Timpson, P.; Cowley, M.; Vargas, A. C.; Qiu, M. R.; Generali, D. G.; Keerthikumar, S.; Nguyen, U.; Corcoran, N. M.; Long, G. V.; Blay, J. Y.; Thomas, D. M.
SCIENCE 368 (6495) :1127-1131, 2020 10.1126/science.aau8768
OpenAccess publication HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer
Brunton, H.; Caligiuri, G.; Cunningham, R.; Upstill-Goddard, R.; Bailey, U. M.; Garner, I. M.; Nourse, C.; Dreyer, S.; Jones, M.; Moran-Jones, K.; Wright, D. W.; Paulus-Hock, V.; Nixon, C.; Thomson, G.; Jamieson, N. B.; McGregor, G. A.; Evers, L.; McKay, C. J.; Gulati, A.; Brough, R.; Bajrami, I.; Pettitt, S. J.; Dziubinski, M. L.; Barry, S. T.; Grutzmann, R.; Brown, R.; Curry, E.; Glasgow Precision Oncology, Laboratory; Australian Pancreatic Cancer Genome, Initiative; Pajic, M.; Musgrove, E. A.; Petersen, G. M.; Shanks, E.; Ashworth, A.; Crawford, H. C.; Simeone, D. M.; Froeling, F. E. M.; Lord, C. J.; Mukhopadhyay, D.; Pilarsky, C.; Grimmond, S. E.; Morton, J. P.; Sansom, O. J.; Chang, D. K.; Bailey, P. J.; Biankin, A. V.
Cell Reports 31 (6) :107625, 2020 10.1016/j.celrep.2020.107625
RET gene rearrangements occur in a subset of pancreatic acinar cell carcinomas
Chou, A.; Brown, I. S.; Kumarasinghe, M. P.; Perren, A.; Riley, D.; Kim, Y.; Pajic, M.; Steinmann, A.; Rathi, V.; Jamieson, N. B.; Verheij, J.; van Roessel, S.; Nahm, C. B.; Mittal, A.; Samra, J.; Gill, A. J.
MODERN PATHOLOGY 33 (4) :657-664, 2020 10.1038/s41379-019-0373-y
Effective targeting of intact and proteolysed CDCP1 for imaging and treatment of pancreatic ductal adenocarcinoma
Kryza, T.; Khan, T.; Puttick, S.; Li, C.; Sokolowski, K. A.; Tse, B. W.; Cuda, T.; Lyons, N.; Gough, M.; Yin, J.; Parkin, A.; Deryugina, E. I.; Quigley, J. P.; Law, R. H. P.; Whisstock, J. C.; Riddell, A. D.; Barbour, A. P.; Wyld, D. K.; Thomas, P. A.; Rose, S.; Snell, C. E.; Pajic, M.; He, Y.; Hooper, J. D.
Theranostics 10 (9) :4116-4133, 2020 10.7150/thno.43589
OpenAccess publication Systematic functional identification of cancer multi-drug resistance genes
Lau MT., Ghazanfar S., Parkin A., Chou A., Rouaen JR., Littleboy JB., Nessem D., Khuong TM., Nevoltris D., Schofield P., Langley D., Christ D., Yang J., Pajic M., Neely GG.
GENOME BIOLOGY 21 (1) :27, 2020 https://doi.org/10.1186/s13059-020-1940-8
MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma
Castillo, L.; Young, A. I. J.; Mawson, A.; Schafranek, P.; Steinmann, A. M.; Nessem, D.; Parkin, A.; Johns, A.; Chou, A.; Law, A. M. K.; Lucas, M. C.; Murphy, K. J.; Deng, N.; Gallego-Ortega, D.; Caldon, C. E.; Australian Pancreatic Cancer Genome, Initiative; Timpson, P.; Pajic, M.; Ormandy, C. J.; Oakes, S. R.
ONCOGENE 39 (8) :1821-1829, 2020 10.1038/s41388-019-1091-0
Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy
Vennin, C.; Rath, N.; Pajic, M.; Olson, M. F.; Timpson, P.
Small GTPases 11 (1) :45-52, 2020 10.1080/21541248.2017.1345712