Publications

16 items matching your search terms.

Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages

Munoz, M. A.; Fletcher, E. K.; Skinner, O. P.; Jurczyluk, J.; Kristianto, E.; Hodson, M. P.; Sun, S.; Ebetino, F. H.; Croucher, D. R.; Hansbro, P. M.; Center, J. R.; Rogers, M. J.

eLife 10 :e72430, 2021 10.7554/eLife.72430

Oxysterols: From physiological tuners to pharmacological opportunities

Brown, A. J.; Sharpe, L. J.; Rogers, M. J.

BRITISH JOURNAL OF PHARMACOLOGY 178 (16) :3089-3103, 2021 10.1111/bph.15073

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

McDonald, M. M.; Khoo, W. H.; Ng, P. Y.; Xiao, Y.; Zamerli, J.; Thatcher, P.; Kyaw, W.; Pathmanandavel, K.; Grootveld, A. K.; Moran, I.; Butt, D.; Nguyen, A.; Corr, A.; Warren, S.; Biro, M.; Butterfield, N. C.; Guilfoyle, S. E.; Komla-Ebri, D.; Dack, M. R. G.; Dewhurst, H. F.; Logan, J. G.; Li, Y.; Mohanty, S. T.; Byrne, N.; Terry, R. L.; Simic, M. K.; Chai, R.; Quinn, J. M. W.; Youlten, S. E.; Pettitt, J. A.; Abi-Hanna, D.; Jain, R.; Weninger, W.; Lundberg, M.; Sun, S.; Ebetino, F. H.; Timpson, P.; Lee, W. M.; Baldock, P. A.; Rogers, M. J.; Brink, R.; Williams, G. R.; Bassett, J. H. D.; Kemp, J. P.; Pavlos, N. J.; Croucher, P. I.; Phan, T. G.

CELL 184 (5) :1330-1347 e13, 2021 10.1016/j.cell.2021.02.002

Synthesis and Characterization of Bone Binding Antibiotic-1 (BBA-1), a Novel Antimicrobial for Orthopedic Applications

Kamble, S.; Valtchev, P.; Dao, A.; Pelras, T.; Rogers, M. J.; Savage, P. B.; Dehghani, F.; Schindeler, A.

MOLECULES 26 (6) 2021 10.3390/molecules26061541

Molecular mechanisms of action of bisphosphonates and new insights into their effects outside the skeleton

Rogers, M. J.; Monkkonen, J.; Munoz, M. A.

BONE 139 :115493, 2020 10.1016/j.bone.2020.115493

Oxysterols: From Physiological Tuners to Pharmacological Opportunities

Brown, A. J.; Sharpe, L. J.; Rogers, M. J.

BRITISH JOURNAL OF PHARMACOLOGY 2020 10.1111/bph.15073

Defective Protein Prenylation in a Spectrum of Patients With Mevalonate Kinase Deficiency

Munoz, M. A.; Jurczyluk, J.; Simon, A.; Hissaria, P.; Arts, R. J. W.; Coman, D.; Boros, C.; Mehr, S.; Rogers, M. J.

Frontiers in Immunology 10 :1900, 2019 10.3389/fimmu.2019.01900

Lack of protein prenylation promotes NLRP3 inflammasome assembly in human monocytes

Skinner, O. P.; Jurczyluk, J.; Baker, P. J.; Masters, S. L.; Rios Wilks, A. G.; Clearwater, M. S.; Robertson, A. A. B.; Schroder, K.; Mehr, S.; Munoz, M. A.; Rogers, M. J.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 143 (6) :2315-2317 e3, 2019 10.1016/j.jaci.2019.02.013

From vesicle to cytosol

Rogers, M. J.; Munoz, M. A.

eLife 7 :e38847, 2018 10.7554/eLife.38847

Osteoglycin, a novel coordinator of bone and glucose homeostasis

Lee, N. J.; Ali, N.; Zhang, L.; Qi, Y.; Clarke, I.; Enriquez, R. F.; Brzozowska, M.; Lee, I. C.; Rogers, M. J.; Laybutt, D. R.; Center, J. R.; Baldock, P. A.; Herzog, H.

Molecular Metabolism 13 (July 18) :30-44, 2018 10.1016/j.molmet.2018.05.004

Defective protein prenylation is a diagnostic biomarker of mevalonate kinase deficiency

Munoz, M. A.; Jurczyluk, J.; Mehr, S.; Chai, R. C.; Arts, R. J. W.; Sheu, A.; McMahon, C.; Center, J. R.; Singh-Grewal, D.; Chaitow, J.; Campbell, D. E.; Quinn, J. M. W.; Alexandrov, K.; Tnimov, Z.; Tangye, S. G.; Simon, A.; Phan, T. G.; Rogers, M. J.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 140 (3) :873-875.e6, 2017 10.1016/j.jaci.2017.02.033

Bone turnover markers and prostate cancer: Not just a measure of bone disease?

Croucher, P. I. ; Parker, B. S. ; Corcoran, N. ; Rogers, M. J.;

EUROPEAN UROLOGY 68 (1) :51-2, 2015

Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche

Lawson, M.A.; McDonald, M.M.; Kovacic, N.; Khoo, W.H.; Terry, R.L.; Down, J.; Kaplan, K.; Paton-Hough, J.; Fellows, C.; Pettitt, J.A.; Dear, T.N.; Van Valckenborgh, E.; Baldock, P.A.; Rogers, M.J.; Eaton, C.L.; Vanderkerken, K.; Pettit, A.R.; Quinn, J.M.W.; Zannettino, A.C.W.; Phan, T.G.; Croucher, P.I

Nature Communications 6 :8983, 2015

A highly sensitive prenylation assay reveals in vivo effects of bisphosphonate drug on the Rab prenylome of macrophages outside the skeleton

Ali, N. ; Jurczyluk, J. ; Shay, G. ; Tnimov, Z. ; Alexandrov, K. ; Munoz, M. A. ; Skinner, O. P. ; Pavlos, N. J. ; Rogers, M. J.;

Small GTPases 30 (4) :637-46, 2015

Real-time intravital imaging establishes tumor-associated macrophages as the extraskeletal target of bisphosphonate action in cancer

Junankar, S.; Shay, G.; Jurczyluk, J.; Ali, N.; Down, J.; Pocock, N.; Parker, A.; Nguyen, A.; Sun, S.; Kashemirov, B.; Mckenna, C.E.; Croucher, P.I.; Swarbrick, A.; Weilbaecher, K.; Phan, T.G.; Rogers, M.J.

Cancer Discovery 5 :35-42, 2015

Upregulation of endogenous farnesyl diphosphate synthase overcomes the inhibitory effect of bisphosphonate on protein prenylation in Hela cells.

Das, S.; Edwards, P.A.; Crockett, J.C.; Rogers, M.J.

BBA-MOL BASIS DIS 1841 (4) :569-73, 2014