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44 items matching your search terms.
Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer
Wong, M.; Mayoh, C.; Lau, L. M. S.; Khuong-Quang, D. A.; Pinese, M.; Kumar, A.; Barahona, P.; Wilkie, E. E.; Sullivan, P.; Bowen-James, R.; Syed, M.; Martincorena, I.; Abascal, F.; Sherstyuk, A.; Bolanos, N. A.; Baber, J.; Priestley, P.; Dolman, M. E. M.; Fleuren, E. D. G.; Gauthier, M. E.; Mould, E. V. A.; Gayevskiy, V.; Gifford, A. J.; Grebert-Wade, D.; Strong, P. A.; Manouvrier, E.; Warby, M.; Thomas, D. M.; Kirk, J.; Tucker, K.; O'Brien, T.; Alvaro, F.; McCowage, G. B.; Dalla-Pozza, L.; Gottardo, N. G.; Tapp, H.; Wood, P.; Khaw, S. L.; Hansford, J. R.; Moore, A. S.; Norris, M. D.; Trahair, T. N.; Lock, R. B.; Tyrrell, V.; Haber, M.; Marshall, G. M.; Ziegler, D. S.; Ekert, P. G.; Cowley, M. J.
NATURE MEDICINE 26 (11) :1742-1753, 2020 10.1038/s41591-020-1072-4
Precision oncology in surgery: Patient selection for operable pancreatic cancer
Dreyer, S. B.; Pinese, M.; Jamieson, N. B.; Scarlett, C. J.; Colvin, E. K.; Pajic, M.; Johns, A. L.; Humphris, J. L.; Wu, J.; Cowley, M. J.; Chou, A.; Nagrial, A. M.; Chantrill, L.; Chin, V. T.; Jones, M. D.; Moran-Jones, K.; Carter, C. R.; Dickson, E. J.; Samra, J. S.; Merrett, N. D.; Gill, A. J.; Kench, J. G.; Duthie, F.; Miller, D. K.; Cooke, S.; Aust, D.; Knosel, T.; Rummele, P.; Grutzmann, R.; Pilarsky, C.; Nguyen, N. Q.; Musgrove, E. A.; Bailey, P. J.; McKay, C. J.; Biankin, A. V.; Chang, D. K.; Australian Pancreatic Cancer Genome, Initiative; Glasgow Precision Oncology, Laboratory
ANNALS OF SURGERY 272 (2) :366-376, 2020 10.1097/SLA.0000000000003143
OpenAccess publication The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly
Pinese, M.; Lacaze, P.; Rath, E.M.; Stone, A.; Brion, M.J.; Ameur, A.; Nagpal, S.; Puttick, C.; Husson, S.; Degrave, D.; Cristina, T.N.; Kahl, V.F.S.; Statham, A.L.; Woods, R.L.; McNeil, J.J.; Riaz, M.; Barr, M.; Nelson, M.R.; Reid, C.M.; Murray, A.M.; Shah, R.C.; Wolfe, R.; Atkins, J.R.; Fitzsimmons, C.; Cairns, H.M.; Green, M.J.; Carr, V.J.; Cowley, M.J.; Pickett, H.A.; James, P.A.; Powell, J.E.; Kaplan, W.; Gibson, G.; Gyllensten, U.; Cairns, M.J.; McNamara, M.; Dinger, M. E.; Thomas, D.M.
Nature Communications 11 (1) :435, 2020 10.1038/s41467-019-14079-0
CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan
Vennin, C.; Melenec, P.; Rouet, R.; Nobis, M.; Cazet, A. S.; Murphy, K. J.; Herrmann, D.; Reed, D. A.; Lucas, M. C.; Warren, S. C.; Elgundi, Z.; Pinese, M.; Kalna, G.; Roden, D.; Samuel, M.; Zaratzian, A.; Grey, S. T.; Da Silva, A.; Leung, W.; Mathivanan, S.; Wang, Y.; Braithwaite, A. W.; Christ, D.; Benda, A.; Parkin, A.; Phillips, P. A.; Whitelock, J. M.; Gill, A. J.; Sansom, O. J.; Croucher, D. R.; Parker, B. L.; Pajic, M.; Morton, J. P.; Cox, T. R.; Timpson, P.
Nature Communications 10 (1) :3637, 2019 10.1038/s41467-019-10968-6
Therapeutic implications of germline genetic findings in cancer
Thavaneswaran, S.; Rath, E.; Tucker, K.; Joshua, A. M.; Hess, D.; Pinese, M.; Ballinger, M. L.; Thomas, D. M.
Nature Reviews Clinical Oncology 16 (6) :386-396, 2019 10.1038/s41571-019-0179-3
OpenAccess publication Identification of novel sarcoma risk genes using a two-stage genome wide DNA sequencing strategy in cancer cluster families and population case and control cohorts
Jones, R. M.; Melton, P. E.; Pinese, M.; Rea, A. J.; Ingley, E.; Ballinger, M. L.; Wood, D. J.; Thomas, D. M.; Moses, E. K.
BMC Medical Genetics 20 (1) :69, 2019 10.1186/s12881-019-0808-9
Genomic stratification and liquid biopsy in a rare adrenocortical carcinoma (ACC) case, with dual lung metastases
McCabe, M. J.; Pinese, M.; Chan, C. L.; Sheriff, N.; Thompson, T. J.; Grady, J.; Wong, M.; Gauthier, M. A.; Puttick, C.; Gayevskiy, V.; Hajdu, E.; Wong, S. Q.; Barrett, W.; Earls, P.; Lukeis, R.; Cheng, Y. Y.; Lin, R. C. Y.; Thomas, D. M.; Watkins, D. N.; Dinger, M. E.; McCormack, A. I.; Cowley, M. J.
Cold Spring Harbor molecular case studies 5 (2) :pii: a003764, 2019 10.1101/mcs.a003764
The Medical Genome Reference Bank: a whole-genome data resource of 4000 healthy elderly individuals. Rationale and cohort design
Lacaze, P.; Pinese, M.; Kaplan, W.; Stone, A.; Brion, M. J.; Woods, R. L.; McNamara, M.; McNeil, J. J.; Dinger, M. E.; Thomas, D. M.
EUROPEAN JOURNAL OF HUMAN GENETICS 27 (2) :308-316, 2019 10.1038/s41431-018-0279-z
Translating genomic risk into an early detection strategy for sarcoma
Ballinger, M. L.; Pinese, M.; Thomas, D. M.
GENES CHROMOSOMES & CANCER 58 :130-136, 2019 10.1002/gcc.22697
Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer
Chou, A.; Froio, D.; Nagrial, A. M.; Parkin, A.; Murphy, K. J.; Chin, V. T.; Wohl, D.; Steinmann, A.; Stark, R.; Drury, A.; Walters, S. N.; Vennin, C.; Burgess, A.; Pinese, M.; Chantrill, L. A.; Cowley, M. J.; Molloy, T. J.; Waddell, N.; Johns, A.; Grimmond, S. M.; Chang, D. K.; Biankin, A. V.; Sansom, O. J.; Morton, J. P.; Grey, S. T.; Cox, T. R.; Turchini, J.; Samra, J.; Clarke, S. J.; Timpson, P.; Gill, A. J.; Pajic, M.
GUT 67 (12) :2142-2155, 2018 10.1136/gutjnl-2017-315144
Integration of genomics, high throughput drug screening, and personalized xenograft models as a novel precision medicine paradigm for high risk pediatric cancer
Tsoli, M.; Wadham, C.; Pinese, M.; Failes, T.; Joshi, S.; Mould, E.; Yin, J. X.; Gayevskiy, V.; Kumar, A.; Kaplan, W.; Ekert, P. G.; Saletta, F.; Franshaw, L.; Liu, J.; Gifford, A.; Weber, M. A.; Rodriguez, M.; Cohn, R. J.; Arndt, G.; Tyrrell, V.; Haber, M.; Trahair, T.; Marshall, G. M.; McDonald, K.; Cowley, M. J.; Ziegler, D. S.
CANCER BIOLOGY & THERAPY 19 :1078-1087, 2018 10.1080/15384047.2018.1491498
Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma
Ziegler, D. S.; Wong, M.; Mayoh, C.; Kumar, A.; Tsoli, M.; Mould, E.; Tyrrell, V.; Khuong-Quang, D. A.; Pinese, M.; Gayevskiy, V.; Cohn, R. J.; Lau, L. M. S.; Reynolds, M.; Cox, M. C.; Gifford, A.; Rodriguez, M.; Cowley, M. J.; Ekert, P. G.; Marshall, G. M.; Haber, M.
British Journal of Cancer 2018 10.1038/s41416-018-0251-2
OpenAccess publication BAMLET kills chemotherapy-resistant mesothelioma cells, holding oleic acid in an activated cytotoxic state
Rath, E. M.; Cheng, Y. Y.; Pinese, M.; Sarun, K. H.; Hudson, A. L.; Weir, C.; Wang, Y. D.; Hakansson, A. P.; Howell, V. M.; Liu, G. J.; Reid, G.; Knott, R. B.; Duff, A. P.; Church, W. B.
PLoS One 13 (8) :e0203003, 2018 10.1371/journal.pone.0203003
OpenAccess publication Intravital imaging to monitor therapeutic response in moving hypoxic regions resistant to PI3K pathway targeting in pancreatic cancer
Conway, J. R. W.; Warren, S. C.; Herrmann, D.; Murphy, K. J.; Cazet, A. S.; Vennin, C.; Shearer, R. F.; Killen, M. J.; Magenau, A.; Melenec, P.; Pinese, M.; Nobis, M.; Zaratzian, A.; Boulghourjian, A.; Da Silva, A. M.; Del Monte-Nieto, G.; Adam, A. S. A.; Harvey, R. P.; Haigh, J. J.; Wang, Y.; Croucher, D. R.; Sansom, O. J.; Pajic, M.; Caldon, C. E.; Morton, J. P.; Timpson, P.
Cell Reports 23 (11) :3312-3326, 2018 10.1016/j.celrep.2018.05.038
OpenAccess publication Adar3 Is Involved in Learning and Memory in Mice
Mladenova, D.; Barry, G.; Konen, L. M.; Pineda, S. S.; Guennewig, B.; Avesson, L.; Zinn, R.; Schonrock, N.; Bitar, M.; Jonkhout, N.; Crumlish, L.; Kaczorowski, D. C.; Gong, A.; Pinese, M.; Franco, G. R.; Walkley, C. R.; Vissel, B.; Mattick, J. S.
Frontiers in Neuroscience 12 (243) :1-17, 2018 10.3389/fnins.2018.00243