Garvan Institute of Medical Research

Fats and Mets, KRAS-Driven Lipid Dysregulation Affects Metastatic Potential in Pancreatic Cancer

Man, J.; Pajic, M.; Joshua, A. M.

CANCER RESEARCH 80 (22) :4886-4887, 2020 10.1158/0008-5472.CAN-20-3082

Precision oncology in surgery: Patient selection for operable pancreatic cancer

Dreyer, S. B.; Pinese, M.; Jamieson, N. B.; Scarlett, C. J.; Colvin, E. K.; Pajic, M.; Johns, A. L.; Humphris, J. L.; Wu, J.; Cowley, M. J.; Chou, A.; Nagrial, A. M.; Chantrill, L.; Chin, V. T.; Jones, M. D.; Moran-Jones, K.; Carter, C. R.; Dickson, E. J.; Samra, J. S.; Merrett, N. D.; Gill, A. J.; Kench, J. G.; Duthie, F.; Miller, D. K.; Cooke, S.; Aust, D.; Knosel, T.; Rummele, P.; Grutzmann, R.; Pilarsky, C.; Nguyen, N. Q.; Musgrove, E. A.; Bailey, P. J.; McKay, C. J.; Biankin, A. V.; Chang, D. K.; Australian Pancreatic Cancer Genome, Initiative; Glasgow Precision Oncology, Laboratory

ANNALS OF SURGERY 272 (2) :366-376, 2020 10.1097/SLA.0000000000003143

MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer

Cipponi, A.; Goode, D. L.; Bedo, J.; McCabe, M. J.; Pajic, M.; Croucher, D. R.; Rajal, A. G.; Junankar, S. R.; Saunders, D. N.; Lobachevsky, P.; Papenfuss, A. T.; Nessem, D.; Nobis, M.; Warren, S. C.; Timpson, P.; Cowley, M.; Vargas, A. C.; Qiu, M. R.; Generali, D. G.; Keerthikumar, S.; Nguyen, U.; Corcoran, N. M.; Long, G. V.; Blay, J. Y.; Thomas, D. M.

SCIENCE 368 (6495) :1127-1131, 2020 10.1126/science.aau8768

HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer

Brunton, H.; Caligiuri, G.; Cunningham, R.; Upstill-Goddard, R.; Bailey, U. M.; Garner, I. M.; Nourse, C.; Dreyer, S.; Jones, M.; Moran-Jones, K.; Wright, D. W.; Paulus-Hock, V.; Nixon, C.; Thomson, G.; Jamieson, N. B.; McGregor, G. A.; Evers, L.; McKay, C. J.; Gulati, A.; Brough, R.; Bajrami, I.; Pettitt, S. J.; Dziubinski, M. L.; Barry, S. T.; Grutzmann, R.; Brown, R.; Curry, E.; Glasgow Precision Oncology, Laboratory; Australian Pancreatic Cancer Genome, Initiative; Pajic, M.; Musgrove, E. A.; Petersen, G. M.; Shanks, E.; Ashworth, A.; Crawford, H. C.; Simeone, D. M.; Froeling, F. E. M.; Lord, C. J.; Mukhopadhyay, D.; Pilarsky, C.; Grimmond, S. E.; Morton, J. P.; Sansom, O. J.; Chang, D. K.; Bailey, P. J.; Biankin, A. V.

Cell Reports 31 (6) :107625, 2020 10.1016/j.celrep.2020.107625

RET gene rearrangements occur in a subset of pancreatic acinar cell carcinomas

Chou, A.; Brown, I. S.; Kumarasinghe, M. P.; Perren, A.; Riley, D.; Kim, Y.; Pajic, M.; Steinmann, A.; Rathi, V.; Jamieson, N. B.; Verheij, J.; van Roessel, S.; Nahm, C. B.; Mittal, A.; Samra, J.; Gill, A. J.

MODERN PATHOLOGY 33 (4) :657-664, 2020 10.1038/s41379-019-0373-y

Effective targeting of intact and proteolysed CDCP1 for imaging and treatment of pancreatic ductal adenocarcinoma

Kryza, T.; Khan, T.; Puttick, S.; Li, C.; Sokolowski, K. A.; Tse, B. W.; Cuda, T.; Lyons, N.; Gough, M.; Yin, J.; Parkin, A.; Deryugina, E. I.; Quigley, J. P.; Law, R. H. P.; Whisstock, J. C.; Riddell, A. D.; Barbour, A. P.; Wyld, D. K.; Thomas, P. A.; Rose, S.; Snell, C. E.; Pajic, M.; He, Y.; Hooper, J. D.

Theranostics 10 (9) :4116-4133, 2020 10.7150/thno.43589

Systematic functional identification of cancer multi-drug resistance genes

Lau MT., Ghazanfar S., Parkin A., Chou A., Rouaen JR., Littleboy JB., Nessem D., Khuong TM., Nevoltris D., Schofield P., Langley D., Christ D., Yang J., Pajic M., Neely GG.

GENOME BIOLOGY 21 (1) :27, 2020 https://doi.org/10.1186/s13059-020-1940-8

MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma

Castillo, L.; Young, A. I. J.; Mawson, A.; Schafranek, P.; Steinmann, A. M.; Nessem, D.; Parkin, A.; Johns, A.; Chou, A.; Law, A. M. K.; Lucas, M. C.; Murphy, K. J.; Deng, N.; Gallego-Ortega, D.; Caldon, C. E.; Australian Pancreatic Cancer Genome, Initiative; Timpson, P.; Pajic, M.; Ormandy, C. J.; Oakes, S. R.

ONCOGENE 39 (8) :1821-1829, 2020 10.1038/s41388-019-1091-0

Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy

Vennin, C.; Rath, N.; Pajic, M.; Olson, M. F.; Timpson, P.

Small GTPases 11 (1) :45-52, 2020 10.1080/21541248.2017.1345712

Targeting the complexity of Src signalling in the tumour microenvironment of pancreatic cancer: from mechanism to therapy

Parkin, A.; Man, J.; Timpson, P.; Pajic, M.

FEBS Journal 286 (18) :3510-3539, 2019 10.1111/febs.15011

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

Vennin, C.; Melenec, P.; Rouet, R.; Nobis, M.; Cazet, A. S.; Murphy, K. J.; Herrmann, D.; Reed, D. A.; Lucas, M. C.; Warren, S. C.; Elgundi, Z.; Pinese, M.; Kalna, G.; Roden, D.; Samuel, M.; Zaratzian, A.; Grey, S. T.; Da Silva, A.; Leung, W.; Mathivanan, S.; Wang, Y.; Braithwaite, A. W.; Christ, D.; Benda, A.; Parkin, A.; Phillips, P. A.; Whitelock, J. M.; Gill, A. J.; Sansom, O. J.; Croucher, D. R.; Parker, B. L.; Pajic, M.; Morton, J. P.; Cox, T. R.; Timpson, P.

Nature Communications 10 (1) :3637, 2019 10.1038/s41467-019-10968-6

PAK inhibition by PF-3758309 enhanced the sensitivity of multiple chemotherapeutic reagents in patient-derived pancreatic cancer cell lines

Wang, K.; Huynh, N.; Wang, X.; Pajic, M.; Parkin, A.; Man, J.; Baldwin, G. S.; Nikfarjam, M.; He, H.

American Journal of Translational Research 11 (6) :3353-3364, 2019

ATRX loss is an independent predictor of poor survival in pancreatic neuroendocrine tumours

Chou, A.; Itchins, M.; de Reuver, P.R.; Arena, J.; Clarkson, A.; Sheen, A.; Sioson, L.; Cheung, V.; Perren, A.; Nahm, C.; Mittal, A.; Samra, J. S.; Pajic, M.; Gill, A. J.

HUMAN PATHOLOGY 82 :249-257, 2018 10.1016/j.humpath.2018.07.032

Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer

Chou, A.; Froio, D.; Nagrial, A. M.; Parkin, A.; Murphy, K. J.; Chin, V. T.; Wohl, D.; Steinmann, A.; Stark, R.; Drury, A.; Walters, S. N.; Vennin, C.; Burgess, A.; Pinese, M.; Chantrill, L. A.; Cowley, M. J.; Molloy, T. J.; Waddell, N.; Johns, A.; Grimmond, S. M.; Chang, D. K.; Biankin, A. V.; Sansom, O. J.; Morton, J. P.; Grey, S. T.; Cox, T. R.; Turchini, J.; Samra, J.; Clarke, S. J.; Timpson, P.; Gill, A. J.; Pajic, M.

GUT 67 (12) :2142-2155, 2018 10.1136/gutjnl-2017-315144

The Evolving Understanding of the Molecular and Therapeutic Landscape of Pancreatic Ductal Adenocarcinoma

Parkin, A.; Man, J.; Chou, A.; Nagrial, A. M.; Samra, J.; Gill, A. J.; Timpson, P.; Pajic, M.

Diseases 6 (4) :103, 2018 10.3390/diseases6040103

Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors

Hoque, M.; Abbassi, R. H.; Froio, D.; Man, J.; Johns, T. G.; Stringer, B. W.; Day, B. W.; Pajic, M.; Kassiou, M.; Munoz, L.

PHARMACOLOGICAL RESEARCH 134 :166-178, 2018 10.1016/j.phrs.2018.06.023