Publications

66 items matching your search terms.

Oral Squamous Cell Carcinoma in Young Patients Show Higher Rates of EGFR Amplification: Implications for Novel Personalized Therapy

Satgunaseelan, L.; Porazinski, S.; Strbenac, D.; Istadi, A.; Willet, C.; Chew, T.; Sadsad, R.; Palme, C. E.; Lee, J. H.; Boyer, M.; Yang, J. Y. H.; Clark, J. R.; Pajic, M.; Gupta, R.

Frontiers in Oncology 11 :750852, 2021 10.3389/fonc.2021.750852

TLR2 activation promotes tumour growth and associates with patient survival and chemotherapy response in pancreatic ductal adenocarcinoma

Lundy, J.; Gearing, L. J.; Gao, H.; West, A. C.; McLeod, L.; Deswaerte, V.; Yu, L.; Porazinski, S.; Pajic, M.; Hertzog, P. J.; Croagh, D.; Jenkins, B. J.

ONCOGENE 2021 10.1038/s41388-021-01992-2

Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status

Murphy, K. J.; Reed, D. A.; Vennin, C.; Conway, J. R. W.; Nobis, M.; Yin, J. X.; Chambers, C. R.; Pereira, B. A.; Lee, V.; Filipe, E. C.; Trpceski, M.; Ritchie, S.; Lucas, M. C.; Warren, S. C.; Skhinas, J. N.; Magenau, A.; Metcalf, X. L.; Stoehr, J.; Major, G.; Parkin, A.; Bidanel, R.; Lyons, R. J.; Zaratzian, A.; Tayao, M.; Da Silva, A.; Abdulkhalek, L.; Australian Pancreatic Genome, Initiative; Australian Pancreatic Cancer Matrix, Atlas; Gill, A. J.; Johns, A. L.; Biankin, A. V.; Samra, J.; Grimmond, S. M.; Chou, A.; Goetz, J. G.; Samuel, M. S.; Lyons, J. G.; Burgess, A.; Caldon, C. E.; Horvath, L. G.; Daly, R. J.; Gadegaard, N.; Wang, Y.; Sansom, O. J.; Morton, J. P.; Cox, T. R.; Pajic, M.; Herrmann, D.; Timpson, P.

Science Advances 7 (40) :eabh0363, 2021 10.1126/sciadv.abh0363

Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition

Sharbeen, G.; McCarroll, J. A.; Akerman, A.; Kopecky, C.; Youkhana, J.; Kokkinos, J.; Holst, J.; Boyer, C.; Erkan, M.; Goldstein, D.; Timpson, P.; Cox, T. R.; Pereira, B. A.; Chitty, J. L.; Fey, S. K.; Najumudeen, A. K.; Campbell, A. D.; Sansom, O. J.; Ignacio, R. M. C.; Naim, S.; Liu, J.; Russia, N.; Lee, J.; Chou, A.; Johns, A.; Gill, A. J.; Gonzales-Aloy, E.; Gebski, V.; Guan, Y. F.; Pajic, M.; Turner, N.; Apte, M. V.; Davis, T. P.; Morton, J. P.; Haghighi, K. S.; Kasparian, J.; McLean, B. J.; Setargew, Y. F.; Phillips, P. A.; Australian Pancreatic Cancer Genome, Initiative

CANCER RESEARCH 81 (13) :3461-3479, 2021 10.1158/0008-5472.CAN-20-2496

Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1

Kryza, T.; Khan, T.; Lovell, S.; Harrington, B. S.; Yin, J.; Porazinski, S.; Pajic, M.; Koistinen, H.; Rantala, J. K.; Dreyer, T.; Magdolen, V.; Reuning, U.; He, Y.; Tate, E. W.; Hooper, J. D.

Nature Chemical Biology 17 (7) :776-783, 2021 10.1038/s41589-021-00783-w

Breaking the cycle: Targeting of NDRG1 to inhibit bi-directional oncogenic cross-talk between pancreatic cancer and stroma

Geleta, B.; Park, K. C.; Jansson, P. J.; Sahni, S.; Maleki, S.; Xu, Z.; Murakami, T.; Pajic, M.; Apte, M. V.; Richardson, D. R.; Kovacevic, Z.

FASEB JOURNAL 35 (2) :e21347, 2021 10.1096/fj.202002279R

Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

Dreyer, S. B.; Upstill-Goddard, R.; Paulus-Hock, V.; Paris, C.; Lampraki, E. M.; Dray, E.; Serrels, B.; Caligiuri, G.; Rebus, S.; Plenker, D.; Galluzzo, Z.; Brunton, H.; Cunningham, R.; Tesson, M.; Nourse, C.; Bailey, U. M.; Jones, M.; Moran-Jones, K.; Wright, D. W.; Duthie, F.; Oien, K.; Evers, L.; McKay, C. J.; McGregor, G. A.; Gulati, A.; Brough, R.; Bajrami, I.; Pettitt, S.; Dziubinski, M. L.; Candido, J.; Balkwill, F.; Barry, S. T.; Grutzmann, R.; Rahib, L.; Glasgow Precision Oncology, Laboratory; Australian Pancreatic Cancer Genome, Initiative; Johns, A.; Pajic, M.; Froeling, F. E. M.; Beer, P.; Musgrove, E. A.; Petersen, G. M.; Ashworth, A.; Frame, M. C.; Crawford, H. C.; Simeone, D. M.; Lord, C.; Mukhopadhyay, D.; Pilarsky, C.; Tuveson, D. A.; Cooke, S. L.; Jamieson, N. B.; Morton, J. P.; Sansom, O. J.; Bailey, P. J.; Biankin, A. V.; Chang, D. K.

GASTROENTEROLOGY 160 (1) :362-377 e13, 2021 10.1053/j.gastro.2020.09.043

Fats and Mets, KRAS-Driven Lipid Dysregulation Affects Metastatic Potential in Pancreatic Cancer

Man, J.; Pajic, M.; Joshua, A. M.

CANCER RESEARCH 80 (22) :4886-4887, 2020 10.1158/0008-5472.CAN-20-3082

Precision oncology in surgery: Patient selection for operable pancreatic cancer

Dreyer, S. B.; Pinese, M.; Jamieson, N. B.; Scarlett, C. J.; Colvin, E. K.; Pajic, M.; Johns, A. L.; Humphris, J. L.; Wu, J.; Cowley, M. J.; Chou, A.; Nagrial, A. M.; Chantrill, L.; Chin, V. T.; Jones, M. D.; Moran-Jones, K.; Carter, C. R.; Dickson, E. J.; Samra, J. S.; Merrett, N. D.; Gill, A. J.; Kench, J. G.; Duthie, F.; Miller, D. K.; Cooke, S.; Aust, D.; Knosel, T.; Rummele, P.; Grutzmann, R.; Pilarsky, C.; Nguyen, N. Q.; Musgrove, E. A.; Bailey, P. J.; McKay, C. J.; Biankin, A. V.; Chang, D. K.; Australian Pancreatic Cancer Genome, Initiative; Glasgow Precision Oncology, Laboratory

ANNALS OF SURGERY 272 (2) :366-376, 2020 10.1097/SLA.0000000000003143

MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer

Cipponi, A.; Goode, D. L.; Bedo, J.; McCabe, M. J.; Pajic, M.; Croucher, D. R.; Rajal, A. G.; Junankar, S. R.; Saunders, D. N.; Lobachevsky, P.; Papenfuss, A. T.; Nessem, D.; Nobis, M.; Warren, S. C.; Timpson, P.; Cowley, M.; Vargas, A. C.; Qiu, M. R.; Generali, D. G.; Keerthikumar, S.; Nguyen, U.; Corcoran, N. M.; Long, G. V.; Blay, J. Y.; Thomas, D. M.

SCIENCE 368 (6495) :1127-1131, 2020 10.1126/science.aau8768

HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer

Brunton, H.; Caligiuri, G.; Cunningham, R.; Upstill-Goddard, R.; Bailey, U. M.; Garner, I. M.; Nourse, C.; Dreyer, S.; Jones, M.; Moran-Jones, K.; Wright, D. W.; Paulus-Hock, V.; Nixon, C.; Thomson, G.; Jamieson, N. B.; McGregor, G. A.; Evers, L.; McKay, C. J.; Gulati, A.; Brough, R.; Bajrami, I.; Pettitt, S. J.; Dziubinski, M. L.; Barry, S. T.; Grutzmann, R.; Brown, R.; Curry, E.; Glasgow Precision Oncology, Laboratory; Australian Pancreatic Cancer Genome, Initiative; Pajic, M.; Musgrove, E. A.; Petersen, G. M.; Shanks, E.; Ashworth, A.; Crawford, H. C.; Simeone, D. M.; Froeling, F. E. M.; Lord, C. J.; Mukhopadhyay, D.; Pilarsky, C.; Grimmond, S. E.; Morton, J. P.; Sansom, O. J.; Chang, D. K.; Bailey, P. J.; Biankin, A. V.

Cell Reports 31 (6) :107625, 2020 10.1016/j.celrep.2020.107625

RET gene rearrangements occur in a subset of pancreatic acinar cell carcinomas

Chou, A.; Brown, I. S.; Kumarasinghe, M. P.; Perren, A.; Riley, D.; Kim, Y.; Pajic, M.; Steinmann, A.; Rathi, V.; Jamieson, N. B.; Verheij, J.; van Roessel, S.; Nahm, C. B.; Mittal, A.; Samra, J.; Gill, A. J.

MODERN PATHOLOGY 33 (4) :657-664, 2020 10.1038/s41379-019-0373-y

Effective targeting of intact and proteolysed CDCP1 for imaging and treatment of pancreatic ductal adenocarcinoma

Kryza, T.; Khan, T.; Puttick, S.; Li, C.; Sokolowski, K. A.; Tse, B. W.; Cuda, T.; Lyons, N.; Gough, M.; Yin, J.; Parkin, A.; Deryugina, E. I.; Quigley, J. P.; Law, R. H. P.; Whisstock, J. C.; Riddell, A. D.; Barbour, A. P.; Wyld, D. K.; Thomas, P. A.; Rose, S.; Snell, C. E.; Pajic, M.; He, Y.; Hooper, J. D.

Theranostics 10 (9) :4116-4133, 2020 10.7150/thno.43589

Systematic functional identification of cancer multi-drug resistance genes

Lau MT., Ghazanfar S., Parkin A., Chou A., Rouaen JR., Littleboy JB., Nessem D., Khuong TM., Nevoltris D., Schofield P., Langley D., Christ D., Yang J., Pajic M., Neely GG.

GENOME BIOLOGY 21 (1) :27, 2020 https://doi.org/10.1186/s13059-020-1940-8

MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma

Castillo, L.; Young, A. I. J.; Mawson, A.; Schafranek, P.; Steinmann, A. M.; Nessem, D.; Parkin, A.; Johns, A.; Chou, A.; Law, A. M. K.; Lucas, M. C.; Murphy, K. J.; Deng, N.; Gallego-Ortega, D.; Caldon, C. E.; Australian Pancreatic Cancer Genome, Initiative; Timpson, P.; Pajic, M.; Ormandy, C. J.; Oakes, S. R.

ONCOGENE 39 (8) :1821-1829, 2020 10.1038/s41388-019-1091-0

Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy

Vennin, C.; Rath, N.; Pajic, M.; Olson, M. F.; Timpson, P.

Small GTPases 11 (1) :45-52, 2020 10.1080/21541248.2017.1345712