66 items matching your search terms.
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Oral Squamous Cell Carcinoma in Young Patients Show Higher Rates of EGFR Amplification: Implications for Novel Personalized Therapy
- Satgunaseelan, L.; Porazinski, S.; Strbenac, D.; Istadi, A.; Willet, C.; Chew, T.; Sadsad, R.; Palme, C. E.; Lee, J. H.; Boyer, M.; Yang, J. Y. H.; Clark, J. R.; Pajic, M.; Gupta, R.
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Frontiers in Oncology
11
:750852,
2021
10.3389/fonc.2021.750852
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TLR2 activation promotes tumour growth and associates with patient survival and chemotherapy response in pancreatic ductal adenocarcinoma
- Lundy, J.; Gearing, L. J.; Gao, H.; West, A. C.; McLeod, L.; Deswaerte, V.; Yu, L.; Porazinski, S.; Pajic, M.; Hertzog, P. J.; Croagh, D.; Jenkins, B. J.
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ONCOGENE
2021
10.1038/s41388-021-01992-2
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Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status
- Murphy, K. J.; Reed, D. A.; Vennin, C.; Conway, J. R. W.; Nobis, M.; Yin, J. X.; Chambers, C. R.; Pereira, B. A.; Lee, V.; Filipe, E. C.; Trpceski, M.; Ritchie, S.; Lucas, M. C.; Warren, S. C.; Skhinas, J. N.; Magenau, A.; Metcalf, X. L.; Stoehr, J.; Major, G.; Parkin, A.; Bidanel, R.; Lyons, R. J.; Zaratzian, A.; Tayao, M.; Da Silva, A.; Abdulkhalek, L.; Australian Pancreatic Genome, Initiative; Australian Pancreatic Cancer Matrix, Atlas; Gill, A. J.; Johns, A. L.; Biankin, A. V.; Samra, J.; Grimmond, S. M.; Chou, A.; Goetz, J. G.; Samuel, M. S.; Lyons, J. G.; Burgess, A.; Caldon, C. E.; Horvath, L. G.; Daly, R. J.; Gadegaard, N.; Wang, Y.; Sansom, O. J.; Morton, J. P.; Cox, T. R.; Pajic, M.; Herrmann, D.; Timpson, P.
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Science Advances
7
(40)
:eabh0363,
2021
10.1126/sciadv.abh0363
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Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition
- Sharbeen, G.; McCarroll, J. A.; Akerman, A.; Kopecky, C.; Youkhana, J.; Kokkinos, J.; Holst, J.; Boyer, C.; Erkan, M.; Goldstein, D.; Timpson, P.; Cox, T. R.; Pereira, B. A.; Chitty, J. L.; Fey, S. K.; Najumudeen, A. K.; Campbell, A. D.; Sansom, O. J.; Ignacio, R. M. C.; Naim, S.; Liu, J.; Russia, N.; Lee, J.; Chou, A.; Johns, A.; Gill, A. J.; Gonzales-Aloy, E.; Gebski, V.; Guan, Y. F.; Pajic, M.; Turner, N.; Apte, M. V.; Davis, T. P.; Morton, J. P.; Haghighi, K. S.; Kasparian, J.; McLean, B. J.; Setargew, Y. F.; Phillips, P. A.; Australian Pancreatic Cancer Genome, Initiative
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CANCER RESEARCH
81
(13)
:3461-3479,
2021
10.1158/0008-5472.CAN-20-2496
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Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1
- Kryza, T.; Khan, T.; Lovell, S.; Harrington, B. S.; Yin, J.; Porazinski, S.; Pajic, M.; Koistinen, H.; Rantala, J. K.; Dreyer, T.; Magdolen, V.; Reuning, U.; He, Y.; Tate, E. W.; Hooper, J. D.
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Nature Chemical Biology
17
(7)
:776-783,
2021
10.1038/s41589-021-00783-w
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Breaking the cycle: Targeting of NDRG1 to inhibit bi-directional oncogenic cross-talk between pancreatic cancer and stroma
- Geleta, B.; Park, K. C.; Jansson, P. J.; Sahni, S.; Maleki, S.; Xu, Z.; Murakami, T.; Pajic, M.; Apte, M. V.; Richardson, D. R.; Kovacevic, Z.
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FASEB JOURNAL
35
(2)
:e21347,
2021
10.1096/fj.202002279R
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Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer
- Dreyer, S. B.; Upstill-Goddard, R.; Paulus-Hock, V.; Paris, C.; Lampraki, E. M.; Dray, E.; Serrels, B.; Caligiuri, G.; Rebus, S.; Plenker, D.; Galluzzo, Z.; Brunton, H.; Cunningham, R.; Tesson, M.; Nourse, C.; Bailey, U. M.; Jones, M.; Moran-Jones, K.; Wright, D. W.; Duthie, F.; Oien, K.; Evers, L.; McKay, C. J.; McGregor, G. A.; Gulati, A.; Brough, R.; Bajrami, I.; Pettitt, S.; Dziubinski, M. L.; Candido, J.; Balkwill, F.; Barry, S. T.; Grutzmann, R.; Rahib, L.; Glasgow Precision Oncology, Laboratory; Australian Pancreatic Cancer Genome, Initiative; Johns, A.; Pajic, M.; Froeling, F. E. M.; Beer, P.; Musgrove, E. A.; Petersen, G. M.; Ashworth, A.; Frame, M. C.; Crawford, H. C.; Simeone, D. M.; Lord, C.; Mukhopadhyay, D.; Pilarsky, C.; Tuveson, D. A.; Cooke, S. L.; Jamieson, N. B.; Morton, J. P.; Sansom, O. J.; Bailey, P. J.; Biankin, A. V.; Chang, D. K.
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GASTROENTEROLOGY
160
(1)
:362-377 e13,
2021
10.1053/j.gastro.2020.09.043
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Fats and Mets, KRAS-Driven Lipid Dysregulation Affects Metastatic Potential in Pancreatic Cancer
- Man, J.; Pajic, M.; Joshua, A. M.
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CANCER RESEARCH
80
(22)
:4886-4887,
2020
10.1158/0008-5472.CAN-20-3082
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Precision oncology in surgery: Patient selection for operable pancreatic cancer
- Dreyer, S. B.; Pinese, M.; Jamieson, N. B.; Scarlett, C. J.; Colvin, E. K.; Pajic, M.; Johns, A. L.; Humphris, J. L.; Wu, J.; Cowley, M. J.; Chou, A.; Nagrial, A. M.; Chantrill, L.; Chin, V. T.; Jones, M. D.; Moran-Jones, K.; Carter, C. R.; Dickson, E. J.; Samra, J. S.; Merrett, N. D.; Gill, A. J.; Kench, J. G.; Duthie, F.; Miller, D. K.; Cooke, S.; Aust, D.; Knosel, T.; Rummele, P.; Grutzmann, R.; Pilarsky, C.; Nguyen, N. Q.; Musgrove, E. A.; Bailey, P. J.; McKay, C. J.; Biankin, A. V.; Chang, D. K.; Australian Pancreatic Cancer Genome, Initiative; Glasgow Precision Oncology, Laboratory
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ANNALS OF SURGERY
272
(2)
:366-376,
2020
10.1097/SLA.0000000000003143
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MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer
- Cipponi, A.; Goode, D. L.; Bedo, J.; McCabe, M. J.; Pajic, M.; Croucher, D. R.; Rajal, A. G.; Junankar, S. R.; Saunders, D. N.; Lobachevsky, P.; Papenfuss, A. T.; Nessem, D.; Nobis, M.; Warren, S. C.; Timpson, P.; Cowley, M.; Vargas, A. C.; Qiu, M. R.; Generali, D. G.; Keerthikumar, S.; Nguyen, U.; Corcoran, N. M.; Long, G. V.; Blay, J. Y.; Thomas, D. M.
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SCIENCE
368
(6495)
:1127-1131,
2020
10.1126/science.aau8768
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HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer
- Brunton, H.; Caligiuri, G.; Cunningham, R.; Upstill-Goddard, R.; Bailey, U. M.; Garner, I. M.; Nourse, C.; Dreyer, S.; Jones, M.; Moran-Jones, K.; Wright, D. W.; Paulus-Hock, V.; Nixon, C.; Thomson, G.; Jamieson, N. B.; McGregor, G. A.; Evers, L.; McKay, C. J.; Gulati, A.; Brough, R.; Bajrami, I.; Pettitt, S. J.; Dziubinski, M. L.; Barry, S. T.; Grutzmann, R.; Brown, R.; Curry, E.; Glasgow Precision Oncology, Laboratory; Australian Pancreatic Cancer Genome, Initiative; Pajic, M.; Musgrove, E. A.; Petersen, G. M.; Shanks, E.; Ashworth, A.; Crawford, H. C.; Simeone, D. M.; Froeling, F. E. M.; Lord, C. J.; Mukhopadhyay, D.; Pilarsky, C.; Grimmond, S. E.; Morton, J. P.; Sansom, O. J.; Chang, D. K.; Bailey, P. J.; Biankin, A. V.
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Cell Reports
31
(6)
:107625,
2020
10.1016/j.celrep.2020.107625
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RET gene rearrangements occur in a subset of pancreatic acinar cell carcinomas
- Chou, A.; Brown, I. S.; Kumarasinghe, M. P.; Perren, A.; Riley, D.; Kim, Y.; Pajic, M.; Steinmann, A.; Rathi, V.; Jamieson, N. B.; Verheij, J.; van Roessel, S.; Nahm, C. B.; Mittal, A.; Samra, J.; Gill, A. J.
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MODERN PATHOLOGY
33
(4)
:657-664,
2020
10.1038/s41379-019-0373-y
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Effective targeting of intact and proteolysed CDCP1 for imaging and treatment of pancreatic ductal adenocarcinoma
- Kryza, T.; Khan, T.; Puttick, S.; Li, C.; Sokolowski, K. A.; Tse, B. W.; Cuda, T.; Lyons, N.; Gough, M.; Yin, J.; Parkin, A.; Deryugina, E. I.; Quigley, J. P.; Law, R. H. P.; Whisstock, J. C.; Riddell, A. D.; Barbour, A. P.; Wyld, D. K.; Thomas, P. A.; Rose, S.; Snell, C. E.; Pajic, M.; He, Y.; Hooper, J. D.
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Theranostics
10
(9)
:4116-4133,
2020
10.7150/thno.43589
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Systematic functional identification of cancer multi-drug resistance genes
- Lau MT., Ghazanfar S., Parkin A., Chou A., Rouaen JR., Littleboy JB., Nessem D., Khuong TM., Nevoltris D., Schofield P., Langley D., Christ D., Yang J., Pajic M., Neely GG.
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GENOME BIOLOGY
21
(1)
:27,
2020
https://doi.org/10.1186/s13059-020-1940-8
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MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma
- Castillo, L.; Young, A. I. J.; Mawson, A.; Schafranek, P.; Steinmann, A. M.; Nessem, D.; Parkin, A.; Johns, A.; Chou, A.; Law, A. M. K.; Lucas, M. C.; Murphy, K. J.; Deng, N.; Gallego-Ortega, D.; Caldon, C. E.; Australian Pancreatic Cancer Genome, Initiative; Timpson, P.; Pajic, M.; Ormandy, C. J.; Oakes, S. R.
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ONCOGENE
39
(8)
:1821-1829,
2020
10.1038/s41388-019-1091-0
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Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy
- Vennin, C.; Rath, N.; Pajic, M.; Olson, M. F.; Timpson, P.
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Small GTPases
11
(1)
:45-52,
2020
10.1080/21541248.2017.1345712