Garvan Institute of Medical Research

Genomic diagnostics in polycystic kidney disease: an assessment of real-world use of whole-genome sequencing

Mallawaarachchi, A. C.; Lundie, B.; Hort, Y.; Schonrock, N.; Senum, S. R.; Gayevskiy, V.; Minoche, A. E.; Hollway, G.; Ohnesorg, T.; Hinchcliffe, M.; Patel, C.; Tchan, M.; Mallett, A.; Dinger, M. E.; Rangan, G.; Cowley, M. J.; Harris, P. C.; Burnett, L.; Shine, J.; Furlong, T. J.

EUROPEAN JOURNAL OF HUMAN GENETICS 29 (5) :760-770, 2021 10.1038/s41431-020-00796-4

Population data improves variant interpretation in autosomal dominant polycystic kidney disease

Mallawaarachchi, A. C.; Furlong, T. J.; Shine, J.; Harris, P. C.; Cowley, M. J.

GENETICS IN MEDICINE 21 (6) :1425-1434, 2019 10.1038/s41436-018-0324-x

Role of neuropeptide Y (NPY) in the differentiation of Trpm-5-positive olfactory microvillar cells

Doyle, K. L.; Cunha, C.; Hort, Y.; Tasan, R.; Sperk, G.; Shine, J.; Herzog, H.

NEUROPEPTIDES 68 (April 18) :90-98, 2018 10.1016/j.npep.2018.02.007

Whole-genome sequencing overcomes pseudogene homology to diagnose autosomal dominant polycystic kidney disease

Mallawaarachchi, A. C. ; Hort, Y. ; Cowley, M. J. ; McCabe, M. J. ; Minoche, A. ; Dinger, M. E. ; Shine, J. ; Furlong, T. J.;

EUROPEAN JOURNAL OF HUMAN GENETICS 24 (11) :1584-1590, 2016

Morphological and behavioural changes occur following the X-ray irradiation of the adult mouse olfactory neuroepithelium

Cunha, C.; Hort, Y.; Shine, J.; Doyle, K. L.;

BMC NEUROSCIENCE 13 (1) :134, 2012

Galanin negatively modulates opiate withdrawal via galanin receptor 1

Holmes, F. E.; Armenaki, A.; Iismaa, T. P.; Einstein, E. B.; Shine, J.; Picciotto, M. R.; Wynick, D.; Zachariou, V.;

PSYCHOPHARMACOLOGY 220 (3) :619-25, 2012

Neuropeptide Y and peptide YY have distinct roles in adult mouse olfactory neurogenesis

Doyle, K. L.; Hort, Y. J.; Herzog, H.; Shine, J.;

JOURNAL OF NEUROSCIENCE RESEARCH 90 (6) :1126-35, 2012

Y1 receptors are critical for the proliferation of adult mouse precursor cells in the olfactory neuroepithelium

Doyle, K. L.;Karl, T.;Hort, Y.;Duffy, L.;Shine, J.;Herzog, H. :

JOURNAL OF NEUROCHEMISTRY 105 (3) :641-52, 2008

Galanin receptor-1 knockout mice exhibit spontaneous epilepsy, abnormal EEGs and altered inhibition in the hippocampus

McColl, C. D.; Jacoby, A. S.; Shine, J.; Iismaa, T. P.; Bekkers, J. M.

NEUROPHARMACOLOGY 50 (2) :209-18, 2006

Learning and memory performance in mice lacking the GAL-R1 subtype of galanin receptor

Wrenn, C. C.; Kinney, J. W.; Marriott, L. K.; Holmes, A.; Harris, A. P.; Saavedra, M. C.; Starosta, G.; Innerfield, C. E.; Jacoby, A. S.; Shine, J.; Iismaa, T. P.; Wenk, G. L.; Crawley, J. N.

EUROPEAN JOURNAL OF NEUROSCIENCE 19 (5) :1384-96, 2004

The second galanin receptor GalR2 plays a key role in neurite outgrowth from adult sensory neurons

Mahoney, S. A.;Hosking, R.;Farrant, S.;Holmes, F. E.;Jacoby, A. S.;Shine, J.;Iismaa, T. P.;Scott, M. K.;Schmidt, R.;Wynick, D. :

JOURNAL OF NEUROSCIENCE 23 (2) :416-21, 2003

Galanin GAL-R1 receptor null mutant mice display increased anxiety-like behavior specific to the elevated plus-maze

Holmes, A.;Kinney, J. W.;Wrenn, C. C.;Li, Q.;Yang, R. J.;Ma, L.;Vishwanath, J.;Saavedra, M. C.;Innerfield, C. E.;Jacoby, A. S.;Shine, J.;Iismaa, T. P.;Crawley, J. N. :

BIOLOGICAL PSYCHIATRY 28 (6) :1031-44, 2003

Hyperalgesia and increased neuropathic pain-like response in mice lacking galanin receptor 1 receptors

Blakeman, K. H.;Hao, J. X.;Xu, X. J.;Jacoby, A. S.;Shine, J.;Crawley, J. N.;Iismaa, T.;Wiesenfeld-Hallin, Z. :

NEUROSCIENCE 117 (1) :221-7, 2003

Altered hippocampal expression of neuropeptides in seizure-prone GALR1 knockout mice

Fetissov, S. O.;Jacoby, A. S.;Brumovsky, P. R.;Shine, J.;Iismaa, T. P.;Hokfelt, T. :

EPILEPSIA 44 (8) :1022-33, 2003

Molecular modelling and site-directed mutagenesis of human GALR1 galanin receptor defines determinants of receptor subtype specificity

Church, W. B.;Jones, K. A.;Kuiper, D. A.;Shine, J.;Iismaa, T. P. :

Protein Eng 15 (4) :313-23, 2002

Phenotypic analysis of Galr1 knockout mice reveals a role for GALR1 galanin receptor in modulating seizure activity but not nerve regeneration

Jacoby, A. S.;Holmes, F. E.;Hort, Y. J.;Shine, J.;Iismaa, T. P. :